Method for evaluating extracellular water concentration in tissue
First Claim
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1. A method for assessing an extracellular water metric in a subject, said method comprising:
- emitting light of at least one wavelength toward a tissue site of interest, wherein a portion of the emitted light is reflected by the tissue site of interest;
detecting at least one wavelength of the light reflected by the tissue site of interest from a position about one millimeter to about five millimeters from the tissue site of interest;
emitting light of at least one wavelength toward a reference tissue site, wherein a portion of the emitted light is reflected by the reference tissue site;
detecting at least one wavelength of the light reflected by the reference tissue site from a position about one millimeter to about five millimeters from the reference tissue site; and
processing detected reflected light from the tissue site of interest and detected reflected light from the reference tissue site to compute the extracellular water metric.
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Abstract
The present disclosure provides systems, devices, and/or methods for assessing body fluid-related metrics and/or changes therein. The disclosure further provides systems, devices, and/or methods for correlating body fluid-related metrics in a particular tissue with the corresponding whole-body metric. The disclosure also provides, systems, devices, and/or methods for assessment of such metrics to facilitate diagnosis and/or therapeutic interventions related to maintaining and/or restoring body fluid balance.
152 Citations
66 Claims
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1. A method for assessing an extracellular water metric in a subject, said method comprising:
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emitting light of at least one wavelength toward a tissue site of interest, wherein a portion of the emitted light is reflected by the tissue site of interest;
detecting at least one wavelength of the light reflected by the tissue site of interest from a position about one millimeter to about five millimeters from the tissue site of interest;
emitting light of at least one wavelength toward a reference tissue site, wherein a portion of the emitted light is reflected by the reference tissue site;
detecting at least one wavelength of the light reflected by the reference tissue site from a position about one millimeter to about five millimeters from the reference tissue site; and
processing detected reflected light from the tissue site of interest and detected reflected light from the reference tissue site to compute the extracellular water metric. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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31. A method for assessing a whole-body extracellular water metric in a subject, said method comprising:
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assessing a first localized extracellular water metric at a first tissue site in the subject;
assessing a second localized extracellular water metric at a second tissue site in the subject; and
processing the first and second localized extracellular water metrics to produce a whole-body extracellular water metric. - View Dependent Claims (32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 49)
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46. A method for assessing changes in extracellular fluid volume, said method comprising:
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measuring a first optical signal received by an optical detector at a tissue site having a first hydrostatic pressure;
measuring a second optical signal received by an optical detector at a tissue site having a second hydrostatic pressure;
estimating fluid content from the first and second sets of optical signals; and
determining the relationship of said fluid-content estimates to the differences in hydrostatic pressure and estimating changes in extracellular fluid volume from said relationship. - View Dependent Claims (47, 48, 50, 51, 52, 53, 54, 55, 56)
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57. A system for assessing a whole body fluid metric in a subject, said system comprising:
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a local fluid content probe configured to assess a local fluid metric at a tissue site of interest;
a local fluid content probe configured to assess a local fluid metric at a tissue reference site; and
a processing device, wherein the processing device is operably coupled to the local fluid content probe configured to assess a local fluid metric at a tissue site of interest, operably coupled to the local fluid content probe configured to assess a local fluid metric at a tissue reference site, and configured to process a local fluid content metric at a tissue site of interest and a local fluid content metric at a tissue reference site to produce a whole-body fluid content metric. - View Dependent Claims (58, 59, 60, 61)
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62. A system for assessing an extracellular fluid metric in a subject, said system comprising:
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a local fluid content probe configured to assess a local fluid content metric at a tissue site;
a location information sensor configured to assess location information of the probe, the tissue site of interest, or the probe and the tissue site of interest; and
a processor, wherein the processor is operably coupled to the local fluid content probe, operably coupled to the location information processor, and configured to process a local fluid content metric and location information to produce an extracellular fluid metric.
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63. A probe for assessing a body fluid metric, said probe comprising:
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a probe housing configured to be placed proximal to a tissue site of interest and having at least one sanitized surface;
a near infrared light emission fiber optic cable connected to the probe housing and configured to conduct radiation of at least one wavelength to the tissue location;
a near infrared light detection fiber optic cable connected to the probe housing and configured to receive at least one wavelength of radiation from the tissue location; and
a tissue compressor configured to alter the hydrostatic pressure of a tissue site of interest, alter the hydrostatic pressure of a tissue reference site, or alter the hydrostatic pressure of both a tissue site of interest and a tissue reference site. - View Dependent Claims (64, 65)
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66. A system for assessing an extracellular fluid content metric, said system comprising:
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a means for assessing a fluid content metric at a tissue site at a first hydrostatic pressure;
a means for assessing a fluid content metric at a tissue site at a second hydrostatic pressure; and
a means for processing the fluid content metric at the tissue site at the first hydrostatic pressure and the fluid content metric at the tissue site at the second hydrostatic pressure to produce an extracellular fluid content metric.
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Specification