ELECTRODE ASSEMBLY FOR IONTOPHORESIS FOR ADMINISTERING ACTIVE AGENT ENCLOSED IN NANOPARTICLE AND IONTOPHORESIS DEVICE USING THE SAME

• US 20070135754A1
• Filed: 09/29/2006
• Published: 06/14/2007
• Est. Priority Date: 09/30/2005
• Status: Abandoned Application

• Current Assignee: TTI Ellebeau, Inc. (Ease Asset Management Ltd.)
• Original Assignee: TTI Ellebeau, Inc. (Ease Asset Management Ltd.)
• Inventors: Nakayama, Mizuo, Matsumura, Akihiko, Matsumura, Takehiko, Akiyama, Hidero
• Application Number:
  US11/537,459
• Publication Number:
  US 20070135754A1
• Time in Patent Office: Days
• US Class Current: 604/20
• CPC Class Codes: A61N 1/044 Shape of the electrode
• CPC Class Codes: A61N 1/0444 Membrane
• CPC Class Codes: A61N 1/0448 Drug reservoir

Abstract

An electrode assembly for iontophoresis may enable the administration of a non-ionic active agent ionized, or an active agent that is substantially insoluble in water, by iontophoresis. An electrode assembly used for iontophoresis may hold an active agent enclosed in an ionic nanoparticle.

Claims

1. An electrode assembly for iontophoresis, comprising;

an active agent enclosed in an ionic nanoparticle; and

an electrode operable to apply an electromotive force that drives the ionic nanoparticle from the electrode assembly.

2. The electrode assembly according to claim 1, further comprising:

an electric power source operable to apply an electrical potential to the electrode.

3. The electrode assembly according to claim 2, further comprising in order from an interior of the electrode assembly to an exterior thereof:

an electrolyte solution reservoir that holds an electrolyte solution, the electrolyte solution reservoir proximate the electrode;

a first ion exchange membrane that selectively passes ions having a polarity opposite that of the ionic nanoparticles;

an active agent solution reservoir that holds ionic nanoparticles; and

a second ion exchange membrane that selectively passes ions having the same polarity as that of the ionic nanoparticles.

4. The electrode assembly according to claim 3, wherein the active agent solution reservoir includes pores capable of holding and passing the ionic nanoparticle.

5. The electrode assembly according to claim 3, wherein the second ion exchange membrane includes pores capable of passing the ionic nanoparticle, and wherein the first ion exchange membrane does not include pores capable of passing the ionic nanoparticle.

6. The electrode assembly according to claim 1, wherein the ionic nanoparticle comprises a cationic nanoparticle.

7. The electrode assembly according to claim 1, wherein the ionic nanoparticle comprises an anionic nanoparticle.

8. The electrode assembly according to claim 1, wherein the active agent enclosed in the ionic nanoparticle is selected from the group consisting of cancer therapeutic agents, nucleic acids such as genes, and peptides.

9. An iontophoresis device comprising:

an electric power source device;

active agent administration means comprising two or more electrode assemblies, at least one of the electrode assemblies having a plurality of ionic nanoparticles and an electrode; and

current control means for controlling a current flow to the electrode assemblies from the electric power source device, current flow from the current control means releasing the ionic nanoparticle to be administered transdermally to a subject.

10. The iontophoresis device according to claim 9, wherein the active agent administration means is configured integrally.