High-Potency Sweetener Composition for Treatment and/or Prevention of Autoimmune Disorders and Compositions Sweetened Therewith

• US 20070134391A1
• Filed: 11/02/2006
• Published: 06/14/2007
• Est. Priority Date: 11/23/2005
• Status: Abandoned Application

• Current Assignee: The Coca-Cola Company
• Original Assignee: The Coca-Cola Company
• Inventors: Prakash, Indra, DuBois, Grant
• Application Number:
  US11/556,118
• Publication Number:
  US 20070134391A1
• Time in Patent Office: Days
• US Class Current: 426/548
• CPC Class Codes: A23L 2/38 Other non-alcoholic beverages drinks from legumes A23L11/60
• CPC Class Codes: A23L 2/52 Adding ingredients adding preservatives A23L2/44
• CPC Class Codes: A23L 2/60 Sweeteners
• CPC Class Codes: A23L 27/34 Sugar alcohols
• CPC Class Codes: A23L 27/36 Terpene glycosides
• CPC Class Codes: A23L 33/12 Fatty acids or derivatives thereof
• CPC Class Codes: A23L 33/135 Bacteria or derivatives thereof, e.g. probiotics
• CPC Class Codes: A23L 33/155 Vitamins A or D
• CPC Class Codes: A23L 33/175 Amino acids
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2250/1882 Polyunsaturated fatty acids
• CPC Class Codes: A23V 2250/262 Stevioside
• CPC Class Codes: A23V 2250/6402 Erythritol
• CPC Class Codes: A23V 2250/7106 Vitamin D3
• CPC Class Codes: A61P 37/00 Drugs for immunological or allergic disorders
• CPC Class Codes: A61P 37/06 Immunosuppressants, e.g. drugs for graft rejection

Abstract

The present invention relates generally to functional sweetener compositions comprising non-caloric or low-caloric high-potency sweeteners and methods for making and using them. In particular, the present invention relates to different functional sweetener compositions comprising at least one non-caloric or low-caloric natural and/or synthetic high-potency sweetener, at least one sweet taste improving composition, and at least one functional ingredient, such as an agent for the treatment and/or prevention of autoimmune disorders. The present invention also relates to functional sweetener compositions and methods that can improve the tastes of non-caloric or low-caloric natural and/or synthetic high-potency sweeteners by imparting a more sugar-like taste or characteristic. In particular, the functional sweetener compositions and methods provide a more sugar-like temporal profile, including sweetness onset and sweetness linger, and/or a more sugar-like flavor profile.

Claims

1. A functional sweetener composition comprising:

at least one agent for the treatment and/or prevention of autoimmune disorders;

at least one high-potency sweetener; and

at least one sweet taste improving composition.

2. The functional sweetener composition of claim 1, wherein the at least one agent for the treatment and/or prevention of autoimmune disorders comprises at least one probiotic, at least one prebiotic, at least one fatty acid, at least one antioxidant, at least one vitamin, or combinations thereof.

3. The functional sweetener composition of claim 2, wherein the at least one probiotic comprises a bacteria selected from the genus Bacillus, Lactobacillus, Bifodobacterium, and combinations thereof.

4. The functional sweetener composition of claim 2, wherein the at least one prebiotic comprises fructooligosaccharides, inulins, isomalto-oligosaccharides, lactilols, lactosucroses, lactuloses, pyrodextrins, soy oligosaccharides, transgalacto-oligosaccharides, xylo-oligosaccharides, or combinations thereof.

5. The functional sweetener composition of claim 2, wherein the at least one fatty acid comprises an omega-3-fatty acid.

6. The functional sweetener composition of claim 2, wherein the at least one antioxidant comprises vitamins, vitamin cofactors, minerals, hormones, carotenoids, carotenoid terpenoids, non-carotenoid terpenoids, flavonoids, flavonoid polyphenolics (e.g., bioflavonoids), flavonols, ilavones, phenols, polyphenols, esters of phenols, esters of polyphenols, nonflavonoid phenolics, isothiocyanates, or combinations thereof.

7. The functional sweetener composition of claim 2, wherein the at least one vitamin comprises vitamin P, vitamin B12, their vitamin precursors, or combinations thereof.

8. The functional sweetener composition of claim 1, wherein the at least one high-potency sweetener comprises a natural high-potency sweetener selected from the group consisting of rebaudioside A, rebaudioside B, rebaudioside C, rebaudioside D, rebaudioside E, rebaudioside F, duleoside A, dulcoside B, rubusoside, stevia, stevioside, mogroside IV, mogroside V, Duo Han Guo sweetener, siamenoside, monatin and its salts (monatin SS, RR, RS, SR), curculin, glycyrrhizic acid and its salts, thaumatin, monellin, mabinlin, brazzein, hernandulcin, phyllodulcin, glycyphyllin, phloridzin, trilobatin, baiyunoside, osladin, polypodoside A, pterocaryoside A, pterocaryoside B, mukurozioside, phlomisoside I, periandrin I, abrusoside A, cyclocarioside I, and combinations thereof

9. The functional sweetener composition of claim 1, wherein the at least one high-potency sweetener comprises a synthetic high-potency sweetener selected from the group consisting of sucralose, acesulfame potassium and other salts, aspartame, alitarne, saccharin, neohesperidin dihydrochalcone, cyclamate, neotame, N—

[N-[3-(3-hydroxy-4-methoxyphenyl)propyl]-L-α

-aspartyl]-L-phenylalanine 1-methyl ester, N—

[N-[3-(3-hydroxy-4-methoxyphenyl)-3-methylbutyl]-L-α

-aspartyl]-L-phenylalanine 1-methyl ester, N—

[N-[3-(3-methoxy-4-hydroxyphenyl)propyl]-L-α

-aspartyl]-L-phenylalanine 1-methyl ester, salts thereof, and combinations thereof.

10. The functional sweetener composition of claim 1, wherein the at least one sweet taste improving composition comprises a first sweet taste improving composition selected from the group consisting of carbohydrates, polyols, amino acids and their corresponding salts, polyamino acids and their corresponding salts, sugar acids and their corresponding salts, organic acids, inorganic acids, organic salts, inorganic salts, bitter compounds, flavorants, astringent compounds, polymers, protein hydrolysates, surfactants, emulsifiers, flavanoids, alcohols, and combinations thereof.

11. The functional sweetener composition of claim 1, wherein the at least one sweet taste improving composition imparts a more sugar-like temporal profile to the functional sweetener composition than the sweetener would have without the at least one sweet taste improving composition

12. The functional sweetener composition of claim 1, further comprising at least one second sweet taste improving composition different from the at least one first sweet taste improving composition and selected from the group consisting of carbohydrates, polyols, amino acids and their corresponding salts, polyamino acids and their corresponding salts, sugar acids and their corresponding salts, organic acids, inorganic acids, organic salts, inorganic salts, bitter compounds, flavorants, astringent compounds, polymers, protein hydrolysates, surfactants, emulsifiers, flavanoids, alcohols, and combinations thereof.

13. The functional sweetener composition of claim 12, further comprising at least one third sweet taste improving composition different from the at least one first sweet taste improving composition and the at least one second sweet taste improving composition and selected from the group consisting of carbohydrates, polyols, amino acids and their corresponding salts, polyamino acids and their corresponding salts, sugar acids and their corresponding salts, organic acids, inorganic acids, organic salts, inorganic salts, bitter compounds, flavorants, astringent compounds, polymers, protein hydrolysates, surfactants, emulsifiers, flavanoids, alcohols, and combinations thereof

14. The functional sweetener composition of claim 1, wherein the at least one high-potency sweetener comprises rebaudioside A, stevia, stevioside, or combinations thereof

15. The functional sweetener composition of claim 14, wherein the at least one sweet taste improving composition comprises at least one polyol.

16. The functional sweetener composition of claim 15, wherein the at least one polyol comprises erythritol.

17. The functional sweetener composition of claim 15, wherein the at least one polyol comprises xylitol.

18. The functional sweetener composition of claim 14, wherein the at least one sweet taste improving composition comprises at least one amino acid.

19. The functional sweetener composition of claim 18, wherein the at least one amino acid comprises glycine, alanine, proline, hydroxyproline, glutamine, or combinations thereof.

20. The functional sweetener composition of claim 14, wherein the at least one sweet taste improving composition comprises at least one polyamino acid.

21. The functional sweetener composition of claim 20, wherein the at least one polyamino acid comprises poly-L-aspartic acid, poly-L-α

-lysine, poly-L-ε

-lysine, poly-L-α

-ornithine, poly-ε

-ornithine, poly-L-arginine, salts thereof or combinations thereof.

22. The functional sweetener composition of claim 14, wherein the at least one sweet taste improving composition comprises at least one inorganic salt.

23. The functional sweetener composition of claim 22, wherein the at least one inorganic salt comprises a sodium, potassium, calcium, or magnesium salt.

24. The functional sweetener composition of claim 22, further comprising at least one inorganic phosphate.

25. The functional sweetener composition of claim 24, wherein the at least one inorganic phosphate comprises a sodium, potassium, calcium, or magnesium phosphate.

26. The functional sweetener composition of claim 22, further comprising at least one inorganic chloride.

27. The functional sweetener composition of claim 26, wherein the at least one inorganic chloride comprises a sodium, potassium, calcium, or magnesium chloride.

28. The functional sweetener composition of claim 14, wherein the at least one sweet taste improving composition comprises at least one carbohydrate.

29. The functional sweetener composition of claim 28, wherein the at least one carbohydrate comprises sucrose, high fructose corn syrup, glucose, or sucrose.

30. The functional sweetener composition of claim 29, wherein the at least one carbohydrate is present in the functional sweetener composition in an amount from about 10,000 ppm to about 80,000 ppm of the composition.

31. The functional sweetener composition of claim 14, wherein the at least one sweet taste improving composition comprises at least one synthetic high-potency sweetener.

32. The functional sweetener composition of claim 31, wherein the at least one synthetic high-potency sweetener comprises sucralose, acesulfame potassium or other salts, aspartame, alitame, saccharin, neohesperidin dihydrochalcone, cyclamate, neotame, N—

[N-[3-(3-hydroxy-4-methoxyphenyl)propyl]-L-α

-aspartyl]-L-phenylalanine 1-methyl ester, N—

[N-[3-(3-hydroxy-4-methoxyphenyl)-3-methylbutyl]-L-α

-aspartyl]-L-phenylalanine 1-methyl ester, N—

[N-[3-(3-methoxy-4-hydroxyphenyl)propyl]-L-α

-aspartyl]-L-phenylalanine 1-methyl ester, salts thereof, and combinations thereof.

33. The functional sweetener composition of claim 31, wherein the at least one synthetic high-potency sweetener comprises saccharin or acesulfame potassium or other salts.

34. The functional sweetener composition of claim 33, wherein the at least one synthetic sweetener is present in the functional sweetener composition in an amount from about 10 ppm to about 100 ppm of the composition.

35. The functional sweetener composition of claim 14, wherein the rebaudioside A comprises rebaudioside A in a purity greater than about 70% rebaudioside A by weight on a dry basis.

36. The functional sweetener composition of claim 14, wherein the rebaudioside A comprises rebaudioside A in a purity greater than about 80% rebaudioside A by weight on a dry basis.

37. The functional sweetener composition of claim 14, wherein the rebaudioside A comprises rebaudioside A in a purity greater than about 90% rebaudioside A by weight on a dry basis.

38. The functional sweetener composition of claim 14, wherein the rebaudioside A comprises rebaudioside A in a purity greater than about 97% rebaudioside A by weight on a dry basis.

39. The functional sweetener composition of claim 14, wherein the rebaudioside A comprises rebaudioside A in a purity greater than about 98% rebaudioside A by weight on a dry basis.

40. The functional sweetener composition of claim 14, wherein the rebaudioside A comprises rebaudioside A in a purity greater than about 99% rebaudioside A by weight on a dry basis.

41. A functional sweetened composition comprising:

a sweetenable composition;

at least one agent for the treatment and/or prevention of autoimmune disorders;

at least one high-potency sweetener; and

at least one sweet taste improving composition.

42. The functional sweetened composition of claim 41, wherein the at least one agent for the treatment and/or prevention of autoimmune disorders comprises at least one probiotic, at least one prebiotic, at least one fatty acid, at least one antioxidant, at least one vitamin, or combinations thereof.

43. The functional sweetened composition of claim 42, wherein the at least one probiotic comprises a bacteria selected from the genus Bacillus, Lactobacillus, Bifodobacterium, and combinations thereof.

44. The functional sweetened composition of claim 42, wherein the at least one prebiotic comprises fructooligosaccharides, inulins, isomalto-oligosaccharides, lactilols, lactosucroses, lactuloses, pyrodextrins, soy oligosaccharides, transgalacto-oligosaccharides, xylo-oligosaccharides, or combinations thereof.

45. The functional sweetened composition of claim 42, wherein the at least one fatty acid comprises an omega-3-fatty acid.

46. The functional sweetened composition of claim 42, wherein the at least one antioxidant comprises vitamins, vitamin cofactors, minerals, hormones, carotenoids, carotenoid terpenoids, non-carotenoid terpenoids, flavonoids, flavonoid polyphenolics (e.g., bioflavonoids), flavonols, flavones, phenols, polyphenols, esters of phenols, esters of polyphenols, nonflavonoid phenolics, isothiocyanates, or combinations thereof.

47. The functional sweetened composition of claim 42, wherein the at least one vitamin comprises vitamin D, vitamin B12, their vitamin precursors, or combinations thereof.

48. The functional sweetened composition of claim 41, wherein the at least one high-potency sweetener comprises at least one natural high-potency sweetener selected from the group consisting of rebaudioside A, rebaudioside B, rebaudioside C, rebaudioside D, rebaudioside E, rebaudioside F, dulcoside A, dulcoside B, rubusoside, stevia, stevioside, mogroside IV, mogroside V, Luo Han Guo sweetener, siamenoside, monatin and its salts (monatin SS, KR, RS, SR), curculin, glycyrrhizic acid and its salts, thaumatin, monellin, mabinlin, brazzein, hernandulcin, phyllodulcin, glycyphyllin, phloridzin, trilobatin, baiyunoside, osladin, polypodoside A, pterocaryoside A, pterocaryoside B, mukurozioside, phlomisoside I, periandrin I, abrusoside A, cyclocarioside I, and combinations thereof.

49. The functional sweetened composition of claim 41, wherein the at least one high-potency sweetener comprises a synthetic high-potency sweetener selected from the group consisting of sucralose, acesulfame potassium and other salts, aspartame, alitame, saccharin, neohesperidin dihydrochalcone, cyclamate, neotame, N—

[N-[3-(3-hydroxy-4-methoxyphenyl)propyl]-L-α

-aspartyl]-L-phenylalanine, methyl ester, N—

[N-[3-(3-hydroxy-4-methoxyphenyl)-3-methylbutyl]-L-α

-aspartyl]-L-phenylalanine, methyl ester, N—

[N-[3-(3-methoxy-4-hydroxyphenyl)propyl]-L-α

-aspartyl]-L-phenylalanine, methyl ester, salts thereof, and combinations thereof.

50. The functional sweetened composition of claim 41, wherein the at least one sweet taste improving composition comprises a first sweet taste improving composition selected from the group consisting of carbohydrates, polyols, amino acids and their corresponding salts, polyamino acids and their corresponding salts, sugar acids and their corresponding salts, organic acids, inorganic acids, organic salts, inorganic salts, bitter compounds, flavorants, astringent compounds, polymers, protein hydrolysates, surfactants, emulsifiers, flavonoids, alcohols, chelating agents, and combinations thereof.

51. The functional sweetened composition of claim 41, wherein the at least one sweet taste improving composition imparts a more sugar-like temporal profile to the sweetened composition than the at least one high-potency sweetener would have without the at least one sweet taste improving composition.

52. The functional sweetened composition of claim 50, further comprising at least one second sweet taste improving composition different from the at least one first sweet taste improving composition and selected from the group consisting of carbohydrates, polyols, amino acids and their corresponding salts, polyamino acids and their corresponding salts, sugar acids and their corresponding salts, organic acids, inorganic acids, organic salts, inorganic salts, bitter compounds flavorants, astringent compounds, polymers, protein hydrolysates, surfactants, emulsifiers, flavonoids, alcohols, chelating agents, and combinations thereof.

53. The functional sweetened composition of claim 52, further comprising at least one third sweet taste improving composition different from the at least one first sweet taste improving composition and the at least one second sweet taste improving composition and selected from the group consisting of carbohydrates, polyols, amino acids and their corresponding salts, polyamino acids and their corresponding salts, sugar acids and their corresponding salts, organic acids, inorganic acids, organic salts, inorganic salts, bitter compounds, flavorants, astringent compounds, polymers, protein hydrolysates, surfactants, emulsifiers, flavonoids, alcohols, chelating agents, and combinations thereof.

54. The functional sweetened composition of claim 41, wherein the at least one high-potency sweetener is rebaudioside A, stevia, stevioside, or combinations thereof.

55. The functional sweetened composition of claim 54, wherein the at least one sweet taste improving composition comprises at least one polyol,

56. The functional sweetened composition of claim 55, wherein the at least one polyol comprises erythritol.

57. The functional sweetened composition of claim 55, wherein the at least one polyol comprises xylitol.

58. The functional sweetened composition of claim 54, wherein the at least one sweet taste improving composition comprises at least one amino acid.

59. The functional sweetened composition of claim 58, wherein the at least one amino acid comprises glycine, alanine, proline, hydroxyproline, glutamine, or combinations thereof.

60. The functional sweetened composition of claim 54, wherein the at least one sweet taste improving composition comprises at least one polyamino acid.

61. The functional sweetened composition of claim 60, wherein the at least one polyamino acid comprises poly-L-aspartic acid, poly-L-lysine, poly-L-ornithine, poly-ε

-ornithine, poly-L-arginine, salts thereof, or combinations thereof.

62. The functional sweetened composition of claim 54, wherein the at least one sweet taste improving composition comprises at least one inorganic salt.

63. The functional sweetened composition of claim 62, wherein the at least one inorganic salt comprises a sodium, potassium, calcium, or magnesium salt.

64. The functional sweetened composition of claim 62, further comprising at least one inorganic phosphate.

65. The functional sweetened composition of claim 64, wherein the at least one inorganic phosphate comprises a sodium, potassium, calcium, or magnesium phosphate,

66. The functional sweetened composition of claim 62, further comprising at least one inorganic chloride.

67. The functional sweetened composition of claim 66, wherein the at least one inorganic chloride comprises a sodium, potassium, calcium, or magnesium chloride.

68. The functional sweetened composition of claim 54, wherein the at least one sweet taste improving composition comprises at least one carbohydrate.

69. The functional sweetened composition of claim 68, wherein the at least one carbohydrate comprises sucrose, high fructose corn syrup, glucose, or sucrose.

70. The functional sweetened composition of claim 69, wherein the at least one carbohydrate is present in the functional sweetened composition in an amount from about 10,000 ppm to about 80,000 ppm of the composition.

71. The functional sweetened composition of claim 54, wherein the at least one sweet taste improving composition comprises at least one synthetic high-potency sweetener.

72. The functional sweetened composition of claim 71, wherein the at least one synthetic high-potency sweetener comprises sucralose acesulfame potassium or other salts, aspartame, alitame, saccharin, neohesperidin dihydrochalcone, cyclamate, neotame, N—

[N-[3-(3-hydroxy-4-methoxyphenyl)propyl]-L-α

-aspartyl]-L-phenylalanine 1-methyl ester, N—

[N-[3-(3-hydroxy-4-methoxyphenyl)-3-methylbutyl]-L-α

-aspartyl]-L-phenylalanine 1-methyl ester, N—

[N-[3-(3-methoxy-4-hydroxyphenyl)propyl]-L-α

-aspartyl]-L-phenylalanine 1-methyl ester, salts thereof, and combinations thereof.

73. The functional sweetened composition of claim 71, wherein the at least one synthetic high-potency sweetener comprises saccharin or acesulfame potassium or other salts.

74. The functional sweetened composition of claim 73, wherein the at least one synthetic sweetener is present in the functional sweetened composition in an amount from about 10 ppm to about 100 ppm of the composition.

75. The functional sweetened composition of claim 54, wherein the rebaudioside A comprises rebaudioside A in a purity greater than about 70% rebaudioside A by weight on a dry basis.

76. The functional sweetened composition of claim 54, wherein the rebaudioside A comprises rebaudioside A in a purity greater than about 80% rebaudioside A by weight on a dry basis.

77. The functional sweetened composition of claim 54, wherein the rebaudioside A comprises rebaudioside A in a purity greater than about 90% rebaudioside A by weight on a dry basis.

78. The functional sweetened composition of claim 54, wherein the rebaudioside A comprises rebaudioside A in a purity greater than about 97% rebaudioside A by weight on a dry basis.

79. The functional sweetened composition of claim 54, wherein the rebaudioside A comprises rebaudioside A in a purity greater than about 98% rebaudioside A by weight on a dry basis.

80. The functional sweetened composition of claim 54, wherein the rebaudioside A comprises rebaudioside A in a purity greater than about 99% rebaudioside A by weight on a dry basis.

81. The functional sweetened composition of claim 54, wherein the sweetened composition comprises a food, beverage, pharmaceutical, tobacco, nutraceutical, oral hygienic, or cosmetic.

82. A functional beverage comprising the sweetened composition of claim 54.

83. The functional beverage of claim 82, wherein the beverage is a non-carbonated beverage or a carbonated beverage.

84. The functional beverage of claim 83, wherein the carbonated beverage is a cola.

85. The functional beverage of claim 83, wherein the carbonated beverage is a fruit-flavored beverage.

86. The functional beverage of claim 83, wherein the carbonated beverage is a citrus-flavored beverage.

87. The functional beverage of claim 86, wherein the citrus-flavored beverage is a lemon-lime flavored beverage or a orange-flavored beverage.

88. The functional beverage of claim 83, wherein the carbonated beverage is a root beer.

89. The functional beverage of claim 82, wherein the beverage is a fruit juice, fruit-flavored, or fruit-containing beverage.

90. The functional beverage of claim 82, wherein the beverage is a vegetable juice or vegetable containing beverage.

91. The functional beverage of claim 82, wherein the beverage is tea.

92. The functional beverage of claim 82, wherein the beverage is coffee.

93. The functional beverage of claim 82, wherein the beverage comprises a dairy component.

94. The functional beverage of claim 82, wherein the beverage is a sports drink.

95. The functional beverage of claim 82, wherein the beverage is an energy drink.

96. The functional beverage of claim 82, wherein the beverage is a flavored water.