Analytical Biochemistry System with Robotically Carried Bioarray
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Accused Products
Abstract
An analytical biochemistry system featuring a substrate with reactants immobilized thereon at fixed, known locations, a holder supporting the substrate and a manipulator for transporting the holder to a fixed sample and to an inspection station. The reactants are binding agents for a target biomolecule in a sample which forms a bound substance having a detectable characteristic. The holder may be a standard pipettor, optionally carried by a robot arm or hand as the manipulator to contact the sample for detection of the presence of target biomolecules within the sample. In one embodiment, the holder is a pipette tip within which the substrate is housed, or it may be a pipette adapter which bears the substrate and fits within the sample wells of a standard microtiter plate. After appropriate incubation, the substrate and holder may be moved from contact with the sample, and the substrate may be exposed to any necessary development steps before being moved by the manipulator to a location for probing, such as by a beam. Probing of the substrate is performed to identify binding or complexing of target biomolecules of the sample with the reactants immobilized on the substrate, and may be accomplished via fluorescence detection, light scattering, autoradiography, or some other detection method.
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Citations
118 Claims
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1-99. -99. (canceled)
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100. A device comprising:
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a) a substrate, with a top surface and a bottom surface, wherein the bottom surface of the substrate comprises at least one array, wherein the array comprises reactant binding agents for a plurality of target biomolecules in a sample to form a bound substance having a detectable characteristic for detection of biomolecules within the sample, wherein the substrate is disposed in a downward facing orientation such that the bottom surface of the substrate contacts the target biomolecules; and
b) a holder wherein the holder is attached to the top surface of the substrate, wherein the holder is sized to fit within a corresponding well of a microtiter plate. - View Dependent Claims (101, 102, 103, 104, 105, 106)
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107. A device for bearing a substrate having reactant binding agents for at least one target biomolecule in a sample to form a bound substance having a detectable characteristic for detection of target biomolecules within the sample, the device comprising:
a holder having a bracket with opposed prongs, the opposed prongs bearing the substrate with distinct reactants in a spaced-apart relations the substrate disposed in a downward-facing orientation, wherein the bracket of the pipette adapter is placed on the sample for contact of the sample with the substrate. - View Dependent Claims (108, 109, 110, 111, 112)
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113. A device bearing a substrate having an array of reactant binding agents for a plurality of target biomolecules in a sample to form a bound substance having a detectable characteristic for detection of biomolecules within the sample, the device comprising:
a holder having an end with a flat bottom surface, the flat bottom surface bearing the substrate having an array of reactants in a spaced-apart relations the substrate being disposed in a downward facing orientation, so that, the array of reactants on the substrate can be brought into contact with the sample at the flat bottom surface of the holder. - View Dependent Claims (114, 115, 116, 117, 118)
Specification