DEVICES AND METHODS FOR PHARMACOKINETIC-BASED CELL CULTURE SYSTEM
First Claim
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1. A method for producing a biological product comprising:
- providing a culture device that contains a culture medium, and a cell that generates a biological product wherein the culture device maintains the cell within a first microscale chamber under conditions that provide a value of at least one pharmacokinetic parameter in vitro that is comparable to a value of at least one pharmacokinetic parameter obtained in vivo, and wherein the first microscale chamber comprises a first inlet and a first outlet for flow of the culture medium.
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Abstract
Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device.
50 Citations
22 Claims
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1. A method for producing a biological product comprising:
providing a culture device that contains a culture medium, and a cell that generates a biological product wherein the culture device maintains the cell within a first microscale chamber under conditions that provide a value of at least one pharmacokinetic parameter in vitro that is comparable to a value of at least one pharmacokinetic parameter obtained in vivo, and wherein the first microscale chamber comprises a first inlet and a first outlet for flow of the culture medium. - View Dependent Claims (2, 3, 4, 5)
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6. A culture device comprising:
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a biological material that generates a biological product;
a fluid; and
at least one microscale feature that is configured to maintain the biological material under conditions that provide a value of at least one pharmacokinetic parameter in vitro that is comparable to a value of at least one pharmacokinetic parameter obtained in vivo. - View Dependent Claims (7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A method for producing a biological product comprising providing a culture device with a biological material that generates a biological product and a culture medium with a first microscale feature that is configured to maintain the biological product under conditions that provide a value of at least one pharmacokinetic parameter in vitro that is comparable to a value of at least one pharmacokinetic parameter obtained in vivo.
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21. A device for producing a biological product comprising means for providing a culture device with a biological material that generates a biological product and a culture medium wherein the means maintains the biological material within a first microscale feature under conditions that provide a value of at least one pharmacokinetic parameter in vitro that is comparable to a value of at least one pharmacokinetic parameter obtained in vivo.
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22. A culture device comprising:
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a biological material that generates a biological product;
a fluid; and
a microscale chamber for maintaining the biological material comprising a geometry simulating parts of a living body, wherein the microscale chamber is configured to substantially mimic at least one measurable condition in vivo.
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Specification