Polymer derivatives
First Claim
1. A water-soluble compound comprising a polymer and at least one terminal azide moiety, wherein said polymer is selected from the group consisting of poly(alkylene oxides), poly(oxyethylated polyols), and poly(olefinic alcohols).
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Abstract
The invention provides water-soluble compounds that include a polymer and at least one terminal azide or acetylene moiety. Also provided are highly efficient methods for the selective modification of proteins with PEG derivatives, which involves the selective incorporation of non-genetically encoded amino acids, e.g., those amino acids containing an azide or acetylene moiety, into proteins in response to a selector codon and the subsequent modification of those amino acids with a suitably reactive PEG derivative.
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Citations
74 Claims
- 1. A water-soluble compound comprising a polymer and at least one terminal azide moiety, wherein said polymer is selected from the group consisting of poly(alkylene oxides), poly(oxyethylated polyols), and poly(olefinic alcohols).
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24. A water soluble activated polymer that is stable against hydrolysis, said activated polymer having the formula:
R—
CH2CH2—
(OCH2 CH2)n—
N3;
whereinn is from about 5 to 3,000, and R is a capping group, a functional group, or a leaving group that can be the same or different from the azide. - View Dependent Claims (25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36)
- 37. A water-soluble compound comprising a polymer and at least one acetylene moiety, wherein said polymer is selected from the group consisting of poly(alkylene oxides), poly(oxyethylated polyols), and poly(olefinic alcohols).
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62. A water soluble activated polymer that is stable against hydrolysis, said activated polymer having the formula:
R—
CH2CH2—
(OCH2CH2)n—
C≡
CHwherein n is from about 5 to 3,000, and R is a capping group, a functional group, or a leaving group that can be the same or different from the azide. - View Dependent Claims (63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74)
Specification