Please download the dossier by clicking on the dossier button x
×

Iron catalyzed cross-coupling reactions of imidoyl derivatives

  • US 20070106074A1
  • Filed: 10/17/2006
  • Published: 05/10/2007
  • Est. Priority Date: 10/17/2005
  • Status: Abandoned Application
First Claim
Patent Images

1. A process for preparing a compound of formula A-N═

  • C(D)(B), from a compound of formula A-N═

    C(E)(B) and a compound of formula D-M using an iron catalyst, where the process is represented by Equation (I) embedded image Wherein;

    A and B are independently selected from the group consisting of optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heteroalicyclyl, —

    C(=Z)R1, —

    C(=Z)OR1, —

    C(=Z)NR1aR1b, —

    C(R1)═

    NR1a, —

    NR1aR1b, —

    N═

    CR1aR1b, —

    N(R1)—

    C(=Z)R1, —

    N(R1)—

    C(=Z)NR1aR1b, —

    S(O)NR1aR1b, —

    S(O)2NR1aR1b, —

    N(R1)—

    S(═

    O)R1, —

    N(R1)—

    S(═

    O)2R1, —

    OR1, —

    SR1, and —

    OC(=Z)R1, or A and B taken together, along with the nitrogen atom to which A is attached and the carbon atom to which B is attached, form a ring;

    E is selected from the group consisting of halide, sulfonate (—

    OSO3R2), and phosphonate (—

    OP(O)(OR2a)(OR2b));

    D is selected from group consisting of optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted aryl, optionally substituted heteroaryl, and optionally substituted heteroalicyclyl;

    M is selected from the group consisting of MgY, CaY, ZnY, MnY, and Mg derived metal reagents formed from reaction of MgY and other metal salts, such as Cu(CN)MgCl and Mn(Cl2)MgCl;

    Y is an anionic ligand R1, R1a and R1b are independently selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heteroalicyclyl;

    R2, R2a and R2b are independently selected from the group consisting of haloalkyl, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heteroalicyclyl; and

    Z is O (oxygen) or S (sulfur).

View all claims
  • 1 Assignment
Timeline View
Assignment View
    ×
    ×