Compositions and capsules with stable hydrophilic layers
First Claim
Patent Images
1. A capsule comprising a hydrophobic inner core and at least one hydrophilic outer layer;
- said outer layer comprises at least one hygroscopic polyol and at least one polyol with a low hygroscopicity.
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Abstract
Several embodiments of the present invention provide a capsule including a hydrophobic inner core layer and at least one hydrophilic outer layer. The outer layer may be seamless and may include at least one hygroscopic polyol and at least one polyol with a low hygroscopicity. The at least one outer layer may include at least one film or gel forming agent. Such capsules are stable and experience minimal or no degradation under accelerated stability conditions.
50 Citations
20 Claims
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1. A capsule comprising a hydrophobic inner core and at least one hydrophilic outer layer;
- said outer layer comprises at least one hygroscopic polyol and at least one polyol with a low hygroscopicity.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A capsule comprising a hydrophobic inner core and at least one hydrophilic outer layer;
- said outer layer comprises at least one film or gel forming agent, at least one hygroscopic polyol and at least one polyol with a low hygroscopicity;
said hydrophobic inner core comprises at least one active pharmaceutical ingredient in a pharmaceutically effective amount and said at least one outer layer experiences minimal degradation at 30°
C./65% relative humidity.
- said outer layer comprises at least one film or gel forming agent, at least one hygroscopic polyol and at least one polyol with a low hygroscopicity;
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20. A package comprising a capsule comprising a hydrophobic inner core and at least one hydrophilic outer layer;
- said outer layer comprises at least one hygroscopic polyol and at least one polyol with a low hygroscopicity;
said package comprises drug facts attached thereto.
- said outer layer comprises at least one hygroscopic polyol and at least one polyol with a low hygroscopicity;
Specification