NMR device for detection of analytes
First Claim
Patent Images
1. A device for detection of an analyte, the device comprising:
- a support defining a well for holding a liquid sample comprising magnetic particles and said analyte, said magnetic particles having binding moieties linked thereto; and
an RF coil disposed about said liquid sample, said RF coil configured to detect an echo response produced by exposing said liquid sample to a bias magnetic field created using one or more magnets and an RF excitation, wherein said RF coil has a characteristic dimension from about 10 μ
m to about 1000 μ
m.
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Abstract
This invention relates generally to detection devices having one or more small wells each surrounded by, or in close proximity to, an NMR micro coil, each well containing a liquid sample with magnetic nanoparticles that self-assemble or disperse in the presence of a target analyte, thereby altering the measured NMR properties of the liquid sample. The device may be used, for example, as a portable unit for point of care diagnosis and/or field use, or the device may be implanted for continuous or intermittent monitoring of one or more biological species of interest in a patient.
135 Citations
106 Claims
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1. A device for detection of an analyte, the device comprising:
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a support defining a well for holding a liquid sample comprising magnetic particles and said analyte, said magnetic particles having binding moieties linked thereto; and
an RF coil disposed about said liquid sample, said RF coil configured to detect an echo response produced by exposing said liquid sample to a bias magnetic field created using one or more magnets and an RF excitation, wherein said RF coil has a characteristic dimension from about 10 μ
m to about 1000 μ
m. - View Dependent Claims (2, 5, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 20, 21, 22, 23, 31, 33, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 98, 101, 102, 103, 106)
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3-4. -4. (canceled)
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6. (canceled)
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18-19. -19. (canceled)
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24-30. -30. (canceled)
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32. (canceled)
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34-36. -36. (canceled)
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47. A device for detection of an analyte, said device comprising a plurality of wells for holding a liquid sample comprising magnetic particles and said analyte, said magnetic particles having binding moieties linked thereto, and, for each of said wells:
an RF coil disposed about said well, said RF coil configured to detect an echo response produced by exposing said liquid sample in said well to a bias magnetic field created using one or more magnets and an RF excitation. - View Dependent Claims (48, 53, 54, 55, 56, 57, 58, 59, 60, 61, 63, 64, 66, 67, 68, 69, 70, 71)
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49-52. -52. (canceled)
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62. (canceled)
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65. (canceled)
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72. A device comprising:
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a support defining one or more wells for holding a liquid sample; and
disposed on said support, for reconstitution within said one or more wells, dried superparamagnetic particles having binding moieties linked thereto, wherein said binding moieties are operative to alter an aggregation of said magnetic particles in said liquid sample as a function of the presence or concentration of an analyte in said liquid sample. - View Dependent Claims (73)
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74-97. -97. (canceled)
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99-100. -100. (canceled)
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104-105. -105. (canceled)
Specification