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RETROGRADE PRESSURE REGULATED INFUSION

  • US 20070106258A1
  • Filed: 12/11/2006
  • Published: 05/10/2007
  • Est. Priority Date: 03/12/2003
  • Status: Active Grant
First Claim
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1. A method comprising:

  • positioning a catheter into a blood vessel; and

    locally administering a therapeutic agent to the blood vessel in a direction opposite blood flow, the therapeutic agent selected from the group consisting of cells, antibodies against CD18, CD11/18, P-selectin, L-selectin, ICAM, VCAM, and TNF, estrogen and estrogen receptor agonists, growth factors, and their isoforms and downstream signaling mediators, heat shock proteins and their downstream signaling mediators, GIK, adenosine and adenosine receptor agonists, NO donors, Na/H exchange inhibitors, Na/K channel openers and their downstream signaling mediators, Ca channel inhibitors, beta-adrenergic receptor inhibitors, alpha-adrenergic receptor inhibitors, free radical scavengers, anti-oxidants, platelet inhibitors, complement system inhibitors, anti-apoptotic drugs, genes that encode peptides or their ligands, bio-engineered cells or materials that express the peptides or glycoproteins or their ligands, and mixtures thereof;

    wherein said agent is administered by the catheter, the catheter comprising;

    a shaft comprising a proximal end and a distal end, and defining a delivery lumen through a portion thereof, the delivery lumen comprising a proximal end and a distal end;

    a delivery port coupled to the distal end of the delivery lumen;

    a pressure monitoring lumen, a portion of the pressure monitoring lumen disposed within the shaft, comprising a proximal end and a distal end;

    a pressure port coupled to the distal end of the pressure monitoring lumen;

    a balloon inflation lumen, a portion of the balloon inflation lumen disposed within the shaft, comprising a proximal end and a distal end;

    a low-pressure high-compliance balloon adjacent to the distal end of the flexible shaft, the balloon comprising at least one material selected from the group consisting of polyether block amide resins, blends of polyether block amide resins, a composite including an elastomeric material and EPTFE, a styrene-isoprene-styrene tri-Block co-polymer, and blends and mixtures thereof;

    wherein, prior to administering, inflating the balloon to at least an elasticity of about 40% at a pre-determined gauge pressure of about 0.5 to about 6.0 atmospheres.

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