Method for coating biocompatible substrates with antibiotics

• US 20070134287A1
• Filed: 12/09/2005
• Published: 06/14/2007
• Est. Priority Date: 12/09/2005
• Status: Abandoned Application

• Current Assignee: Biomet Manufacturing, LLC (Zimmer Biomet Holdings, Inc.)
• Original Assignee: Biomet Manufacturing, LLC (Zimmer Biomet Holdings, Inc.)
• Inventors: Troxel, Karen, White, Scott
• Application Number:
  US11/299,331
• Publication Number:
  US 20070134287A1
• Time in Patent Office: Days
• US Class Current: 424/423
• CPC Class Codes: A61F 2/30767 Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
• CPC Class Codes: A61F 2/32 for the hip
• CPC Class Codes: A61F 2/38 for elbows or knees
• CPC Class Codes: A61F 2/40 for shoulders
• CPC Class Codes: A61F 2/42 for wrists or ankles; for hands, e.g. fingers; for feet, e.g. toes
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2002/3092 having an open-celled or open-pored structure
• CPC Class Codes: A61F 2310/00011 Metals or alloys
• CPC Class Codes: A61F 2310/0097 Coating or prosthesis-covering structure made of pharmaceutical products, e.g. antibiotics
• CPC Class Codes: A61L 2300/406 Antibiotics
• CPC Class Codes: A61L 27/04 Metals or alloys
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence

Abstract

A method for coating a biocompatible substrate with an antibiotic is provided. The method includes dissolving at least one antibiotic in an antibiotic compatible solvent to provide an antibiotic solution. The antibiotic solution is applied to the substrate and the antibiotic compatible solvent is removed from the substrate. Methods of preparing a metallic implant and methods of providing localized antibiotic activity are also provided.

Claims

1. A method for coating a metallic substrate with an antibiotic layer, comprising:

a. dissolving at least one antibiotic in an antibiotic compatible solvent to provide an antibiotic solution;

b. applying the antibiotic solution to the metallic substrate; and

c. removing the antibiotic compatible solvent from the metallic substrate.

2. The method according to claim 1, wherein the at least one antibiotic is selected from the group consisting of:

macrolides and lincosamines, quinolones and fluoroquinolones, carbepenems, monobactams, aminoglycosides, glycopeptides, tetracyclines, sulfonamides, rifampins, oxazolidonones, and streptogramins, synthetic moieties thereof, and combinations thereof.

3. The method according to claim 1, wherein the antibiotic compatible solvent is selected from aqueous solvents and organic solvents.

4. The method according to claim 1, wherein the applying is selected from spraying, dipping, or spreading the antibiotic solution on at least a region of the metallic substrate.

5. The method according to claim 1, wherein the antibiotic solution comprises at least one of minocycline and rifampin.

6. The method according to claim 5, wherein the antibiotic compatible solvent comprises methanol.

7. The method according to claim 1, wherein the antibiotic layer has a density of less than about 800 μ

g/cm².

8. The method according to claim 1, further comprising applying an additional antibiotic layer having a different antibiotic.

9. The method according to claim 1, wherein the antibiotic remains adhered to the metallic substrate by a bonding force selected from van der Waals forces, ionic bonding, or hydrogen bonding between the antibiotic and the metal.

10. A method of preparing a metallic implant having an antibiotic layer, comprising:

a. dissolving at least one antibiotic in an antibiotic compatible solvent to provide an antibiotic solution;

b. applying the antibiotic solution to the metallic implant substrate;

c. removing the antibiotic compatible solvent from the metallic implant substrate; and

d. packaging the metallic implant without removing the antibiotic layer.

11. The method according to claim 10, wherein the antibiotic solution comprises at least one of minocycline and rifampin.

12. The method according to claim 10, wherein said packaging comprises vacuum packaging the implant.

13. The method according to claim 10, wherein the metallic implant is adapted for adherence to bone and for bone ingrowth.

14. The method according to claim 10, wherein the metallic implant comprises a porous region.

15. The method according to claim 10, wherein the metallic implant is adapted for cementless implantation into a subject.

16. A method of providing localized antibiotic activity, comprising:

a. providing a metallic implant having an antibiotic layer, wherein the antibiotic layer is applied directly to the metallic implant substrate;

b. delivering the metallic implant to an implant site; and

c. hydrating the antibiotic layer to release the antibiotic to the implant site.

17. The method according to claim 16, wherein the antibiotic layer comprises at least one of minocycline and rifampin.

18. The method according to claim 16, wherein the antibiotic layer has a density of less than about 800 μ

g/cm².

19. The method according to claim 16, wherein the hydrating occurs after delivering the metallic implant to the implant site.

20. The method according to claim 16, wherein the hydrating comprises contacting the metallic implant with fluids in the implant site.