Method of enhancing and/or inducing neuronal migration using erythropoietin
First Claim
1. A method of enhancing multipotent neural stem cell and/or multipotent neural stem cell progeny migration in a subject comprising administering an erythropoietin and at least one other growth factor to a subject in an amount effective to enhance migration of multipotent neural stem cells and/or multipotent neural stem cell progeny.
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Abstract
Methods are described for the enhancement and/or induction of migration of neural stem cells or neuronal progenitor cells. Multipotent neural stem cells are exposed to erythropoietin which enhances the migration of multipotent neural stem cells and neuronal progenitor cells. The erythropoietin may be exogenously applied to the multipotent neural stem cells, or alternatively, the cells can be subjected to hypoxic insult which induces the cells to express erythropoietin. In a preferred embodiment, additional growth factors, such as EGF and prolactin, are utilized.
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Citations
31 Claims
- 1. A method of enhancing multipotent neural stem cell and/or multipotent neural stem cell progeny migration in a subject comprising administering an erythropoietin and at least one other growth factor to a subject in an amount effective to enhance migration of multipotent neural stem cells and/or multipotent neural stem cell progeny.
- 16. A method of inducing the migration of multipotent neural stem cells and/or multipotent stem cell progeny comprising exogenously adding to said multipotent neural stem cells and/or multipotent neural stem cell progeny an amount of an erythropoietin and at least one other growth factor effective to cause the migration of multipotent neural stem cells and/or multipotent neural stem cell progeny.
- 24. A method for inducing migration of multipotent neural stem cells and/or multipotent neural stem cell progeny, comprising exposing said multipotent neural stem cells and/or multipotent neural stem cell progeny to hypoxic conditions to induce expression of erythropoietin and exogenously adding at least one other growth factor in an amount effective to induce migration.
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