Selection system, dispensing system and treatment with a one-a-day combination pill for hypertension, hypercholesterolemia, hypertriglyceridemia and anti-platelet treatment

• US 20070112593A1
• Filed: 02/07/2006
• Published: 05/17/2007
• Est. Priority Date: 11/14/2005
• Status: Abandoned Application

• Current Assignee: Daya Medicals, Inc. (Canada), DKMC, Inc., Rxcera Pharmaceutical, Inc.
• Original Assignee: Rxcera Pharmaceutical, Inc.
• Inventors: Daya, Kantilal
• Application Number:
  US11/348,786
• Publication Number:
  US 20070112593A1
• Time in Patent Office: Days
• US Class Current: 705/2
• CPC Class Codes: A61J 7/04 Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
• CPC Class Codes: G06Q 10/06 Resources, workflows, human or project management; Enterprise or organisation planning; Enterprise or organisation modelling
• CPC Class Codes: G06Q 40/08 Insurance
• CPC Class Codes: G16H 20/13 delivered from dispensers
• CPC Class Codes: G16H 70/40 relating to drugs, e.g. their side effects or intended usage

Abstract

The present invention relates to a selection system, a dispensing system and a process using a matrix enabling a physician to select one of the plurality of one-a-day combinatory pills. The system and method uses matrices of a plurality of one-a-day pill formulations (a total of 144-177 combinatory pill formulas, or representative indicia thereof). The matrices enable the physician to pick one selected combinatory pill from the 177 formulations, adjust (titrate) dosages over time and use the matrices as an educational tool to motivate the patient. The use of a single daily pill with various commonly prescribed dosages of preventive medications greatly enhances compliance. The information processing system employs a computer or other electronic device or the physician may use printed substrates showing the matrices. The dispensing system includes a dispensing interface.

Claims

1. A system for selecting one combination one-a-day pill from a plurality of combination pills for treating a patient with a one-a-day, orally administered, pill having a combination of medicaments for hypertension, hypercholesterolemia, hypertriglyceridemia and an anti-platelet medication over a weekly, monthly or quarterly period of time, comprising:

a printed substrate having at least three subparts, each subpart movably disposed with respect to the other subparts;

a first subpart substrate listing indicia representing a first plurality of one-a-day pill formulations consisting essentially of;

a respective first plurality of one-a-day pills each with a therapeutically effective amount of aspirin or clopidogrel bisulfate plus a statin of about 10 mg, a diuretic in a range of about 25 mg to 50 mg, an ace inhibitor in a range of about 10 mg to 40 mg; and

a medicament used to lower triglycerides in a range of about 67 mg to 200 mg;

a second subpart substrate listing indicia representing a second plurality of one-a-day pill formulations consisting essentially of;

a respective second plurality of one-a-day pills each with a therapeutically effective amount of aspirin or clopidogrel bisulfate plus a statin in a range of about 10 mg to 20 mg, a diuretic in a range of about 25 mg to 50 mg, an ace inhibitor in a range of about 10 mg to 40 mg; and

a medicament used to lower triglycerides in a range of about 67 mg to 200 mg;

a third subpart substrate listing indicia representing a third plurality of one-a-day pill formulations consisting essentially of;

a respective third plurality of one-a-day pills each with a therapeutically effective amount of aspirin or clopidogrel bisulfate plus a statin in a range of about 10 mg to 40 mg, a diuretic in a range of about 25 mg to 50 mg, and an ace inhibitor in a range of about 10 mg to 40 mg;

wherein said respective indicia for said statin, said diuretic, said ace inhibitor, and said medicament used to lower triglycerides represents statin unitized in said ranges and in commonly prescribed dosages;

said diuretic unitized in and in commonly prescribed dosages; and

said ace inhibitor unitized in said ranges and in commonly prescribed dosages; and

said medicament used to lower triglycerides unitized in said ranges and in commonly prescribed dosages;

means for moving said first, second and third subparts independent of each other and facilitating selection of titrated dosages of said combination pills over said weekly, monthly or quarterly period of time.

2. A system for selecting one combination one-a-day pill as claimed in claim 1 wherein said commonly prescribed dosages for said statin being about 10, 20, 40 and 80 mg dosages;

said commonly prescribed dosages for said diuretic unitized being about 25 and 50 mg dosages; and

said commonly prescribed dosages for said ace inhibitor unitized being about 10, 20 and 40 mg dosages.

3. A system for selecting one combination one-a-day pill as claimed in claim 2 wherein said medicament used to lower triglycerides being a fenofibrate in a range of about 67 mg to 200 mg.

4. A system for selecting one combination one-a-day pill as claimed in claim 3 wherein said commonly prescribed dosages for said fenofibrate being about 67, 160 and 200 mg dosages.

5. A system for selecting one combination one-a-day pill as claimed in claim 1 wherein said indicia representing said first plurality of one-a-day pill formulations is a first color;

and said indicia representing said second plurality of one-a-day pill formulations is a second color; and

said indicia representing said third plurality of one-a-day pill formulations is a third color, said first, second and third colors begin distinctively different.

6. A system for selecting one combination one-a-day pill as claimed in claim 4 wherein said indicia representing said first plurality of one-a-day pill formulations is a first color;

and said indicia representing said second plurality of one-a-day pill formulations is a second color; and

said indicia representing said third plurality of one-a-day pill formulations is a third color, said first, second and third colors begin distinctively different.

7. A system for selecting one combination one-a-day pill as claimed in claim 1 wherein said substrate has a fourth subpart substrate listing indicia representing a fourth plurality of one-a-day pill formulations consisting essentially of:

a respective fourth plurality of one-a-day pills a first subgroup of which includes a therapeutically effective amount of aspirin or clopidogrel bisulfate plus a statin in a range of about 10 mg to 80 mg, a diuretic in a range of about 25 mg to 80 mg, an ace inhibitor in a range of about 10 mg to 40 mg and a medicament used to lower triglycerides in a range of about 67 mg to 200 mg; and

a second subgroup of which includes a therapeutically effective amount of aspirin or clopidogrel bisulfate plus a statin in a range of about 10 mg to 80 mg, a diuretic in a range of about 25 mg to 80 mg, and an ace inhibitor in a range of about 10 mg to 40 mg.

8. A system for selecting one combination one-a-day pill as claimed in claim 7 wherein said substrate has a fifth subpart substrate listing indicia representing a fifth plurality of one-a-day pill formulations consisting essentially of:

a respective fifth plurality of one-a-day pills each with a therapeutically effective amount of aspirin or clopidogrel bisulfate plus a statin in a range of about 10 mg to 80 mg, an ace inhibitor in a range of about 10 mg to 40 mg and a medicament used to lower triglycerides in a range of about 67 mg to 200 mg;

said means for moving also moving said first, second, third, fourth and fifth subparts independent of each other and facilitating selection of titrated dosages of said combination pills over said weekly, monthly or quarterly period of time.

9. A system for selecting one combination one-a-day pill as claimed in claim 8 wherein said medicament used to lower triglycerides being a fenofibrate in a range of about 67 mg to 200 mg.

10. A system for selecting one combination one-a-day pill as claimed in claim 9 wherein said commonly prescribed dosages for said fenofibrate being about 67, 160 and 200 mg dosages.

11. A system for selecting one combination one-a-day pill as claimed in claim 10 wherein said indicia representing said first plurality of one-a-day pill formulations is a first color;

and said indicia representing said second plurality of one-a-day pill formulations is a second color; and

said indicia representing said third plurality of one-a-day pill formulations is a third color, said first, second and third colors begin distinctively different.

12. A system for selecting one combination one-a-day pill as claimed in claim 1 wherein said first, second and third subpart substrates are movably coupled together, via said means for moving, by one of hinges, spiral bindings or tabs slidably disposed in slots.

13. A system for selecting one combination one-a-day pill as claimed in claim 11 wherein said first, second, third and fourth subpart substrates are movably coupled together, via said means for moving, by one of hinges, spiral bindings or tabs slidably disposed in slots.

14. A system for selecting one combination pill from a plurality of combination pills for treating a patient with a one-a-day, orally administered, pill having a combination of medicaments for hypertension, hypercholesterolemia, hypertriglyceridemia and an anti-platelet medication over a weekly, monthly or quarterly period of time, comprising:

a printed substrate having at least three subparts, each subpart movably disposed with respect to the other subparts;

a first subpart substrate listing indicia representing a first plurality of one-a-day pill formulations consisting essentially of;

a respective first plurality of one-a-day pills each with a therapeutically effective amount of aspirin or clopidogrel bisulfate plus a statin of about 10 mg, a diuretic in a range of about 25 mg to 50 mg, an ace inhibitor in a range of about 10 mg to 40 mg; and

a fenofibrate in a range of about 67 mg to 200 mg;

a second subpart substrate listing indicia representing a second plurality of one-a-day pill formulations consisting essentially of;

a respective second plurality of one-a-day pills each with a therapeutically effective amount of aspirin or clopidogrel bisulfate plus a statin in a range of about 10 mg to 20 mg, a diuretic in a range of about 25 mg to 50 mg, an ace inhibitor in a range of about 10 mg to 40 mg; and

a fenofibrate in a range of about 67 mg to 200 mg;

a third subpart substrate listing indicia representing a third plurality of one-a-day pill formulations consisting essentially of;

a respective third plurality of one-a-day pills each with a therapeutically effective amount of aspirin or clopidogrel bisulfate plus a statin in a range of about 10 mg to 40 mg, a diuretic in a range of about 25 mg to 50 mg, and an ace inhibitor in a range of about 10 mg to 40 mg;

wherein said respective indicia for said statin, said diuretic, said ace inhibitor, and fenofibrate represents statin unitized in said ranges of about 10, 20, 40 and 80 mg dosages;

said diuretic unitized in said range in about 25 and 50 mg dosages; and

said ace inhibitor unitized in said ranges of about 10, 20 and 40 mg dosages, and said fenofibrate unitized in said ranges of about 67, 160 and 200 mg dosages;

means for moving said first, second and third subparts independent of each other and facilitating selection of titrated dosages of said combination pills over said weekly, monthly or quarterly period of time.

15. An information processing system for selecting one combination one-a-day pill from a plurality of combination pills for treating a patient with a one-a-day, orally administered, pill having a combination of medicaments for hypertension, hypercholesterolemia, hypertriglyceridemia and an anti-platelet medication comprising:

a computer having a memory, a display screen and operator input controls, said memory storing at least first, second and third display matrices representing respective first, second and third pluralities of one-a-day pill formulations;

means for displaying, upon a first operator input, indicia from said first matrix representing said first plurality of one-a-day pill formulations consisting essentially of;

a respective first plurality of one-a-day pills each with a therapeutically effective amount of aspirin or clopidogrel bisulfate plus a statin of about 10 mg, a diuretic in a range of about 25 mg to 50 mg, an ace inhibitor in a range of about 10 mg to 40 mg; and

a medicament used to lower triglycerides in a range of about 67 mg to 200 mg;

means for displaying, upon a second operator input, indicia from said second matrix representing said second plurality of one-a-day pill formulations consisting essentially of;

a respective second plurality of one-a-day pills each with a therapeutically effective amount of aspirin or clopidogrel bisulfate plus a statin in a range of about 10 mg to 20 mg, a diuretic in a range of about 25 mg to 50 mg, an ace inhibitor in a range of about 10 mg to 40 mg; and

a medicament used to lower triglycerides in a range of about 67 mg to 200 mg;

means for displaying, upon a third operator input, indicia from said third matrix representing said third plurality of one-a-day pill formulations consisting essentially of;

a respective third plurality of one-a-day pills each with a therapeutically effective amount of aspirin or clopidogrel bisulfate plus a statin in a range of about 10 mg to 40 mg, a diuretic in a range of about 25 mg to 50 mg, and an ace inhibitor in a range of about 10 mg to 40 mg;

wherein said respective indicia for said statin, said diuretic, said ace inhibitor, and said medicament used to lower triglycerides represents statin unitized in said ranges and in commonly prescribed dosages;

said diuretic unitized in said ranges and in commonly prescribed dosages; and

said ace inhibitor unitized in said ranges and in commonly prescribed dosages; and

said medicament used to lower triglycerides unitized in said ranges and in commonly prescribed dosages; and

an output generator designating a selected one of said one-a-day combination pill upon an operator output selection, said selected one of said one-a-day combination pill being selected from said first, second and third matrices.

16. An information processing system for selecting one combination one-a-day pill as claimed in claim 15 wherein said commonly prescribed dosages for said statin being about 10, 20, 40 and 80 mg dosages;

said commonly prescribed dosages for said diuretic unitized being about 25 and 50 mg dosages; and

said commonly prescribed dosages for said ace inhibitor unitized being about 10, 20 and 40 mg dosages.

17. An information processing system for selecting one combination one-a-day pill as claimed in claim 16 wherein said medicament used to lower triglycerides being a fenofibrate in a range of about 67 mg to 200 mg.

18. An information processing system for selecting one combination one-a-day pill as claimed in claim 17 wherein said commonly prescribed dosages for said fenofibrate being about 67, 160 and 200 mg dosages.

19. An information processing system for selecting one combination one-a-day pill as claimed in claim 15 including means for providing a supplemental display listing indicia representing a full formulation of said selected one of said combination one-a-day pill, said selected one of said one-a-day pill being represented in said first, second or third matrices.

20. An information processing system for selecting one combination one-a-day pill as claimed in claim 15 including a dispensing system, said dispensing system including respective storage containers for each formulation of each one-a-day combination pill and a corresponding inventory of one-a-day combination pills therein, a controlled pill dispensing interface accepting, from said output generator, said selected one of said one-a-day combination pill data and dispensing, from the corresponding storage container, a number of said selected one of said one-a-day combination pills.

21. An information processing system for selecting one combination one-a-day pill as claimed in claim 20 wherein said output generator includes a printer outputting a print version of indicia representing said selected one of said one-a-day combination pill and said dispensing system includes a pre-dispensing display showing indicia representing a selected storage container and includes an operator confirmation control which permits said operator to accept or reject said selected storage container dependent upon said print version of indicia representing said selected one of said one-a-day combination pill and said pre-dispensing display.

22. An information processing system for selecting one combination one-a-day pill as claimed in claim 15 wherein said memory stores a fourth matrix representing a fourth plurality of one-a-day pill formulations;

means for displaying, upon a fourth operator input, indicia representing said fourth plurality of one-a-day pill formulations consisting essentially of;

a respective fourth plurality of one-a-day pills a first subgroup of which includes a therapeutically effective amount of aspirin or clopidogrel bisulfate plus a statin in a range of about 10 mg to 80 mg, a diuretic in a range of about 25 mg to 80 mg, an ace inhibitor in a range of about 10 mg to 40 mg and a medicament used to lower triglycerides in a range of about 67 mg to 200 mg; and

a second subgroup of which includes a therapeutically effective amount of aspirin or clopidogrel bisulfate plus a statin in a range of about 10 mg to 80 mg, a diuretic in a range of about 25 mg to 80 mg, and an ace inhibitor in a range of about 10 mg to 40 mg.

23. An information processing system for selecting one combination one-a-day pill as claimed in claim 22 wherein said memory stores a fifth matrix representing a fifth plurality of one-a-day pill formulations;

means for displaying, upon a fifth operator input, indicia representing said fifth plurality of one-a-day pill formulations consisting essentially of;

a respective fifth plurality of one-a-day pills each with a therapeutically effective amount of aspirin or clopidogrel bisulfate plus a statin in a range of about 10 mg to 80 mg, an ace inhibitor in a range of about 10 mg to 40 mg and a medicament used to lower triglycerides in a range of about 67 mg to 200 mg.

24. An information processing system for selecting one combination one-a-day pill as claimed in claim 23 wherein said medicament used to lower triglycerides being a fenofibrate in a range of about 67 mg to 200 mg.

25. An information processing system for selecting one combination one-a-day pill as claimed in claim 24 wherein said commonly prescribed dosages for said fenofibrate being about 67, 160 and 200 mg dosages.

26. An information processing system for selecting one combination one-a-day pill as claimed in claim 25 wherein said output generator lists said selected one of said one-a-day combination pill from said first, second, third, fourth and fifth matrices.

27. A dispensing system for selecting one combination one-a-day pill from a plurality of combination pills for treating a patient with a one-a-day, orally administered, pill having a combination of medicaments for hypertension, hypercholesterolemia, hypertriglyceridemia and an anti-platelet medication comprising:

a dispensing system, said dispensing system including respective storage containers for each formulation of each one-a-day combination pill and a corresponding inventory of one-a-day combination pills therein,

said respective storage containers having first, second and third pluralities of one-a-day pill formulations;

said first plurality of one-a-day pill formulations consisting essentially of one-a-day pills each with a therapeutically effective amount of aspirin or clopidogrel bisulfate plus a statin of about 10 mg, a diuretic in a range of about 25 mg to 50 mg, an ace inhibitor in a range of about 10 mg to 40 mg; and

a medicament used to lower triglycerides in a range of about 67 mg to 200 mg;

said second plurality of one-a-day pill formulations consisting essentially of one-a-day pills each with a therapeutically effective amount of aspirin or clopidogrel bisulfate plus a statin in a range of about 10 mg to 20 mg, a diuretic in a range of about 25 mg to 50 mg, an ace inhibitor in a range of about 10 mg to 40 mg; and

a medicament used to lower triglycerides in a range of about 67 mg to 200 mg;

said third plurality of one-a-day pill formulations consisting essentially of one-a-day pills each with a therapeutically effective amount of aspirin or clopidogrel bisulfate plus a statin in a range of about 10 mg to 40 mg, a diuretic in a range of about 25 mg to 50 mg, and an ace inhibitor in a range of about 10 mg to 40 mg;

wherein said statin, diuretic, ace inhibitor, and medicament used to lower triglycerides represents are unitized such that said statin is unitized in said ranges and in commonly prescribed dosages;

said diuretic is unitized in said ranges and in commonly prescribed dosages; and

said ace inhibitor is unitized in said ranges and in commonly prescribed dosages; and

said medicament used to lower triglycerides is unitized in said ranges and in commonly prescribed dosages; and

a controlled pill dispensing interface accepting a data input for a selected one of said one-a-day combination pill and dispensing, from the corresponding storage container, a number of said selected one of said one-a-day combination pills.

28. A dispensing system for selecting one combination one-a-day pill as claimed in claim 27 wherein said commonly prescribed dosages for said statin is about 10, 20, 40 and 80 mg dosages;

said commonly prescribed dosages for said diuretic unitized is about 25 and 50 mg dosages; and

said commonly prescribed dosages for said ace inhibitor unitized is about 10, 20 and 40 mg dosages.

29. A dispensing system for selecting one combination one-a-day pill as claimed in claim 28 wherein said medicament used to lower triglycerides is a fenofibrate in a range of about 67 mg to 200 mg.

30. A dispensing system for selecting one combination one-a-day pill as claimed in claim 29 wherein said commonly prescribed dosages for said fenofibrate is about 67, 160 and 200 mg dosages.

31. A dispensing system for selecting one combination one-a-day pill as claimed in claim 27 including means for providing a display listing indicia representing said selected one of said combination one-a-day pill.

32. A dispensing system for selecting one combination one-a-day pill as claimed in claim 27 including a pill bottle, each said storage container having a pill dispensing port thereon, and said controlled pill dispensing interface including:

means to position said pill bottle relative to the storage container for said selected one of said one-a-day combination pill;

means to controllably open and close a corresponding pill dispensing port for said storage container for said selected one of said one-a-day combination pill thereby to release said number of said selected one of said one-a-day combination pill into said pill bottle.

33. A dispensing system for selecting one combination one-a-day pill as claimed in claim 32 including a pre-dispensing display showing indicia representing said selected storage container and including an operator confirmation control which permits said operator to accept or reject said selected storage container dependent upon script instructions for said patient.

34. A dispensing system for selecting one combination one-a-day pill as claimed in claim 32 including a label generator for printing indicia representing said selected one of said one-a-day combination pill.

35. A dispensing system for selecting one combination one-a-day pill as claimed in claim 27 including respective storage containers for a fourth plurality of one-a-day pill formulations;

said fourth plurality of one-a-day pill formulations consisting essentially of a first subgroup of combination pills which includes a therapeutically effective amount of aspirin or clopidogrel bisulfate plus a statin in a range of about 10 mg to 80 mg, a diuretic in a range of about 25 mg to 80 mg, an ace inhibitor in a range of about 10 mg to 40 mg and a medicament used to lower triglycerides in a range of about 67 mg to 200 mg; and

a second subgroup of combination pills which includes a therapeutically effective amount of aspirin or clopidogrel bisulfate plus a statin in a range of about 10 mg to 80 mg, a diuretic in a range of about 25 mg to 80 mg, and an ace inhibitor in a range of about 10 mg to 40 mg.

36. A dispensing system for selecting one combination one-a-day pill as claimed in claim 35 including respective storage containers for a fifth plurality of one-a-day pill formulations;

said fifth plurality of one-a-day pill formulations consisting essentially of one-a-day pills each with a therapeutically effective amount of aspirin or clopidogrel bisulfate plus a statin in a range of about 10 mg to 80 mg, an ace inhibitor in a range of about 10 mg to 40 mg and a medicament used to lower triglycerides in a range of about 67 mg to 200 mg.

37. A dispensing system for selecting one combination one-a-day pill as claimed in claim 36 wherein said medicament used to lower triglycerides being a fenofibrate in a range of about 67 mg to 200 mg.

38. A dispensing system for selecting one combination one-a-day pill as claimed in claim 37 wherein said commonly prescribed dosages for said fenofibrate being about 67, 160 and 200 mg dosages.

39. A process to mitigate coronary heart disease, cardiovascular disease or diabetes mellitus with a one-a-day, orally administered, pill selected from a matrix, the process comprising:

selecting a one-a-day pharmaceutical combination from a plurality of one-a-day pill formulations listed on a substrate in a matrix form, said matrix listing;

a plurality of one-a-day pill formulations, each one-a-day pill formulation including a therapeutically effective amount of aspirin or clopidogrel bisulfate plus a statin in a range of 10 mg to 80 mg, a diuretic in a range of 25 mg to 80 mg, and an ace inhibitor in a range of 10 mg to 40 mg;

wherein said statin is unitized in said range in about 10, 20, 40 and 80 mg dosages;

said diuretic is unitized in said range in about 25, 50 and 80 mg dosages; and

said ace inhibitor is unitized in said range in about 10, 20 and 40 mg dosages.

40. A process as claimed in claim 39 wherein said plurality of one-a-day pill formulations listed on said matrix includes:

a further plurality of one-a-day pills, each one of said further plurality of one-a-day pill formulations including a therapeutically effective amount of aspirin or clopidogrel bisulfate plus a statin in a range of 10 mg to 20 mg, a diuretic in a range of 25 mg to 50 mg, an ace inhibitor in a range of 10 mg to 40 mg and a fenofibrate in a range of about 67 mg to 200 mg; and

wherein said fenofibrate is unitized in about 67, 160 and 200 mg dosages.

41. A process as claimed in claim 39 wherein said one-a-day pill formulations listed in said matrix includes:

one-a-day pill formulations with a therapeutically effective amount of aspirin or clopidogrel bisulfate plus a statin in a range of 10 mg to 80 mg, an ace inhibitor in a range of 10 mg to 40 mg and a fenofibrate in a range of about 67 mg to 200 mg; and

wherein said fenofibrate is unitized in about 67, 160 and 200 mg dosages.

42. A process to mitigate coronary heart disease, cardiovascular disease or diabetes mellitus with a one-a-day, orally administered, pill selected from a matrix, comprising:

selecting a one-a-day pill formulation from a plurality of formulations listed on a substrate in a matrix form, said matrix listing;

a plurality of one-a-day pill formulations each with a therapeutically effective amount of aspirin or clopidogrel bisulfate plus a statin in a range of 10 mg to 40 mg, a diuretic in a range of 25 mg to 50 mg, and an ace inhibitor in a range of 10 mg to 40 mg;

a further plurality of one-a-day pill formulations each with a therapeutically effective amount of aspirin or clopidogrel bisulfate plus a statin in a range of 10 mg to 20 mg, a diuretic in a range of 25 mg to 50 mg, an ace inhibitor in a range of 10 mg to 40 mg and a fenofibrate in a range of about 67 mg to 200 mg;

wherein said statins are unitized in said range in about 10 and 20 mg dosages;

said diuretic is unitized in said range in about 25 and 50 mg dosages;

said ace inhibitor is unitized in said range in about 10, 20 and 40 mg dosages; and

said fenofibrate is unitized in said range in about 67, 160 and 200 mg dosages.

43. A process to mitigate coronary heart disease, cardiovascular disease or diabetes mellitus with a one-a-day, orally administered, pill selected from a matrix, comprising:

selecting a one-a-day pill formulation from a plurality of formulations using representative indicia listed on a substrate in a matrix form, said matrix listing;

a plurality of one-a-day pill formulations, each one-a-day pill with a therapeutically effective amount of aspirin or clopidogrel bisulfate plus a statin in a range of 10 mg to 80 mg, a diuretic in a range of 25 mg to 80 mg, and an ace inhibitor in a range of 10 mg to 40 mg;

a further plurality of one-a-day pill formulations, each one-a-day pill with a therapeutically effective amount of aspirin or clopidogrel bisulfate plus a statin in a range of 10 mg to 80 mg, an ace inhibitor in a range of 10 mg to 40 mg and a medicament used to lower triglycerides in a range of about 67 mg to 200 mg;

wherein said statin is unitized in said range in about 10, 20, 40 and 80 mg dosages;

said diuretic is unitized in said range in about 25, 50 and 80 mg dosages;

said ace inhibitor is unitized in said range in about 10, 20 and 40 mg dosages; and

said medicament used to lower triglycerides is unitized in said range in about 67, 160 and 200 mg dosages.

44. A process to mitigate coronary heart disease, cardiovascular disease or diabetes mellitus with a one-a-day, orally administered, pill selected from a matrix, comprising:

selecting a one-a-day pill formulation from a plurality of formulations listed on a substrate in a matrix form, said matrix listing;

a plurality of one-a-day pill formulations, each one-a-day pill with a therapeutically effective amount of aspirin or clopidogrel bisulfate plus a statin in a range of 10 mg to 80 mg, a diuretic in a range of 25 mg to 80 mg, and an ace inhibitor in a range of 10 mg to 40 mg;

a further plurality of one-a-day pill formulations, each one-a-day pill with a therapeutically effective amount of aspirin or clopidogrel bisulfate plus a statin in a range of 10 mg to 20 mg, a diuretic in a range of 25 mg to 50 mg, an ace inhibitor in a range of 10 mg to 40 mg and a fenofibrate in a range of about 67 mg to 200 mg;

an additional plurality of one-a-day pill formulations, each one-a-day pill with a therapeutically effective amount of aspirin or clopidogrel bisulfate plus a statin in a range of 10 mg to 80 mg, an ace inhibitor in a range of 10 mg to 40 mg and a fenofibrate in a range of about 67 mg to 200 mg;

wherein said statin is unitized in said range in about 10, 20, 40 and 80 mg dosages;

said diuretic is unitized in said range in about 25, 50 and 80 mg dosages;

said ace inhibitor is unitized in said range in about 10, 20 and 40 mg dosages; and

said fenofibrate is unitized in said range in about 67, 160 and 200 mg dosages.

45. A process to mitigate coronary heart disease, cardiovascular disease or diabetes mellitus with a one-a-day, orally administered, pill selected from a matrix, comprising:

selecting a one-a-day pill formulation from a plurality of formulations listed on a substrate in a matrix form, said matrix listing;

a first plurality of one-a-day pills with a therapeutically effective amount of aspirin or clopidogrel bisulfate plus a statin in unitized dosages a range of 10 mg to 80 mg, a diuretic in unitized dosages in a range of 25 mg to 80 mg, and an ace inhibitor in unitized dosages in a range of 10 mg to 40 mg;

a second plurality of one-a-day pills with a therapeutically effective amount of aspirin or clopidogrel bisulfate plus a statin in unitized dosages in a range of 10 mg to 20 mg, a diuretic in unitized dosages in a range of 25 mg to 50 mg, an ace inhibitor in unitized dosages in a range of 10 mg to 40 mg and a fenofibrate in unitized dosages in a range of about 67 mg to 200 mg;

a third plurality of one-a-day pills with a therapeutically effective amount of aspirin or clopidogrel bisulfate plus a statin in unitized dosages in a range of 10 mg to 80 mg, an ace inhibitor in unitized dosages in a range of 10 mg to 40 mg and a fenofibrate in unitized dosages in a range of about 67 mg to 200 mg;

a fourth plurality one-a-day pills with a therapeutically effective amount of aspirin or clopidogrel bisulfate plus a diuretic in unitized dosages in a range of 25 mg to 80 mg, and an ace inhibitor in unitized dosages in a range of 10 mg to 40 mg;

a fifth plurality of one-a-day pills with a therapeutically effective amount of aspirin or clopidogrel bisulfate plus a diuretic in unitized dosages in a range of 25 mg to 80 mg, an ace inhibitor in unitized dosages in a range of 10 mg to 40 mg and a fenofibrate in unitized dosages in a range of about 160 mg to 200 mg;

a sixth plurality of one-a-day pills with a therapeutically effective amount of aspirin or clopidogrel bisulfate plus an ace inhibitor in unitized dosages in a range of 10 mg to 40 mg and a fenofibrate in unitized dosages in a range of about 160 mg to 200 mg;

a seventh plurality of one-a-day pills with a therapeutically effective amount of aspirin or clopidogrel bisulfate plus a statin in unitized dosages in a range of 10 mg to 80 mg, and an ace inhibitor in unitized dosages in a range of 10 mg to 40 mg;

an eighth plurality of one-a-day pills with a therapeutically effective amount of aspirin or clopidogrel bisulfate plus a statin in unitized dosages in a range of 10 mg to 80 mg and a diuretic in unitized dosages in a range of 25 mg to 80 mg;

a ninth plurality of one-a-day pills with a therapeutically effective amount of aspirin or clopidogrel bisulfate plus a statin in unitized dosages in a range of 10 mg to 80 mg, and a fenofibrate in unitized dosages in a range of about 67 mg to 200 mg;

a tenth plurality of one-a-day pills with a therapeutically effective amount of aspirin or clopidogrel bisulfate plus a statin in unitized dosages in a range of 10 mg to 80 mg, a diuretic in unitized dosages in a range of 25 mg to 80 mg, and a fenofibrate in unitized dosages in a range of about 67 mg to 200 mg;

an eleventh plurality of one-a-day pills with a therapeutically effective amount of aspirin or clopidogrel bisulfate plus a diuretic in unitized dosages in a range of 25 mg to 50 mg and a fenofibrate in unitized dosages in a range of about 67 mg to 200 mg;

wherein said statins are unitized in 10, 20, 40 and 80 mg dosages;

said diuretic is unitized in 25, 50 and 80 mg dosages;

said ace inhibitor is unitized in 10, 20 and 40 mg dosages; and

said fenofibrate is unitized in about 67, 160 and 200 mg dosages.