Medical devices with proteasome inhibitors for the treatment of restenosis
First Claim
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1. A medical device for delivering an anti-restenotic composition comprising:
- a stent having a generally cylindrical shape comprising an outer surface, an inner surface, a first open end, a second open end and wherein at least one of said inner or said outer surfaces are adapted to deliver an anti-restenotic effective amount of at least one proteasome inhibitor to a tissue within a mammal.
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Abstract
Methods, compositions and devices for inhibiting restenosis are provided. Specifically, proteasome inhibitor compositions and medical devices useful for the site specific delivery of proteasome inhibitors are disclosed. In one embodiment the medical device is a vascular stent coated with a proteasome inhibitor selected from the group consisting of a boronic acid, a C-terminal peptide aldehyde and derivatives and analogues thereof. In another embodiment an injection catheter for delivery an anti-restenotic effective amount of proteasome inhibitor to the adventitia is provided.
15 Citations
25 Claims
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1. A medical device for delivering an anti-restenotic composition comprising:
a stent having a generally cylindrical shape comprising an outer surface, an inner surface, a first open end, a second open end and wherein at least one of said inner or said outer surfaces are adapted to deliver an anti-restenotic effective amount of at least one proteasome inhibitor to a tissue within a mammal. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 17, 18)
- 14. A vascular stent comprising a polymeric coating containing an anti-restenotic effective amount of a proteasome inhibitor.
- 20. A method for inhibiting restenosis in a mammal comprising the site specific delivery of at least one proteasome inhibitor.
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25. A method for inhibiting restenosis comprising providing a vascular stent having a coating comprising an anti-restenotic effective amount of bortezomib.
Specification