Novel Stra6 polypeptides
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Abstract
The present invention is directed to novel polypeptides having sequence similarity to Stra6, a murine retinoic acid responsive protein, and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
37 Citations
101 Claims
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1-21. -21. (canceled)
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23. An isolated Stra6 polypeptide comprising an amino acid sequence comprising at least about 80% sequence identity to the sequence of (a) amino acid residues from about 1 to about 667 of
FIG. 2 (SEQ ID NO:- 2), or (b) amino acid residues from about 1 to about 658 of
FIG. 7 (SEQ ID NO;
5). - View Dependent Claims (22, 24, 31, 32, 33, 83, 84, 85, 96, 98, 100, 101)
- 2), or (b) amino acid residues from about 1 to about 658 of
- 25. An isolated Stra6 polypeptide having at least about 80% sequence identity to the polypeptide encoded by (a) the cDNA insert of the vector deposited with the ATCC on Jan. 11, 2000 as ATCC Deposit No. PTA-1181 (DNA148380-2827), or (b) the cDNA insert of the vector deposited with the ATCC on Feb. 23, 2000 as ATCC Deposit No. PTA-1405 (DNA148389-2827-1).
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27. (canceled)
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28. An isolated Stra6 polypeptide comprising the sequence of (a) amino acid residues from 1 to about 667 of
FIG. 2 (SEQ ID NO:- 2), or (b) amino acid residues 1 to about 658 of
FIG. 7 (SEQ ID NO;
5), or (c) a fragment of (a) or (b) sufficient to provide a binding site for an anti-Stra6 antibody.
- 2), or (b) amino acid residues 1 to about 658 of
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29. An isolated polypeptide produced by (i) hybridizing a test DNA molecule under stringent conditions with a DNA molecule encoding a Stra6 polypeptide comprising (a) the sequence of amino acid residues from 1 to about 667 of
FIG. 2 (SEQ ID NO:- 2), or (b) the sequence of amino acid residues 1 to about 658 of
FIG. 7 (SEQ ID NO;
5), or (c) the complement of the DNA molecule of (a), (ii) culturing a host cell comprising said test DNA molecule under conditions suitable for the expression of said polypeptide, and (iii) recovering said polypeptide from the cell culture. - View Dependent Claims (30)
- 2), or (b) the sequence of amino acid residues 1 to about 658 of
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34-55. -55. (canceled)
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56. An isolated soluble Stra6 polypeptide comprising an amino acid sequence having at least about 80% sequence identity to amino acids 1 to X of
FIG. 2 (SEQ ID NO:- 2), or of
FIG. 7 (SEQ ID NO;
5), where X is any amino acid from 49 to 59 ofFIG. 2 (SEQ ID NO;
2) or ofFIG. 7 (SEQ ID NO;
5). - View Dependent Claims (57)
- 2), or of
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58-82. -82. (canceled)
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86-95. -95. (canceled)
Specification