Flexible light sources and detectors and applications thereof

• US 20070129613A1
• Filed: 11/18/2004
• Published: 06/07/2007
• Est. Priority Date: 11/18/2003
• Status: Abandoned Application

• Current Assignee: Qinetiq Limited (QinetiQ Group PLC)
• Original Assignee: Qinetiq Limited (QinetiQ Group PLC)
• Inventors: Kaushal, Tej, Sage, Ian, Rochester, Katie
• Application Number:
  US10/579,315
• Publication Number:
  US 20070129613A1
• Time in Patent Office: Days
• US Class Current: 600/310
• CPC Class Codes: A61B 2017/00057 Light
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: A61N 2005/0645 Applicators worn by the patient
• CPC Class Codes: A61N 2005/0651 Diodes
• CPC Class Codes: A61N 2005/0653 Organic light emitting diodes
• CPC Class Codes: A61N 5/062 Photodynamic therapy, i.e. excitation of an agent
• CPC Class Codes: H10K 2101/10 Triplet emission
• CPC Class Codes: H10K 50/11 characterised by the electroluminescent [EL] layers
• CPC Class Codes: H10K 50/85 Arrangements for extracting light from the devices
• CPC Class Codes: H10K 50/852 comprising a resonant cavity structure, e.g. Bragg reflector pair

Abstract

Flexible and conformal medical light sources and related diagnostic devices directed to monitoring blood characteristics (e.g. levels of CO, oxygen, or bilirubin) and photo-therapeutic devices for treatment of ailments such as psoriasis and some forms of cancer. The flexible light source preferably comprises one or more organic light emitting diodes on a flexible substrate. Light sources may also be used for purposes of treatment. The substrate can also form a integral strap for attachment of the device over or around the patient'"'"'s body. Optionally, the device comprises a photo-detector arranged to detect and monitor emissions from the sources. Flexible and conformal medical light detectors and devices are also provided.

Claims

1. A medical sensor comprising one or more flexible light emitting diodes formed upon respective regions of flexible substrate and one or more flexible photo-detectors formed upon respective regions of flexible substrate.

2. A medical sensor according to claim 1 in which the flexible light emitting diodes are formed upon a single flexible substrate.

3. A medical sensor according to claim 1 arranged to be sufficiently flexible to permit the light source, in operation, to conform to a portion of the body of a patient to which light from the light source is to be applied.

4. A medical sensor according to claim 1 in which the flexible light emitting source comprises an organic light emitting diode.

5. A medical sensor according to claim 1 in which the flexible light emitting diode emits light at a wavelength suitable for diagnosis or therapy of a medical condition of the human or animal body.

6. A medical sensor according to claim 1 in which the flexible light emitting diode emits light in the red to infra-red region of the spectrum.

7. A medical sensor according to claim 1 in which the flexible light emitting diode emits light in the near infra-red region of the spectrum.

8. A medical sensor according to claim 1 in which the flexible light emitting diode emits light in a non-visible region of the spectrum.

9. A medical sensor according to claim 1 comprising a plurality of flexible light emitting diodes arranged to emit light at mutually distinct wavelengths.

10. A medical sensor according to claim 1 comprising at least two light emitting diodes arranged to emit at mutually distinct wavelengths, the light emitting diodes being arranged such that light at those distinct wavelengths is emitted substantially evenly across the sum of the areas defined by the light emitting diodes emitting at those wavelengths.

12. A medical sensor according to claim 1 comprising a strap comprising attachment means for attachment of the medical light source around or to a patient'"'"'s body.

13. A medical sensor according to claim 12 in which the flexible substrate forms the strap.

14. A medical sensor according to claim 12 in which the attachment means is one of hook-and-loop means, barb-and-slot means, and self-adhesive means.

15. A medical sensor according to claim 1 in which the light emitting diode comprises a triplet emitter.

16. A medical sensor according to claim 1 in which the light emitting diode comprises one or more components arranged to wavelength-shift light emitted within the light source from a first wavelength to a second wavelength.

17. A medical sensor according to claim 16 comprising a fluorescent emitter and in which wavelength-shifting is at least partially achieved by means of a fluorescent emitter.

18. A medical sensor according to claim 16 comprising a wavelength-shifting grating and in which wavelength-shifting is at least partially achieved by means of the wavelength-shifting grating.

19. A medical sensor according to claim 16 comprising a micro-cavity and in which wavelength-shifting is at least partially achieved by means of the micro-cavity.

20. A medical sensor according to claim 19 in which the second wavelength is determined by tuning of the micro-cavity.

21. A medical sensor according to claim 20 in which the micro cavity is tuned to emit light at a third wavelength substantially perpendicular to the plane of the light emitting diode.

23. A medical sensor according to claim 1 in which at least one of the one or more flexible photodetectors is arranged so as, in operation, to detect light emitted by at least one of the flexible light emitting diodes.

24. A medical sensor according to claim 23 comprising two or more flexible light emitting diodes arranged to emit light on a time-interleaved basis.

25. A medical sensor according to claim 1 comprising a plurality of the medical light sources arranged, in operation, to emit light at wavelengths suitable for diagnosis of levels of at least one of oxygen, carbon monoxide, and bilirubin in a human or animal body.

26. A medical sensor according to claim 1 in which the light detector is an organic photovoltaic detector.

27. A method of operating a medical sensor according to claim 15 in a pulsed mode having a predetermined pulse period, such that the triplet emitter is activated for a period calculated to ensure that emissions fall to acceptable levels before a subsequent light pulse is emitted.

28. A method according to claim 27 in which the predetermined pulse period is less than or equal to 25 ms.

29. A method of operating a medical sensor according to claim 1 in a pulsed mode, timing of emitted light pulses being determined responsive to an indication of the pulse timing of a patient to which the sensor is applied.

11. (canceled)

22. (canceled)

30. (canceled)

31. (canceled)

32. An organic light emitting diode arrangement comprising an organic light emitting diode arranged to emit light in the blue region of the spectrum and a wavelength-converting layer arranged to convert blue emissions from the organic light emitting diode to emissions in the infra-red region of the spectrum.

33. An organic light emitting diode arrangement according to claim 32 in which the wavelength-converting layer comprises a phosphor based compound.

34. An organic light emitting diode arrangement according to claim 32 in which the wavelength-converting layer comprises an infra-red edge filter.

35. (canceled)

36. (canceled)