Ophthalmic instruments, systems and methods especially adapted for conducting simultaneous tonometry and pachymetry measurements

• US 20070123768A1
• Filed: 11/30/2005
• Published: 05/31/2007
• Est. Priority Date: 11/30/2005
• Status: Abandoned Application

• Current Assignee: Duke University
• Original Assignee: Duke University
• Inventors: Challa, Pratap, Toth, Cynthia, Izatt, Joseph, Herndon, Leon, Freedman, Sharon, Applegate, Brian, Overaker, Ronald, McKinley, Phillip, Dodge, Brian
• Application Number:
  US11/289,639
• Publication Number:
  US 20070123768A1
• Time in Patent Office: Days
• US Class Current: 600/405
• CPC Class Codes: A61B 3/1005 for measuring distances inside the eye, e.g. thickness of the cornea A61B3/11 takes precedence
• CPC Class Codes: A61B 3/16 for measuring intraocular pressure, e.g. tonometers

Abstract

Ophthalmic instruments, systems and methods enable tonometry and pachymetry measurements to be conducted simultaneously. As such, a patient'"'"'s intraocular pressure (IOP) corrected for corneal thickness may be determined accurately by a single corneal applanation. Preferably, the ophthalmic instruments have a reference surface at a distal end of the instrument, an applanation plate spaced from the reference surface, and a compliant mount for mounting the applanation plate for resilient displacements relative to the reference surface. The instrument most preferably has a housing such that the reference surface is located at a fixed position at one end of the housing, and the applanation plate is mounted to that one end of the housing in coaxial spaced alignment relative to the reference surface by means of the compliant mount. If desired, the housing may have a handle and a substantially orthogonal head piece containing suitable optic mirrors which allow visible light to pass therethrough so that the procedure can be viewed and/or photographed.

Claims

1. An ophthalmic instrument comprising:

instrument means for determining simultaneously an intraocular pressure measurement in response to corneal applanation, and a corneal thickness measurement in response to corneal reflection of light during corneal applanation; and

signal generating means for generating signals indicative of the simultaneously determined intraocular pressure and corneal thickness measurements.

2. An ophthalmic instrument as in claim 1, wherein the instrument means comprises an applanation tonometer having an applanation tip defining an application surface, a slit lamp tonometer operatively connected to the applanation tip, and a pressure sensor operatively connected to the slit lamp tonometer for outputting the signal indicative of intraocular pressure measurement.

3. An ophthalmic instrument as in claim 2, wherein the instrument means comprises a pachymeter having an optical fiber with a terminal end which is coaxially embedded within the applanation tip so as to be coplanar with the applanation surface, and an interferometer operatively connected to the optical fiber for receiving corneal reflection of light and outputting the signal indicative of corneal thickness measurement based thereon.

4. An ophthalmic instrument as in claim 1, wherein the instrument means comprises:

an applanation surface for contact with a cornea; and

an interferometer system for determining simultaneously intraocular pressure and corneal thickness conditions in response to optical signals propagating along a common optical signal path between the applanation surface and the interferometer.

5. An ophthalmic instrument as in claim 1, wherein the instrument means comprises:

an applanation tonometer for determining an intraocular pressure measurement; and

an optical pachymeter for determining a corneal thickness measurement;

wherein

the tonometer and optical pachymeter are integral so as to simultaneously generate respective output signals indicative of the intraocular pressure and corneal thickness measurements in response to a single corneal applanation.

6. An ophthalmic instrument as in claim 1, wherein the instrument means comprises:

(i) a reference surface;

(ii) an applanation plate spaced from the reference surface; and

(iii) a compliant mount for mounting the applanation plate for resilient displacements relative to the reference surface.

7. An ophthalmic instrument comprising:

(i) a reference surface at a distal end of the instrument;

(ii) an applanation plate spaced from the reference surface; and

(iii) a compliant mount for mounting the applanation plate for resilient displacements relative to the reference surface.

8. The instrument of claim 7, further comprising a housing, wherein

the reference surface is located at a fixed position at one end of the housing, and wherein

the applanation plate is mounted to the one end of the housing in coaxial spaced alignment relative to the reference surface by the compliant mount

9. The instrument of claim 8, further comprising an optical connector at another end of the housing for receiving an optical signal guide.

10. The instrument of claim 8, wherein the housing comprises a handle and a headpiece connected to the handle, wherein the reference surface is located at a fixed position at a distal end of the headpiece.

11. The instrument of claim 10, further comprising an optical connector at a lower end of the handle.

12. The instrument of claim 10, wherein the headpiece comprises a proximal end for viewing, and wherein the instrument comprises a wavelength selective mirror for allowing reflected light of a visible wavelength to be viewed at the proximal end of the headpiece and for allowing light of other wavelengths to be reflected between the distal end of the headpiece and the lower end of the handle.

13. The instrument of claim 10, further comprising a lens for forming light into a circular light beam.

14. The instrument of claim 7, wherein the applanation plate is circular.

15. The instrument of claim 7, wherein the compliant mount defines an annular mounting region for mounting the applanation plate relative to the reference surface.

16. The instrument of claim 15, wherein the mounting region is continuous or discontinuous.

17. The instrument of claim 7, wherein the compliant mount comprises an elastomeric structure.

18. The instrument of claim 17, wherein the elastomeric structure comprises an elastomeric O-ring.

19. The instrument of claim 17, wherein the elastomeric structure comprises a plurality of elastomeric posts circumferentially arranged to define an annular mounting region.

20. The instrument of claim 7, wherein the compliant mount comprises a compression spring.

21. The instrument of claim 20, wherein the compliant mount comprises a plurality of compression springs circumferentially arranged to define an annular mounting region.

22. A ophthalmic system for conducting simultaneous ocular tonometry and pachymetry measurements comprising:

an instrument as in claim 7;

and

an interferometer system operatively connected to the instrument for determining simultaneously intraocular pressure and corneal thickness conditions in response to optical signals propagating along a common optical signal path between the applanation plate and the interferometer.

23. A ophthalmic system for conducting simultaneous ocular tonometry and pachymetry measurements comprising:

an instrument having an applanation plate for contact with a cornea; and

an interferometer system operatively connected to the instrument for determining simultaneously intraocular pressure and corneal thickness conditions in response to optical signals propagating along a common optical signal path between the applanation plate and the interferometer.

24. The ophthalmic system of claim 23, further comprising a microprocessor operatively connected to the interferometer system.

25. The ophthalmic system of claim 23, wherein the instrument comprises a compliant mount which mounts the applanation plate for compliant displacements in response to corneal contact.

26. The ophthalmic system of claim 25, wherein the interferometer system optically determines intraocular pressure conditions in response to compliant displacement of the applanation plate.

27. The ophthalmic system of claim 26, wherein the interferometer system comprises (a) a source of light to be supplied to the instrument along the common optical signal path, and (b) a spectrometer for receiving reflected light from the instrument along the common optical signal path and generating a signal indicative of the intraocular pressure and corneal thickness.

28. The ophthalmic system of claim 25, wherein the compliant mount comprises an elastomeric or spring member.

29. The ophthalmic system of claim 28, wherein the compliant mount comprises a plurality of individual elastomeric or spring members.

30. A system for conducting simultaneous ocular tonometry and pachymetry measurements comprising:

an ophthalmic instrument having (i) a reference surface at a distal end of the instrument;

(ii) an applanation plate spaced from the reference surface; and

(iii) a compliant mount for mounting the applanation plate for resilient displacements relative to the reference surface; and

an interferometer for optical connection to the instrument, wherein

the interferometer comprises (a) a source of light to be supplied to the instrument, and (b) a spectrometer for receiving reflected light from the instrument and generating a signal indicative of a patient'"'"'s intraocular pressure and corneal thickness.

31. The system of claim 30, further comprising a microprocessor for receiving the signal generated by the interferometer and determining a patient'"'"'s intraocular pressure corrected for the patient'"'"'s corneal thickness.

32. A method for conducting simultaneous tonometry and pachymetry measurements of a patient'"'"'s eye, comprising:

(a) applanating a patient'"'"'s cornea; and

(b) simultaneously while applanating the patient'"'"'s cornea according to step (a), determining an intraocular pressure measurement in response to pressure of the applanated cornea and a corneal thickness measurement in response to optical illumination of the applanated cornea.

33. The method of claim 32, wherein step (a) comprises:

(a1) bringing into alignment with a patient'"'"'s cornea an ophthalmic instrument having (i) a reference surface at a distal end of the instrument;

(ii) an applanation plate spaced from the reference surface; and

(iii) a compliant mount for mounting the applanation plate for resilient displacements relative to the reference surface;

(a2) advancing the ophthalmic instrument toward the cornea so as to cause contact between the cornea and the applanation plate thereof; and

(a3) continuing to advance the ophthalmic instrument relative to the cornea to cause the applanation plate to be displaced resiliently toward the reference surface of the instrument until the cornea is flattened sufficiently against the applanation plate; and

wherein step (b) comprises;

(b1) directing a circular beam of light toward the flattened cornea and allowing light to be reflected therefrom; and

(b2) generating a signal from the reflected light which is indicative of a patient'"'"'s intraocular pressure and corneal thickness.

34. A method for conducting simultaneous tonometry and pachymetry measurements of a patient'"'"'s eye, comprising:

(a) bringing into alignment with a patient'"'"'s cornea an ophthalmic instrument having (i) a reference surface at a distal end of the instrument;

(ii) an applanation plate spaced from the reference surface; and

(iii) a compliant mount for mounting the applanation plate for resilient displacements relative to the reference surface;

(b) advancing the ophthalmic instrument toward the cornea so as to cause contact between the cornea and the applanation plate thereof;

(c) continuing to advance the ophthalmic instrument relative to the cornea to cause the applanation plate to be displaced resiliently toward the reference surface of the instrument until the cornea is flattened sufficiently against the applanation plate; and

(d) directing a circular beam of light toward the flattened cornea and allowing light to be reflected therefrom; and

(e) generating a signal from the reflected light which is indicative of a patient'"'"'s intraocular pressure and corneal thickness.

35. The method of claim 34, wherein step (e) is practiced to obtain a measurement of the patient'"'"'s intraocular pressure corrected by the patient'"'"'s corneal thickness.

36. The method of claim 35, wherein step (e) is practiced using a microprocessor.

37. An ophthalmic instrument system comprising:

an ophthalmic instrument having an applanation plate adapted to be placed adjacent to a patient'"'"'s cornea, a reference surface posteriorly spaced from the applanation plate, and compliant mounting means for mounting the applanation plate for resilient displacements relative to the reference surface;

a light source for providing light to the ophthalmic instrument; and

spectrometer means for receiving reflected light from the ophthalmic instrument and determining therefrom a displacement distance by which the applanation plate is moved resiliently towards the reference surface in response to a pressure force applied against the applanation plate by the patient'"'"'s cornea in contact therewith and generating a first distance signal indicative of the displacement distance; and

a microprocessor for receiving the first distance signal from the interferometer means and determining therefrom a patient'"'"'s intraocular pressure.

38. The ophthalmic instrument system as in claim 37, wherein the spectrometer means receives reflected light from the patient'"'"'s cornea and generates a second distance signal which is indicative of a corneal thickness dimension, and wherein the microprocessor receives the second distance signal to determine therefrom the patient'"'"'s corneal thickness dimension.

39. The ophthalmic instrument system of claim 38, wherein the microprocessor uses the first and second distance signals to determine therefrom the patient'"'"'s intraocular pressure condition corrected by the patients corneal thickness dimension.