×

PAR2-modulating compounds and their use

  • US 20070123508A1
  • Filed: 05/16/2006
  • Published: 05/31/2007
  • Est. Priority Date: 05/27/2005
  • Status: Abandoned Application
First Claim
Patent Images

1. A compound having the chemical structure embedded image or a pharmaceutically acceptable salt or prodrug thereof, wherein:

  • n is 1, 2, or 3;

    R1 is selected from the group consisting of hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroalicyclyl, —

    CN, —

    C(═

    Z)R4, —

    C(═

    Z)OR4, —

    C(═

    Z)NR4R4a, —

    N(R4)—

    C(═

    Z)R4a, —

    N(R4)—

    C(═

    Z)NR4bR4a, —

    OC(═

    Z)R4, and —

    SR4;

    R1a is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, aryl, halogen, hydroxyl, nitro, amino, sulfonyl, perhaloalkyl, —

    OR4, —

    NR4R4a, —

    CN, —

    C(═

    Z)R4, —

    C(═

    Z)OR4, —

    C(═

    Z)NR4R4a;

    R2 is selected from the group consisting of hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkenyl, substituted or unsubstituted aryl and unsubstituted or substituted heteroaryl; and

    , R3 is selected from the group consisting of hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroalicyclyl, hydroxy, perhaloalkyl, —

    OR4, —

    NR4R4a, —

    NR4NR4aR4b, —

    NR4N═

    CR4aR4b, —

    N(R4)C(R4a)═

    NR4b, —

    N(R4)—

    C(═

    Z)R4a, —

    N(R4)—

    C(═

    Z)NR4bR4a, and —

    SR4, wherein;

    Z is oxygen or sulfur; and

    , R4, R4a and R4b are independently selected from the group consisting of;

    hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroalicyclyl.

View all claims
  • 1 Assignment
Timeline View
Assignment View
    ×
    ×