System and method for determining airway obstruction

• US 20070123792A1
• Filed: 11/17/2005
• Published: 05/31/2007
• Est. Priority Date: 11/17/2005
• Status: Abandoned Application

• Current Assignee: Charlotte Mecklenburg Hospital Authority
• Original Assignee: Charlotte Mecklenburg Hospital Authority
• Inventors: Kline, Jeffrey
• Application Number:
  US11/282,012
• Publication Number:
  US 20070123792A1
• Time in Patent Office: Days
• US Class Current: 600/538
• CPC Class Codes: A61B 5/087 Measuring breath flow

Abstract

A method and system for detecting the presence of restriction to expired airflow in humans or animals by analyzing the expired capnogram and oxygram, as well as the geometric analysis of the real-time plot of the waveform that depicts the instantaneous ratio of CO₂ to O₂ (the carboxygram ratio). Airway obstructions causes an increase in the Q-angle between the slope of phase 11 and slope of phase III in the expired carboxygram. The diagnostic accuracy of the detection of airways obstruction is further enhanced by measuring the ratio of time spent in exhalation (Te) versus inhalation (Ti). The system uses the combination of an increased carboxygram Q-angle, and a prolonged Te/Ti to detect presence of airways obstruction.

Claims

1. A system for diagnosing the presence of abnormal respiratory function, comprising:

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a breathing tube through which a subject may take one or more breaths over a predetermined time period;

a flow meter connected to said tube;

an oxygen meter connecter to said tube;

a carbon dioxide meter connected to said tube; and

a microprocessor connected to said flow meter, said oxygen meter, said carbon dioxide meter, and said pulse oximeter, wherein said microprocessor is programmed to calculate the ratio of carbon dioxide to oxygen in said breaths in real-time.

2. The system of claim 1, wherein the microprocessor is programmed to correct for the differential response rates of carbon dioxide meters.

3. The system of claim 1, further comprising a display screen connected to said microprocessor.

4. The system of claim 3, wherein said display screen displays a plot of the ratios of the carbon dioxide to oxygen in real-time over said predetermined time period.

5. The system of claim 4, wherein said display screen displays the plot of the ratios of carbon dioxide to oxygen as a smoothed line.

6. The system of claim 3, wherein said display screen displays a plot of the ratios of the partial pressures of carbon dioxide to oxygen in real-time over a predetermined time period in combination with previously measured ratios of partial pressures of carbon dioxide to oxygen in normal and afflicted populations.

7. The system of claim 3, wherein said microprocessor is programmed to calculate a running average inspiration time and expiration time over a predetermined time period.

8. The system of claim 7, wherein said display screen displays a plot of the running average inspiration time and expiration time over a predetermined time period.

9. The system of claim 8, wherein said display screen displays the plot of the running average inspiration time and expiration time over a predetermined time period as a smooth line.

10. The system of claim 8, wherein said display screen displays a plot of the running average inspiration time and expiration time over a predetermined time period in combination with previously measured average inspiration time and expiration time in normal and afflicted populations.

11. The system of claim 3, wherein said microprocessor is programmed to calculate the straight line slope of a first predetermined portion of a plot of the ratio of carbon dioxide to oxygen.

12. The system of claim 11, wherein said microprocessor is programmed to calculate the straight line slope of a second predetermined portion of a plot of the ratio of carbon dioxide to oxygen.

13. The system of claim 12, wherein said microprocessor is programmed to determine the widest angle formed by the intersection of the straight line slope of the first predetermined portion and the straight line slope of the second predetermined portion.

14. The system of claim 3, wherein said microprocessor is programmed to calculate the first derivative of a first predetermined portion of a plot of the ratio of carbon dioxide to oxygen.

15. The system of claim 14, wherein said microprocessor is programmed to calculate the first derivative of a second predetermined portion of a plot of the ratio of carbon dioxide to oxygen.

16. The system of claim 15, wherein said microprocessor is programmed to calculate the difference in the maximum first derivative of the first predetermined portion minus the maximum first derivative of the second predetermined portion.

17. The system of claim 4, further including a database containing previously measured ratios of carbon dioxide to oxygen in normal and afflicted subjects interconnected to said microprocessor.

18. The system of claim 17, wherein said display screen displays the plot of the ratios of the carbon dioxide to oxygen in combination with a plot of the previously measured ratios of carbon dioxide to oxygen in normal and afflicted subjects.

19. A method of diagnosing the presence of abnormal respiratory function, said method comprising:

providing a patient with a device adapted for measuring inspired and expired carbon dioxide and oxygen and flow rate;

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measuring the flow rate and partial pressures of carbon dioxide and oxygen in tidal breaths over a predetermined time period;

computing the ratio of carbon dioxide to oxygen in real-time;

visually plotting the computed ratios of carbon dioxide to oxygen; and

determining the presence of abnormal respiratory function based on the slope of predetermined portions of the plot of the computed ratios of carbon dioxide to oxygen.

20. The method of claim 19, wherein the ratio of carbon dioxide to oxygen is plotted as a function of volume.

21. The method of claim 19, wherein the ratio of carbon dioxide to oxygen is plotted as a function of time.

22. The method of claim 19, wherein the step of determining the presence of abnormal respiratory function includes comparing the slope of predetermined portions of the plot of the computed ratios of carbon dioxide to oxygen to the slope of predetermined portions of the plot of the ratios of carbon dioxide to oxygen in normal and afflicted subjects.

23. A method of diagnosing the presence of abnormal respiratory function, said method comprising:

providing a patient with a device adapted for measuring inspired and expired carbon dioxide and oxygen and flow rate;

measuring inspired and expired carbon dioxide and oxygen and flow rate;

determining the start of inspiration and the start of expiration based upon predetermined absolute thresholds and the measured flow rates;

calculating the average inspiration time and expiration time over a predetermined period of time;

calculating the ratio of the average inspiratory time divided by the expiratory time over the predetermined period of time; and

displaying the calculated ratio of the average inspiratory time divided by the expiratory time over the predetermined period of time.

24. The method of claim 23, further comprising the step of displaying the calculated ratio of the average inspiratory time divided by the expiratory time in combination with previously measured ratios of average inspiratory time divided by the expiratory time in normal and afflicted subjects.

25. The method of claim 23, further comprising the step of determining the presence of an airways obstruction based on the difference between the calculated ratio of the average inspiratory time divided by the expiratory time and the previously measured ratios of average inspiratory time divided by the expiratory time in normal and afflicted subjects.