Iontophoresis device

• US 20070112294A1
• Filed: 09/14/2006
• Published: 05/17/2007
• Est. Priority Date: 09/14/2005
• Status: Abandoned Application

• Current Assignee: TTI Ellebeau, Inc. (Ease Asset Management Ltd.)
• Original Assignee: Transcutaneous Technologies, Inc.
• Inventors: Nakayama, Mizuo, Matsumura, Takehiko, Akiyama, Hidero, Kanamura, Kiyoshi, Matsumura, Akihiko
• Application Number:
  US11/522,496
• Publication Number:
  US 20070112294A1
• Time in Patent Office: Days
• US Class Current: 604/20
• CPC Class Codes: A61N 1/30 Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis

Abstract

An iontophoresis device may be capable of preventing the generation of gas or ions upon energization, and/or may be capable of preventing the alteration of active agent ions due to an electrode reaction. Energization from an electrode to an active agent reservoir may be performed through an ionic liquid. The ionic liquid may include an anion such as PF6-, BF4-, AlCl4-, ClO4-, a hydrogen sulfate ion, bis-trifluoro-alkyl-sulfonyl-imide, or trifluoro-methane-sulfonate, and a cation such as an imidazolium derivative, a pyridinium derivative, a piperidinium derivative, a pyrolidinium derivative, and a tetra-alkyl-ammonium derivative.

Claims

1. An iontophoresis device, comprising:

an active electrode assembly comprising;

a first electrode supplied with an electric potential of a first polarity;

an ionic liquid reservoir that holds an ionic liquid in contact with the first electrode; and

an active agent reservoir placed on an outer surface of the ionic liquid reservoir, the active agent reservoir holding active agent ions of the first polarity.

2. The iontophoresis device according to claim 1, wherein the active electrode assembly further comprises an ion exchange membrane of the first polarity on an outer surface of the active agent reservoir.

3. The iontophoresis device according to claim 1, wherein:

the active agent reservoir holds an active agent solution that comprises the active agent ions and active agent counter ions of a second polarity; and

the active electrode assembly further comprises a semi-permeable membrane that selectively allows passage of at least the active agent counter ions between the active agent reservoir and the ionic liquid reservoir.

4. The iontophoresis device according to claim 1, wherein an electrolyte having an oxidation-reduction potential lower than that of the ionic liquid is dissolved in the ionic liquid.

5. The iontophoresis device according to claim 1, wherein the ionic liquid comprises an imidazorium derivative, a pyridinium derivative, a piperidinium derivative, a pyrrolidinium derivative, or a tetra-alkyl-ammonium derivative.

6. The iontophoresis device according to claim 1, wherein the ionic liquid is hydrophobic.

7. The iontophoresis device according to claim 6, wherein the active electrode assembly further comprises an ion exchange membrane of the first polarity on an outer surface of the active agent reservoir.

8. The iontophoresis device according to claim 6, wherein:

the active agent reservoir holds an active agent solution that comprises the active agent ions and active agent counter ions of a second polarity; and

the active electrode assembly further comprises a semi-permeable membrane that selectively allows passage of at least the active agent counter ions between the active agent reservoir and the ionic liquid reservoir.

9. The iontophoresis device according to claim 6, wherein an electrolyte having an oxidation-reduction potential lower than that of the ionic liquid is dissolved in the ionic liquid.

10. The iontophoresis device according to claim 6, wherein the ionic liquid comprises an imidazorium derivative, a pyridinium derivative, a piperidinium derivative, a pyrrolidinium derivative, or a tetra-alkyl-ammonium derivative.

11. The iontophoresis device according to claim 6, wherein the ionic liquid comprises bis-trifluoroalkyl-sulphonyl-imide.

12. The iontophoresis device according to claim 11, wherein the active electrode assembly further comprises an ion exchange membrane of the first polarity on an outer surface of the active agent reservoir.

13. The iontophoresis device according to claim 11, wherein:

the active agent reservoir holds an active agent solution that comprises the active agent ions and active agent counter ions of a second polarity; and

the active electrode assembly further comprises a semi-permeable membrane that selectively allows passage of at least the active agent counter ions between the active agent reservoir and the ionic liquid reservoir.

14. The iontophoresis device according to claim 11, wherein an electrolyte having an oxidation-reduction potential lower than that of the ionic liquid is dissolved in the ionic liquid.

15. The iontophoresis device according to claim 11, wherein the ionic liquid comprises an imidazorium derivative, a pyridinium derivative, a piperidinium derivative, a pyrrolidinium derivative, or a tetra-alkyl-ammonium derivative.

16. The iontophoresis device according to claim 15, wherein the active electrode assembly further comprises an ion exchange membrane of the first polarity on an outer surface of the active agent reservoir.

17. The iontophoresis device according to claim 15, wherein:

the active agent reservoir holds an active agent solution that comprises the active agent ions and active agent counter ions of a second polarity; and

the active electrode assembly further comprises a semi-permeable membrane that selectively allows passage of at least the active agent counter ions between the active agent reservoir and the ionic liquid reservoir.

18. The iontophoresis device according to claim 15, wherein an electrolyte having an oxidation-reduction potential lower than that of the ionic liquid is dissolved in the ionic liquid.

19. The iontophoresis device according to claim 18, wherein the active electrode assembly further comprises an ion exchange membrane of the first polarity on an outer surface of the active agent reservoir.

20. The iontophoresis device according to claim 18, wherein:

the active agent reservoir holds an active agent solution that comprises the active agent ions and active agent counter ions of a second polarity; and

the active electrode assembly further comprises a semi-permeable membrane that selectively allows passage of at least the active agent counter ions between the active agent reservoir and the ionic liquid reservoir.

21. The iontophoresis device according to claim 20, wherein the active electrode assembly further comprises an ion exchange membrane of the first polarity on an outer surface of the active agent reservoir.

22. The iontophoresis device according to claim 1, wherein:

the active agent reservoir comprises an ion exchange membrane of the first polarity doped with the active agent ions;

the active electrode assembly further comprises an electrolyte solution reservoir that holds an electrolyte solution, the electrolyte solution reservoir placed on an outer surface of the ionic liquid reservoir, and a semi-permeable membrane that selectively allows passage of at least ions of a second polarity of the electrolyte solution reservoir, the semi-permeable membrane placed between the ionic liquid reservoir and the active agent reservoir; and

the active agent reservoir is placed on an outer surface of the electrolyte solution reservoir.

23. The iontophoresis device according to claim 1, further comprising:

a counter electrode assembly comprising;

a second electrode supplied with an electric potential of the second polarity;

a second ionic liquid reservoir that holds an ionic liquid in contact with the second electrode; and

a second electrolyte solution reservoir that holds an electrolyte solution, the second electrolyte solution reservoir placed on an outer surface of the second ionic liquid reservoir.

24. An iontophoresis device comprising:

an active electrode assembly comprising;

a first electrode; and

an active agent reservoir that holds active agent ions of a first polarity, the active agent ions being administered to a living body by an electric potential of a first polarity applied to the first electrode; and

a counter electrode assembly comprising;

a second electrode supplied with an electric potential of a second polarity;

a second ionic liquid reservoir that holds an ionic liquid in contact with the second electrode; and

an electrolyte solution reservoir that holds an electrolyte solution, the electrolyte solution reservoir placed on an outer surface of the second ionic liquid reservoir.