Bioartificial guidance conduit and method for forming the same
First Claim
1. A bioartificial guidance conduit formed by coaxially stacking a plurality of discs, wherein each disc contains at least one penetrating hole, and at least one said penetrating hole on adjacent said plurality of discs connects with each other while said plurality of discs coaxially stacked, so as to run through the formed bioartificial guidance conduit.
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Accused Products
Abstract
The present invention discloses a bioartificial guidance conduit formed by coaxially stacking a plurality of discs and the method for forming the same, wherein each disc contains at least one penetrating hole, and at least one penetrating hole on adjacent discs connects with each other while discs coaxially stacked, so as to run through the formed bioartificial guidance conduit.
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Citations
56 Claims
- 1. A bioartificial guidance conduit formed by coaxially stacking a plurality of discs, wherein each disc contains at least one penetrating hole, and at least one said penetrating hole on adjacent said plurality of discs connects with each other while said plurality of discs coaxially stacked, so as to run through the formed bioartificial guidance conduit.
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12. A method for forming a bioartificial guidance conduit, comprising:
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providing a substrate with a photoresist layer;
performing a lithographic process on said photoresist layer to form a mold that comprises at least one first pattern having a flat-bottom cave and at least one second pattern having a plurality of pillar-shaped structures extending from said flat-bottom cave, wherein the depth of said flat-bottom cave is substantially equal to the height of said pillar-shaped structure;
performing a mold-filling process to fill said mold with a biocompatible material, so as to form at least one disc, wherein the main body of said disc is formed by said first pattern, and at least one penetrating hole of said disc is formed by said second pattern;
performing a mold-releasing process to take out at least one said disc;
repeating said mold-filling process and said mold-releasing process to produce a plurality of said discs; and
performing a coaxially stacking process to stack said plurality of discs, and said bioartificial guidance conduit is then formed, wherein at least one said penetrating hole on adjacent said plurality of discs connects with each other, so as to run through said bioartificial guidance conduit. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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26. A method for forming a bioartificial guidance conduit, comprising:
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providing a substrate with a photoresist layer;
performing a lithographic process on said photoresist layer to form a first mold that comprises at least one first pattern having a flat-bottom cave and at least one second pattern having a plurality of pillar-shaped structures extending from said flat-bottom cave, the depth of said flat-bottom cave is substantially equal to the height of said pillar-shaped structure;
performing a first remolding process by said first mold and a first flexible material to fabricate a second mold;
performing a second remolding process by said second mold and a second flexible material to fabricate a third mold, wherein said third mold comprises substantially the same said first pattern and said second pattern;
performing a mold-filling process to fill said third mold with a biocompatible material, so as to form at least one disc, wherein the main body of said disc is formed by said first pattern, and at least one penetrating hole of said disc is formed by said second pattern;
performing a mold-releasing process to take out at least one said disc;
repeating said mold-filling process and said mold-releasing process to produce a plurality of said discs; and
performing a coaxially stacking process to stack said plurality of discs, so as to form said bioartificial guidance conduit, wherein at least one said penetrating hole on adjacent said plurality of discs connects with each other, so as to run through said bioartificial guidance conduit. - View Dependent Claims (27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42)
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43. A method for forming a bioartificial guidance conduit, comprising:
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providing a substrate with a photoresist layer;
performing a lithographic process on said photoresist layer to form a first mold that comprises at least one first pattern having a raised flat-top structure and at least one second pattern having a plurality of tubular holes extending into said substrate from said raised flat-top structure, wherein the height of said raised flat-top structure is substantially equal to the depth of said tubular hole;
performing a remolding process by said first mold and a flexible material to fabricate a second mold, wherein said second mold comprises a third pattern complementary to said first pattern and a fourth pattern complementary to said second pattern, and the height of said third pattern is substantially equal to the height of said fourth pattern;
performing a mold-filling process to fill said second mold with a biocompatible material, so as to form at least one disc, wherein the main body of said disc is formed by said third pattern, and at least one penetrating hole of said disc is formed by said fourth pattern;
performing a mold-releasing process to take out at least one said disc;
repeating said mold-filling process and said mold-releasing process to produce a plurality of said discs; and
performing a coaxially stacking process to stack said plurality of discs, so as to form said bioartificial guidance conduit, wherein at least one said penetrating hole on adjacent said plurality of discs connects with each other, so as to run through said bioartificial guidance conduit. - View Dependent Claims (44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56)
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Specification