Iontophoresis challenge for monitoring cardiovascular status
First Claim
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1. A method of assessing vascular and/or neurovascular responsiveness in an individual comprising:
- continuously measuring and recording skin temperature at a test location on an individual;
administering a vasostimulator compound by iontophoresis to the test location; and
determining vascular and/or neurovascular responsiveness on the basis of skin temperature changes in response to the vasoactive compound.
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Abstract
Methods and apparatus are provided for determining individual vascular responses by employing iontophoresis to deliver vasoactive compounds to local area and determining resultant changes in blood flow by measuring changes in skin temperature as a correlate of local blood flow. The invention further provides methods and apparatus for assessing vascular reactivity in individuals under ambulatory conditions and relating stress responses to vascular reactivity.
58 Citations
21 Claims
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1. A method of assessing vascular and/or neurovascular responsiveness in an individual comprising:
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continuously measuring and recording skin temperature at a test location on an individual;
administering a vasostimulator compound by iontophoresis to the test location; and
determining vascular and/or neurovascular responsiveness on the basis of skin temperature changes in response to the vasoactive compound. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A vascular and/or neurovascular function measurement device comprising:
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a housing including an iontophoretic chamber adapted to store and deliver a charged vasostimulator e compound through skin of a patient; and
one or more temperature sensors mounted on the housing and adapted to detect changes in skin temperature in response to delivery of the vasostimulator compound. - View Dependent Claims (13, 14, 15, 16, 17)
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18. A method of vascular and/or neurovascular function measurement comprising:
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initiating monitoring of an inherent temperature of a mucosal surface;
administering a vasostimulator directly to the mucosal surface;
continuing to monitor any temperature change as a consequence of administration of the vasostimulator; and
determining vascular and/or neurovascular responsiveness on the basis of temperature changes in response to the vasostimulator. - View Dependent Claims (19, 20, 21)
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Specification