Novel chemical entities affecting neuroblastoma tumor-initiating cells
First Claim
1. A neuroblastoma inhibiting composition comprising a chemical entity that selectively affects neuroblastoma tumor-initiating cells, said composition comprising one or more active ingredients comprising:
- 2.3-Dimethoxy-1.4-naphthoquinone, Aklavine Hydrochloride, Amodiaquin dihydrochloride dehydrate;
Amsacrine Hydrochloride;
Azaguanine-8;
beta-peltatin;
Camptothecine (S.+);
CGP-74514A hydrochloride;
Chelerythrine chloride;
Cholestan-3beta.5alpha.6beta-Triol;
Ciclopirox Olamine;
Clofazimine;
Colchicine;
Convallatoxin;
Crassin Acetate;
Crinamine;
Dequalinium analog. C-14 linker;
Dequalinium dichloride;
Digitoxin;
Digoxigenin;
Dihydrogambogic acid;
Dihydroouabain;
Erysolin;
Gambogic acid;
Mechlorethamine;
Meclizine hydrochloride;
MG 624;
Mitoxanthrone Hydrochloride;
Ouabain;
Oxybendazole;
Oxybendazole;
Paclitaxel;
Parthenolide;
Patulin;
Periplocymarin;
Peruvoside;
Primaquine diphosphate;
Quinacrine dihydrochloride;
Sanguinarine chloride;
or Tomatine.
1 Assignment
0 Petitions
Accused Products
Abstract
Disclosed are neuroblastoma tumor-initiating cell inhibiting compositions comprising chemical entities capable of affecting neuroblastoma tumor-initiating cells. Pharmaceutical preparations that include these chemical entities are also provided for the treatment of neuroblastoma. These pharmaceutical preparations are suitable for the treatment of humans, and are particularly suited for the treatment of children of 12 years of age or younger having neuroblastoma. The compositions and pharmaceutical preparations posses reduced normal cell cytotoxicity. The compositions and pharmaceutical preparations may be used alone or together with other conventional neuroblastoma preparations as part of a clinical regimen in the treatment and management of neuroblastoma.
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Citations
20 Claims
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1. A neuroblastoma inhibiting composition comprising a chemical entity that selectively affects neuroblastoma tumor-initiating cells, said composition comprising one or more active ingredients comprising:
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2.3-Dimethoxy-1.4-naphthoquinone, Aklavine Hydrochloride, Amodiaquin dihydrochloride dehydrate;
Amsacrine Hydrochloride;
Azaguanine-8;
beta-peltatin;
Camptothecine (S.+);
CGP-74514A hydrochloride;
Chelerythrine chloride;
Cholestan-3beta.5alpha.6beta-Triol;
Ciclopirox Olamine;
Clofazimine;
Colchicine;
Convallatoxin;
Crassin Acetate;
Crinamine;
Dequalinium analog. C-14 linker;
Dequalinium dichloride;
Digitoxin;
Digoxigenin;
Dihydrogambogic acid;
Dihydroouabain;
Erysolin;
Gambogic acid;
Mechlorethamine;
Meclizine hydrochloride;
MG 624;
Mitoxanthrone Hydrochloride;
Ouabain;
Oxybendazole;
Oxybendazole;
Paclitaxel;
Parthenolide;
Patulin;
Periplocymarin;
Peruvoside;
Primaquine diphosphate;
Quinacrine dihydrochloride;
Sanguinarine chloride;
orTomatine. - View Dependent Claims (2, 3, 4)
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5. A pharmaceutical formulation for the inhibition of neuroblastoma comprising an effective amount of a neuroblastoma tumor-initiating cell inhibiting composition, said composition comprising one or more active ingredients comprising:
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2.3-Dimethoxy-1.4-naphthoquinone, Aklavine Hydrochloride, Amodiaquin dihydrochloride dehydrate;
Amsacrine Hydrochloride;
Azaguanine-8;
beta-peltatin;
Camptothecine (S.+);
CGP-74514A hydrochloride;
Chelerythrine chloride;
Cholestan-3beta.5alpha.6beta-Triol;
Ciclopirox Olamine;
Clofazimine;
Colchicine;
Convallatoxin;
Crassin Acetate;
Crinamine;
Dequalinium analog. C-14 linker;
Dequalinium dichloride;
Digitoxin;
Digoxigenin;
Dihydrogambogic acid;
Dihydroouabain;
Erysolin;
Gambogic acid;
Mechlorethamine;
Meclizine hydrochloride;
MG 624;
Mitoxanthrone Hydrochloride;
Ouabain;
Oxybendazole;
Oxybendazole;
Paclitaxel;
Parthenolide;
Patulin;
Periplocymarin;
Peruvoside;
Primaquine diphosphate;
Quinacrine dihydrochloride;
Sanguinarine chloride;
orTomatine. - View Dependent Claims (6, 7)
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- 8. A method for inhibiting neuroblastoma tumor-initiating cells comprising administering an effective amount of a composition comprising a neuroblastoma tumor-initiating cell inhibiting ingredient.
- 15. A method for inhibiting neuroblastoma in an animal comprising administering an effective amount of a composition comprising a neuroblastoma tumor-initiating cell inhibiting ingredient.
Specification