Progenitor Endothelial Cell Capturing with a Drug Eluting Implantable Medical Device
First Claim
1. An implantable medical device having a luminal surface, an abluminal surface and a coating;
- the coating comprising one or more layers of a matrix;
one or more pharmaceutical substances at least on the abluminal surface, and a ligand attached to said matrix and configured to capture circulating progenitor cells on at least the luminal surface of said device after implantation of said medical device into a patient.
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Accused Products
Abstract
A medical device for implantation into vessels or luminal structures within the body is provided, which stimulates positive blood vessel remodeling. The medical device, such as a stent and a synthetic graft, is coated with a pharmaceutical composition consisting of a controlled-release matrix and one or more pharmaceutical substances for direct delivery of drugs to surrounding tissues. The coating on the medical device further comprises a ligand such as a peptide, an antibody or a small molecule for capturing progenitor endothelial cells in the blood contacting surface of the device for restoring an endothelium at the site of injury. In particular, the drug-coated stents are for use, for example, in balloon angioplasty procedures for preventing or inhibiting restenosis.
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Citations
20 Claims
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1. An implantable medical device having a luminal surface, an abluminal surface and a coating;
- the coating comprising one or more layers of a matrix;
one or more pharmaceutical substances at least on the abluminal surface, and a ligand attached to said matrix and configured to capture circulating progenitor cells on at least the luminal surface of said device after implantation of said medical device into a patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 17, 18, 19, 20)
- the coating comprising one or more layers of a matrix;
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14. An implantable medical device having a luminal surface and a coating;
- said coating comprising one or more layers of a dextran matrix;
one or more pharmaceutical substances for inhibiting smooth muscle cell migration and proliferation and an antibody with affinity and specificity for binding an endothelial cell surface antigen in vivo. - View Dependent Claims (15, 16)
- said coating comprising one or more layers of a dextran matrix;
Specification