THERAPEUTIC COMBINATIONS
First Claim
Patent Images
1. A pharmaceutical composition for oral administration comprising:
- (1) at least a pharmaceutically acceptable betaine, its pharmaceutically acceptable salts, and their mixtures, said betaine and salts thereof being in a form selected from the group consisting of release controlled form, delay release form, floating form, forms ready to be floating in contact with the gastric medium, forms ready to be floating in contact with the intestinal medium, and combinations thereof, and (2) at least an anti-cholesterol agent selected from the group consisting of;
A) pharmaceutically acceptable fibrates and pharmaceutically acceptable salts thereof;
B) pharmaceutically acceptable statins and pharmaceutically acceptable salts thereof;
C) pharmaceutically acceptable niacins and pharmaceutically acceptable salts thereof;
D) pharmaceutically acceptable bile sequestering agent and pharmaceutically acceptable salts thereof, and E) mixtures of these.
0 Assignments
0 Petitions
Accused Products
Abstract
The goal of the present invention is a pharmaceutical composition including a betaine and an anti-cholesterol agent. The association and co-administration of at least a betaine allows to reducing side effects related to anti-cholesterol agents administration, in particular their deleterious effects on liver, pancreas and kidneys.
-
Citations
80 Claims
-
1. A pharmaceutical composition for oral administration comprising:
-
(1) at least a pharmaceutically acceptable betaine, its pharmaceutically acceptable salts, and their mixtures, said betaine and salts thereof being in a form selected from the group consisting of release controlled form, delay release form, floating form, forms ready to be floating in contact with the gastric medium, forms ready to be floating in contact with the intestinal medium, and combinations thereof, and (2) at least an anti-cholesterol agent selected from the group consisting of;
A) pharmaceutically acceptable fibrates and pharmaceutically acceptable salts thereof;
B) pharmaceutically acceptable statins and pharmaceutically acceptable salts thereof;
C) pharmaceutically acceptable niacins and pharmaceutically acceptable salts thereof;
D) pharmaceutically acceptable bile sequestering agent and pharmaceutically acceptable salts thereof, and E) mixtures of these. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
-
-
30. A pharmaceutical composition for oral administration comprising:
-
(1) at least a pharmaceutically acceptable betaine, its pharmaceutically acceptable salts, and their mixtures, and (2) at least an anti-cholesterol agent selected from the group consisting of;
A) pharmaceutically acceptable fibrates and pharmaceutically acceptable salts thereof;
B) pharmaceutically acceptable statins and pharmaceutically acceptable salts thereof; and
C) mixtures thereof, whereby said composition comprises at least partly said anti-cholesterol agent in a form selected from the group consisting of anti-cholesterol agent at least partly dissolved into a phase comprising at least betaine, anti-cholesterol agent contained in a film coating particles comprising betaine, anti-cholesterol agent containing matrix in which betaine is dispersed, anti-cholesterol agent containing matrix comprising a dispersed solid or semi solid form containing betaine, and mixtures thereof. - View Dependent Claims (31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78)
-
-
79. A method of treatment of a patient suffering or at risk of suffering troubles related to cholesterol, in which said patient is administered a therapeutically effective amount of a pharmaceutical composition for oral administration comprising:
-
(1) at least a pharmaceutically acceptable betaine, its pharmaceutically acceptable salts, and their mixtures, said betaine and salts thereof being in a form selected from the group consisting of release controlled form, delay release form, floating form, forms ready to be floating in contact with the gastric medium, forms ready to be floating in contact with the intestinal medium, and combinations thereof, and (2) at least an anti-cholesterol agent selected from the group consisting of;
A) pharmaceutically acceptable fibrates and pharmaceutically acceptable salts thereof, B) pharmaceutically acceptable statins and pharmaceutically acceptable salts thereof, C) pharmaceutically acceptable niacins and pharmaceutically acceptable salts thereof;
D) pharmaceutically acceptable bile sequestering agent and pharmaceutically acceptable salts thereof; and
E) mixtures of these.
-
-
80. A method of treatment of a patient suffering or at risk of suffering troubles related to cholesterol, in which said patient is administered a therapeutically effective amount of a pharmaceutical composition for oral administration comprising:
-
(1) at least a pharmaceutically acceptable betaine, its pharmaceutically acceptable salts, and their mixtures, and (2) at least an anti-cholesterol agent selected from the group consisting of;
A) pharmaceutically acceptable fibrates and pharmaceutically acceptable salts thereof, B) pharmaceutically acceptable statins and pharmaceutically acceptable salts thereof, and C) mixtures thereof, whereby said composition comprises at least partly said anti-cholesterol agent in a form selected from the group consisting of anti-cholesterol agent at least partly dissolved into a phase comprising at least betaine, anti-cholesterol agent contained in a film coating particles comprising betaine, anti-cholesterol agent containing matrix in which betaine is dispersed, anti-cholesterol agent containing matrix comprising a dispersed solid or semi solid form containing betaine, and mixtures thereof.
-
Specification