Apparatus and method for measuring activity signals of biological samples
0 Assignments
0 Petitions
Accused Products
Abstract
The present invention provides an apparatus for measuring activity signals of a biological sample comprising: a measurement chamber (A) storing a target liquid containing a biological sample; a porous insulating substrate (5) provided with a measurement electrode (1) on at least one side; and a conveying device (8) which conveys the target liquid stored in the measurement chamber (A) and passes the target liquid through the porous insulating substrate (5) from the measurement electrode (1) side, wherein the conveying device (8) is operated to trap the biological sample contained in the target liquid onto the measurement electrode (1), so that the activity signals of the biological sample are measured through the measurement electrode (1). According to the apparatus, activity signals emitted from the biological sample can be detected easily, rapidly and accurately.
-
Citations
24 Claims
-
1-12. -12. (canceled)
-
13. An apparatus for measuring activity signals of a biological sample comprising:
a measurement chamber storing a target liquid containing a biological sample;
a porous insulating substrate provided with a measurement electrode on at least one side; and
a conveying device which conveys the target liquid stored in the measurement chamber and passes the target liquid through the porous insulating substrate from the measurement electrode side, wherein the conveying device is operated to trap the biological samples contained in the target liquid onto the measurement electrode, so that the activity signals of the biological samples are measured through the measurement electrode.
-
14. An apparatus for measuring activity signals of a biological sample according to claim 13, further comprising a reference electrode that is provided in the measurement chamber.
-
15. An apparatus for measuring activity signals of a biological sample according to claim 13, wherein the conveying device further comprises a suction apparatus for sucking and then passing the target liquid through the porous insulating substrate.
-
16. An apparatus for measuring activity signals of a biological sample according to claim 15, wherein the porous insulating substrate is detachably provided between the measurement chamber and the suction apparatus.
-
17. An apparatus for measuring activity signals of a biological sample according to claim 13, wherein the porous insulating substrate is composed of a resin film having a pore diameter of not more than 1 μ
- m but not less than 1,000 μ
m and a thickness of not more than 1 μ
m but not less than 10,000 μ
m.
- m but not less than 1,000 μ
-
18. An apparatus for measuring activity signals of a biological sample according to claim 13, further comprising:
- a conductor electrically connected to the measurement electrode, wherein the conductor is formed on one side of the porous insulating substrate via a mask layer and the measurement electrode is infused into the porous insulating substrate more deeply than the conductor.
-
19. An apparatus for measuring activity signals of a biological sample according to claim 18, wherein the measurement electrode and the conductor are formed by sputtering a conductive material onto a surface of the porous insulating substrate.
-
20. An apparatus for measuring activity signals of a biological sample according to claim 13, wherein the measurement chamber and the conductor are provided in plural;
- the conveying device is provided with a common suction line communicating with each of the measurement chambers; and
the conveying device is operated to simultaneously trap the biological samples contained in the target liquid stored in the measurement chambers onto the corresponding measurement electrodes.
- the conveying device is provided with a common suction line communicating with each of the measurement chambers; and
-
21. An apparatus for measuring activity signals of a biological sample according to claim 20, further comprising a plurality of reference electrodes provided in the plurality of measurement chambers, respectively.
-
22. An apparatus for measuring activity signals of a biological sample according to claim 13, further comprising:
- a means for calculating the standard deviation per a predetermined number of samples based on time-series data of activity signals outputted via the measurement electrode;
a means for calculating the mean value of a plurality of the obtained standard deviations;
a means for evaluating the activity of the biological samples based on the obtained mean value of the standard deviations; and
a means for displaying the results of the activity evaluation.
- a means for calculating the standard deviation per a predetermined number of samples based on time-series data of activity signals outputted via the measurement electrode;
-
23. An apparatus for measuring activity signals of a biological sample according to claim 13, further comprising:
- a means for calculating the standard deviation per a predetermined number of samples based on time-series data of activity signals outputted via the measurement electrode;
a means for classifying the obtained plurality of the standard deviations into a plurality of classes set by a predetermined width and approximating the classification results to the normal distribution;
a means for evaluating the activity of the biological samples based on the obtained normal distribution; and
a means for displaying the results of the activity evaluation.
- a means for calculating the standard deviation per a predetermined number of samples based on time-series data of activity signals outputted via the measurement electrode;
-
24. An apparatus for measuring activity signals of a biological sample according to claim 23, further comprising:
- a means for calculating the mean value and half-width of the obtained normal distribution, wherein the activity is evaluated based on the obtained mean value and half-width of the normal distribution.
Specification