Biological specimen collection and transfer device and method of use

• US 20070134130A1
• Filed: 12/09/2005
• Published: 06/14/2007
• Est. Priority Date: 12/09/2005
• Status: Abandoned Application

• Current Assignee: Cytyc Corporation (Hologic Incorporated)
• Original Assignee: Cytyc Corporation (Hologic Incorporated)
• Inventors: Hutchins, Timothy, Sakal, Robert
• Application Number:
  US11/298,952
• Publication Number:
  US 20070134130A1
• Time in Patent Office: Days
• US Class Current: 422/63
• CPC Class Codes: G01N 1/2813 Producing thin layers of samples on a substrate, e.g. smearing, spinning-on G01N1/30 takes precedence
• CPC Class Codes: G01N 2035/0405 manipulating closing or opening means, e.g. stoppers, screw caps, lids or covers
• CPC Class Codes: G01N 35/0099 comprising robots or similar manipulators robots per se B25J

Abstract

A filtration based biological specimen collection and transfer system includes a vial cassette configured for accessibly storing a plurality of sample vials, a filter cassette configured for accessibly storing a plurality of filter cartridges, a slide cassette configured for accessibly storing a plurality of specimen slides, a specimen slide processor configured to receive a sample vial, a filter cartridge, and a specimen slide, a transport system including a movable arm having an effecter engagement mechanism; and a plurality of effecters. Each effecter is configured for engaging the movable arm, for retrieving the sample vials, the filter cartridges, or the specimen slides from the respective vial cassette, filter cassette, or slide cassette and positioning them in the specimen slide processor, and for retrieving the sample vials, the filter cartridges, or the specimen slides from the specimen slide processor.

Claims

1. A filtration based biological specimen collection and transfer system, comprising:

a vial cassette configured for accessibly storing a plurality of sample vials;

a filter cassette configured for accessibly storing a plurality of filter cartridges;

a slide cassette configured for accessibly storing a plurality of specimen slides;

a specimen slide processor configured to receive a sample vial, a filter cartridge, and a specimen slide;

a transport system including a movable arm having an effecter engagement mechanism; and

a plurality of effecters, each effecter configured for engaging the movable arm, for retrieving the sample vials, the filter cartridges, or the specimen slides from the respective vial cassette, filter cassette, or slide cassette and positioning them in the specimen slide processor, and for retrieving the sample vials, the filter cartridges, or the specimen slides from the specimen slide processor.

2. The filtration based biological specimen collection and transfer system of claim 1, the plurality of effecters further comprising a vial handler configured for retrieving a sample vial from the vial cassette and positioning it in the specimen slide processor, and for retrieving the sample vial from the specimen slide processor and repositioning it in the vial cassette.

3. The filtration based biological specimen collection and transfer system of claim 2, the vial handler further comprising a cap manipulator configured to remove a vial cap from and reattach the vial cap to the sample vial.

4. The filtration based biological specimen collection and transfer system of claim 1, the plurality of effecters further comprising a filter handler configured for retrieving a filter cartridge from the filter cassette and positioning it in the specimen slide processor, and for retrieving the filter cartridge from the specimen slide processor.

5. The filtration based biological specimen collection and transfer system of claim 4, the filter handler further comprising an elongated member configured to pierce a membrane in the filter cartridge.

6. The filtration based biological specimen collection and transfer system of claim 1, the plurality of effecters further comprising a slide handler configured for retrieving a specimen slide from the slide cassette and positioning it in the specimen slide processor, and for retrieving the specimen slide from the specimen slide processor.

7. The filtration based biological specimen collection and transfer system of claim 6, the slide handler further comprising a dispenser configured to apply a fluid onto the specimen slide.

8. The filtration based biological specimen collection and transfer system of claim 1, further comprising a dispenser configured to apply a fluid onto the specimen slide.

9. The filtration based biological specimen collection and transfer system of claim 8, wherein the dispenser is selected from the group consisting of a brush and a sprayer.

10. The filtration based biological specimen collection and transfer system of claim 8, wherein the fluid is selected from the group consisting of a stain and a fixative.

11. The filtration based biological specimen collection and transfer system of claim 1, further comprising a scanner configured to read vial indicia on the sample vial.

12. The filtration based biological specimen collection and transfer system of claim 1, further comprising a printer configured to mark the specimen slide with slide indicia.

13. A filtration based biological specimen collection and transfer system, comprising:

a vial cassette configured for accessibly storing a plurality of sample vials;

a filter cassette configured for accessibly storing a plurality of filter cartridges;

a slide cassette configured for accessibly storing a plurality of specimen slides;

a specimen slide processor configured to receive a sample vial, a filter cartridge, and a specimen slide;

a transport system including a movable arm having an effecter engagement mechanism;

a vial handler configured for retrieving a sample vial from the vial cassette and positioning it in the specimen slide processor, and for retrieving the sample vial from the specimen slide processor and repositioning it in the vial cassette;

a filter handler configured for retrieving a filter cartridge from the filter cassette and positioning it in the specimen slide processor, and for retrieving the filter cartridge from the specimen slide processor; and

a slide handler configured for retrieving a specimen slide from the slide cassette and positioning it in the specimen slide processor, and for retrieving the specimen slide from the specimen slide processor.

14. A method of automatically collecting and transferring a biological specimen, comprising:

providing a movable arm having an effecter engagement mechanism;

engaging a vial handler with the movable arm;

positioning a sample vial with the vial handler in a specimen slide processor;

engaging a filter handler with the movable arm;

positioning a filter cartridge with the filter handler in the specimen slide processor;

engaging a slide handler with the movable arm; and

positioning a specimen slide with the slide handler in the specimen slide processor.

15. The method of claim 14, further comprising removing a cap from the sample vial and reattaching the cap onto the sample vial with the vial handler.

16. The method of claim 14, further comprising piercing a membrane in the filter cartridge with the filter handler.

17. The method of claim 14, further comprising

positioning the specimen slide in a dispenser;

and

applying a stain to the specimen slide.

18. The method of claim 14, further comprising

positioning the specimen slide in a dispenser;

and

applying a fixative to the specimen slide.

19. The method of claim 14, further comprising

positioning the sample vial proximate to a scanner;

and

reading vial indicia on the sample vial.

20. The method of claim 14, further comprising

positioning the specimen slide in a printer;

and

marking slide indicia on the specimen slide.