Coatings on ophthalmic lenses
First Claim
1. A method of forming a surface modified medical device, the method comprising:
- providing a medical device made of a copolymer that is the polymerization product of a monomer mixture comprising a monomer that has at least one group providing surface functionality to at least one surface of the medical device;
providing a surface modifying agent comprising a terminal functionalized surfactant having functionalized reactivity that is complimentary to the at least one group providing surface functionality of the medical device;
contacting the at least one surface having reactive functionality of the medical device with the surface modifying agent, and;
subjecting the device surface and surface modifying agent to reaction conditions suitable for forming a covalent bond between the device surface and the surface modifying agent to form a surface modified medical device.
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Accused Products
Abstract
This invention is directed toward surface treatment of a device. The surface treatment comprises the attachment of terminal functionalized surfactants to the surface of the substrate by means of reactive functionalities of the terminal functionalized surfactant material reacting with complementary surface reactive functionalities in monomeric units along the polymer substrate. The present invention is also directed to a surface modified medical device, examples of which include contact lenses, intraocular lenses, vascular stents, phakic intraocular lenses, aphakic intraocular lenses, corneal implants, catheters, implants, and the like, comprising a surface made by such a method.
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Citations
54 Claims
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1. A method of forming a surface modified medical device, the method comprising:
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providing a medical device made of a copolymer that is the polymerization product of a monomer mixture comprising a monomer that has at least one group providing surface functionality to at least one surface of the medical device;
providing a surface modifying agent comprising a terminal functionalized surfactant having functionalized reactivity that is complimentary to the at least one group providing surface functionality of the medical device;
contacting the at least one surface having reactive functionality of the medical device with the surface modifying agent, and;
subjecting the device surface and surface modifying agent to reaction conditions suitable for forming a covalent bond between the device surface and the surface modifying agent to form a surface modified medical device. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 42, 43, 44, 48, 49, 52, 53, 54)
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21. A method of forming a surface modified medical device, the method comprising:
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providing a medical device made of a copolymer that is the polymerization product of a monomer mixture wherein the polymerized monomer mixture does not contain a surface functionality;
providing a surface functionality to at least one surface of the medical device;
providing a surface modifying agent comprising a terminal functionalized surfactant having functionalized reactivity that is complimentary to the at least one group providing surface functionality of the medical device;
contacting the at least one surface having reactive functionality of the medical device with the surface modifying agent, and;
subjecting the device surface and surface modifying agent to reaction conditions suitable for forming a covalent bond between the device surface and the surface modifying agent to form a surface modified medical device. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 45, 46, 47, 50)
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38. A surface modified medical device comprising:
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a medical device manufactured from a monomer mixture conprising surface functionality after polymerization of the monomer mixture; and
one or more reactive terminal functionalized surfactants applied to the surface of the medical device;
whereby a chemical reaction between the surface functionality of the medical device and the one or more reactive terminal functionalized surfactants forms covalent bonds there between. - View Dependent Claims (39, 40, 41, 51)
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Specification