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SMMR (small molecule metabolite reporters) for use as in vivo glucose biosensors

  • US 20070110672A1
  • Filed: 06/26/2006
  • Published: 05/17/2007
  • Est. Priority Date: 12/24/2003
  • Status: Active Grant
First Claim
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1. A small molecule metabolite reporter compound of the following formula:

  • embedded image wherein D is a heteroatom;

    R1 and R2 are different and are selected from the group consisting of H, OH, NH2, NO2, OCH3, N(CH3)2, A, or, R1 and R2, taken together with the ring to which they are attached, form R7;

    R3 and R4 are different and are selected from the group consisting of H, embedded image

    OH, B(OH)2, M, or R3 and R4, taken together with the ring to which they are attached, form R8;

    R5 and R6 are different and are selected from the group consisting of H or embedded image

    wherein Q is H, COOH, B(OH)2, or M;

    A is embedded imageR7 is embedded imageR8 is embedded imageM is embedded imageL, when present, is an amino-containing linking moiety;

    R1 and R2, and R3 and R4, are adjacent to each other on the rings on which they reside; and

    at least one boronic acid moiety is present; and

    salts thereof.

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