Integrated biosensor and simulation system for diagnosis and therapy

• US 20070106333A1
• Filed: 12/22/2006
• Published: 05/10/2007
• Est. Priority Date: 08/22/2003
• Status: Abandoned Application

• Current Assignee: Dennis Fernandez
• Original Assignee: Dennis Fernandez
• Inventors: Fernandez, Dennis
• Application Number:
  US11/644,420
• Publication Number:
  US 20070106333A1
• Time in Patent Office: Days
• US Class Current: 607/2
• CPC Class Codes: A61B 2562/028 Microscale sensors, e.g. electromechanical sensors [MEMS]
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/02028 Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/024 Detecting, measuring or recording pulse rate or heart rate A61B5/0205, A61B5/021 take precedence
• CPC Class Codes: A61B 5/026 Measuring blood flow A61B3/1233, A61B3/1241 take precedence
• CPC Class Codes: A61B 5/076 Permanent implantations telemetry using implanted circuitry A61B5/0031; implanted stimulators for therapy A61N1/3605, A61N1/362, A61N1/372
• CPC Class Codes: A61B 5/145 Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissuemeasuring of blood pressure or blood flow A61B5/02; non-radiation detecting or locating of foreign bodies in blood A61B5/06
• CPC Class Codes: A61B 5/14539 for measuring pH
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/411 Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
• CPC Class Codes: A61B 5/413 Monitoring transplanted tissue or organ, e.g. for possible rejection reactions after a transplant
• CPC Class Codes: A61B 5/415 the glands, e.g. tonsils, adenoids or thymus
• CPC Class Codes: A61B 5/418 lymph vessels, ducts or nodes
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/486 Bio-feedback A61B5/375 takes precedence
• CPC Class Codes: A61B 5/686 Permanently implanted devices, e.g. pacemakers, other stimulators, biochips A61B5/6861 takes precedence
• CPC Class Codes: A61B 5/7264 Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems neural networks per se G06N3/00; expert systems per se G06N5/00
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: C12Q 1/04 : Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor C12Q1/6897 takes precedence
• CPC Class Codes: C12Q 1/68 : involving nucleic acids
• CPC Class Codes: C12Q 1/6886 : for cancer immunoassay for cancer G01N33/574
• CPC Class Codes: C12Q 1/70 : involving virus or bacteriophage immunoassay for viruses G01N33/56983
• CPC Class Codes: C12Q 2600/156 : Polymorphic or mutational markers
• CPC Class Codes: G01N 33/53 : Immunoassay; Biospecific binding assay; Materials therefor
• CPC Class Codes: G06Q 40/08 : Insurance
• CPC Class Codes: G06Q 50/22 : Social work or social welfare, e.g. community support activities or counselling services
• CPC Class Codes: G16B 5/00 : ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
• CPC Class Codes: G16B 5/20 : Probabilistic models
• CPC Class Codes: G16B 5/30 : Dynamic-time models
• CPC Class Codes: G16H 10/60 : for patient-specific data, e.g. for electronic patient records
• CPC Class Codes: G16H 40/63 : for local operation
• CPC Class Codes: G16H 50/50 : for simulation or modelling of medical disorders
• CPC Class Codes: G16H 70/60 : relating to pathologies
• CPC Class Codes: Y02A 90/10 : Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

BioMEMS/NEMS appliance biologically monitors an individual, using biosensors to detect cellular components. Data is simulated or analyzed using systems-biology software, which provides diagnostic or therapeutic guidance.

Claims

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21. Sensor apparatus comprising:

a multi-functional array coupled programmably to a peptide or protein sensor, an antibody sensor, a carbohydrate sensor, and a cell sensor.

22. The apparatus of claim 21 wherein:

the sensor array comprises a reconfigurable hardware switch logically interconnecting a plurality of biosensors to a networked controller.

23. The apparatus of claim 21 further comprising:

a positioning chip, coupled to one or more of the array sensors.

24. The apparatus of claim 23 wherein:

the positioning chip comprises a patch clamp.

25. The apparatus of claim 21 wherein:

the peptide or protein sensor comprises an electrophoresis tag or micro-assay, or protein chip.

26. The apparatus of claim 21 wherein:

the antibody sensor comprises a phagotope biochip.

27. The apparatus of claim 21 wherein:

the sensor array couples further to a vector or virus vector sensor comprising a micro-array or assay with known sequenced virus attached, or a micro-array or assay that detects homologs.

28. The apparatus of claim 21 wherein:

the carbohydrate sensor comprises a glycochip, or a whole blood glucose monitoring system.

29. The apparatus of claim 21 wherein:

the cell sensor comprises a bionic chip for cell-growth.

30. The apparatus of claim 21 further comprising:

a therapeutic unit comprising a pill comprising a micro-pump, a polymer scaffold comprising hydrogel, or an implantable bio-MEMs chip comprising a medication reservoir, such unit being coupled to at least one sensor.

31. The apparatus of claim 21 wherein:

the sensor array couples further to a DNA sensor comprising a micro-array or assay.

32. The apparatus of claim 31 further comprising:

a controller comprising a systems-biology platform that determines automatedly when the DNA sensor detects a genomic mutation indicating compromised ability to produce thiopurine S-methyltransferase enzyme.

33. Sensor apparatus comprising:

a multi-functional array coupled programmably to a peptide or protein sensor, an antibody sensor, a carbohydrate sensor, or a cell sensor;

a positioning chip, coupled to one or more of the array sensors;

a therapeutic unit comprising a pill comprising a micro-pump, a polymer scaffold comprising hydrogel, or an implantable bio-MEMs chip comprising a medication reservoir; and

a controller that controls the therapeutic unit or the sensor array.

34. Sensor apparatus comprising:

a multi-functional array coupled programmably to a peptide or protein sensor, an antibody sensor, a carbohydrate sensor, or a cell sensor;

wherein the peptide or protein sensor comprises an electrophoresis tag or micro-assay, or protein chip;

the antibody sensor comprises a phagotope biochip;

the carbohydrate sensor comprises a glycochip, or a whole blood glucose monitoring system; and

the cell sensor comprises a bionic chip for cell-growth.

35. The apparatus of claim 34 wherein:

the sensor array couples further to a vector or virus vector sensor comprising a micro-array or assay with known sequenced virus attached, or a micro-array or assay that detects homologs; and

to a DNA sensor comprising a micro-array or assay.