Aqueous suspensions of ciclesonide for nebulisation
First Claim
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1. A method for preparing a sterile aqueous suspension of ciclesonide suitable for nebulization comprising the steps of:
- a. providing an aqueous suspension of ciclesonide, containing one or more pharmaceutically acceptable excipients, which one or more excipients are all non-ionic excipients; and
b. autoclaving the aqueous suspension provided in (a).
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Abstract
This invention relates to a method for the preparation of sterile aqueous suspensions of ciclesonide by sterilization with moist heat. The invention further relates to pharmaceutical compositions in particular to sterile aqueous suspensions of ciclesonide for administration by nebulization in the prophylaxis and/or treatment of respiratory diseases.
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Citations
41 Claims
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1. A method for preparing a sterile aqueous suspension of ciclesonide suitable for nebulization comprising the steps of:
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a. providing an aqueous suspension of ciclesonide, containing one or more pharmaceutically acceptable excipients, which one or more excipients are all non-ionic excipients; and
b. autoclaving the aqueous suspension provided in (a). - View Dependent Claims (3, 4, 5, 6, 9, 12, 13, 14, 15, 17, 18, 19, 20)
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2. A method for preparing a sterile aqueous suspension of ciclesonide suitable for nebulization comprising the steps of:
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a. providing an aqueous suspension of ciclesonide, containing at least one non-ionic agent for adjusting osmolality and optionally further pharmaceutically acceptable excipients; and
b. autoclaving the aqueous suspension provided in (a). - View Dependent Claims (7, 8, 10, 11, 16)
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- 21. A sterile aqueous suspension of ciclesonide suitable for nebulization containing one or more pharmaceutically acceptable excipients, which one or more excipients are all non-ionic excipients.
- 22. A sterile aqueous suspension of ciclesonide suitable for nebulization containing at least one non-ionic agent for adjusting osmolality and optionally further pharmaceutically acceptable excipients.
- 33. An aqueous suspension of ciclesonide for administration by nebulization, wherein the concentration of ciclesonide within the suspension for nebulization is in the range of 0.005% to 0.5% (w/v).
Specification