Devices and methods for detecting analytes in fluid samples

• US 20070128070A1
• Filed: 12/01/2005
• Published: 06/07/2007
• Est. Priority Date: 12/01/2005
• Status: Abandoned Application

• Current Assignee: ACON Biotech Company Limited (Abbott Laboratories Incorporated), Alere Switzerland GmbH (Abbott Laboratories Incorporated), Inverness Medical Switzerland GmbH (Abbott Laboratories Incorporated)
• Original Assignee: Alere Switzerland GmbH (Abbott Laboratories Incorporated)
• Inventors: Ling, Yun, Dai, Jielin, Wu, Yuzhang
• Application Number:
  US11/293,864
• Publication Number:
  US 20070128070A1
• Time in Patent Office: Days
• US Class Current: 422/58
• CPC Class Codes: A61B 10/0051 for taking saliva or sputum samples devices for receiving spittle A61J9/00
• CPC Class Codes: A61B 10/0096 Casings for storing test samples A61B10/0038 and A61B10/0045 take precedence; preservation of living parts of the human or animal body A01N1/02; containers for retaining a material to be analysed B01L3/50; containers for enzymology or microbiology C12M1/16; swab-sampler being part of enzymology or microbiology container C12M1/30
• CPC Class Codes: B01L 2200/026 Fluid interfacing between devices or objects, e.g. connectors, inlet details
• CPC Class Codes: B01L 2300/042 Caps; Plugs
• CPC Class Codes: B01L 2300/047 Additional chamber, reservoir
• CPC Class Codes: B01L 3/5023 with a sample being transported to, and subsequently stored in an absorbent for analysis
• CPC Class Codes: B01L 3/5029 using swabs
• CPC Class Codes: G01N 33/54388 based on lateral flow
• CPC Class Codes: G01N 33/558 using diffusion or migration of antigen or antibody immunochromatographic test strips G01N33/54387

Abstract

The present invention discloses a device for detecting the presence or amount of an analyte in a fluid sample. The device has a sample collector and a receiving cup for receiving and holding the sample collector within the receiving cup. The sample collector contains a compressible absorbent member for collecting the fluid sample, and has a first position and a second, locked position within the receiving cup. The absorbent member is uncompressed in the first position and is compressed and held within the cup in the second, locked position. The sample collector or the receiving cup has at least one test element having reagents for detecting the presence or amount of the analyte in the fluid sample. In one embodiment the test element is in fluid communication with the absorbent member when the sample collector is in the second, locked position. The present invention also discloses a method for detecting the presence or amount of an analyte in a fluid sample using the aforesaid device.

Claims

1. A device for detecting the presence or amount of an analyte in a fluid sample comprising:

a sample collector comprising a compressible absorbent member for collecting the fluid sample,

a receiving cup for receiving and holding the sample collector within the receiving cup, the sample collector having a first position and a second, locked position within the receiving cup, the absorbent member being uncompressed in the first position and being compressed and held within the cup in the second, locked position;

the sample collector comprising at least one test element having reagents for detecting the presence or amount of the analyte in the fluid sample, the test element being in fluid communication with the absorbent member when the sample collector is in the second, locked position.

2. The device of claim 1 wherein the sample collector comprises a test element holder housing the test element.

3. The device of claim 2 wherein the test element is in fluid communication with the absorbent member through a passageway in the sample collector connecting the absorbent member and the test element.

4. The device of claim 3 wherein an absorbent pad is positioned between the passageway and the test element and carries fluid from the passageway to the test element.

5. The device of claim 1 wherein the sample collector comprises circumferential screw threads, and the receiving cup comprises circumferential receiving threads.

6. The device of claim 5 wherein the screw threads and receiving threads are engaged when the sample collector is in the second, locked position.

7. The device of claim 6 wherein the receiving cup is sealed from fluid communication with the exterior when the sample collector is in the second, locked position.

8. The device of claim 1 wherein the sample collector and the receiving cup are joined by a snap fit connection when the sample collector is in the second, locked position.

9. The device of claim 1 wherein the absorbent member is a sponge suitable for placing in the mouth of a test subject, and the fluid sample is saliva.

10. The device of claim 2 wherein the sample collector comprises a flattened handle for manually gripping the sample collector.

16. A method for detecting the presence or amount of an analyte in a fluid sample using a device of claim 1 comprising:

placing a volume of fluid sample in the absorbent member;

inserting the sample collector into the receiving cup and moving the sample collector to the second, locked position; and

determining the presence or amount of analyte in the fluid sample.

17. The method of claim 16 wherein the fluid sample is saliva, and the saliva is placed in the absorbent member by placing the sample collector into the mouth of a test subject.

11. A device for detecting the presence or amount of an analyte in a fluid sample comprising:

a sample collector comprising screw threads and a compressible absorbent member for collecting the fluid sample,

a receiving cup for receiving and holding the sample collector within the receiving cup, the receiving cup comprising receiving threads;

the sample collector having a first position within the receiving cup, and a second, locked position within the receiving cup where the screw threads and receiving threads are engaged, the absorbent member being uncompressed in the first position and being compressed and held within the cup in the second, locked position;

the receiving cup directly connected to a test element holder containing at least one test element having reagents for detecting the presence or amount of the analyte in the fluid sample, the test element being in fluid communication with the absorbent member when the sample collector is in the second, locked position.

12. The device of claim 11 wherein the absorbent member is in fluid communication with the test element through a channel in the receiving cup when the sample collector is in the second, locked position.

13. The device of claim 11 wherein the receiving cup is sealed from fluid communication with the exterior when the sample collector is in the second, locked position.

14. The device of claim 11 wherein the absorbent member is a sponge suitable for placing in the mouth of a test subject, and the fluid sample is saliva.

15. The device of claim 11 wherein the test element holder comprises a flattened handle for manually gripping the sample collector.