Compositions and methods to create a vascularized environment for cellular transplantation
First Claim
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1. A biocompatible implant, comprising a support and at least one pharmaceutical agent that increases cellular HIF-1α
- protein levels.
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Abstract
The present invention generally relates to biocompatible devices suitable for increasing cellular HIF-1 α protein levels. In particular, the present invention relates to an implant comprising a biocompatible support loaded with at least one pharmaceutical agent capable of increasing cellular HIF-1 α protein levels to promote vascularization at or near the implant site. Vascularization of the implanted support results in enhanced survival of cells optionally incorporated within the support. Methods for treating a disease or injury via implanting the support of the present invention are also provided.
38 Citations
54 Claims
- 1. A biocompatible implant, comprising a support and at least one pharmaceutical agent that increases cellular HIF-1α
- 3. A biocompatible implant, comprising a support and at least one pharmaceutical agent that inhibits the degradation of HIF-1α
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17. A method of making a biocompatible implant to increase cellular HIF-1α
- levels, comprising the steps of;
a. incorporating at least one pharmaceutical agent capable of increasing cellular HIF-1α
protein levels into a support;
b. isolating and preparing mammalian tissue, and c. introducing the mammalian tissue into the support. - View Dependent Claims (18)
- levels, comprising the steps of;
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19. A method of making a biocompatible implant to decrease the degradation of HIF-1α
- protein, comprising the steps of;
a. incorporating at least one pharmaceutical agent capable of decreasing the degradation of HIF-1α
protein into a support;
b. isolating and preparing mammalian tissue, and c. introducing the mammalian tissue into the support. - View Dependent Claims (20)
- protein, comprising the steps of;
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21. A method of promoting vascularization in a patient, comprising the steps of:
-
a. incorporating at least one pharmaceutical agent capable of increasing cellular HIF-1α
protein levels, andb. isolating and preparing mammalian tissue for introduction to the support, and c. introducing the mammalian tissue into the support, and d. implanting the support containing mammalian tissue into a site within a patient. - View Dependent Claims (22, 23)
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24. A method of promoting vascularization in a patient, comprising the steps of:
-
a. incorporating at least one pharmaceutical agent capable of decreasing the degradation of HIF-1α
protein, andb. isolating and preparing mammalian tissue for introduction to the support, and c. introducing the mammalian tissue into the support, and d. implanting the support containing mammalian tissue into a site within a patient. - View Dependent Claims (25, 26)
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27. A method of promoting vascularization in a patient, comprising the steps of:
-
a. incorporating at least one pharmaceutical agent capable of increasing cellular HIF-1α
protein levels, andb. implanting the support into a site within a patient. - View Dependent Claims (28, 29)
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30. A method of promoting vascularization in a patient, comprising the steps of:
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a. incorporating at least one pharmaceutical agent capable of decreasing the degradation of HIF-1α
protein, andb. implanting the support into a site within a patient. - View Dependent Claims (31, 32)
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Specification