CYTOKINE RECEPTOR ZCYTOR17 MULTIMERS
First Claim
1. A method of reducing zcytor17lig-induced inflammation in a mammal suffering from an inflammatory disease comprising administering to the mammal an effective amount of a composition comprising a soluble receptor polypeptide comprising amino acid residues 20-519 of SEQ ID NO:
- 111, wherein the soluble receptor polypeptide forms a heterodimeric or multimeric soluble receptor polypeptide with a second soluble receptor polypeptide comprising amino acid residues 28-739 of SEQ ID NO;
7; and
a pharmaceutically acceptable vehicle, wherein after administration the inflammation is reduced.
0 Assignments
0 Petitions
Accused Products
Abstract
Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.
-
Citations
8 Claims
-
1. A method of reducing zcytor17lig-induced inflammation in a mammal suffering from an inflammatory disease comprising administering to the mammal an effective amount of a composition comprising a soluble receptor polypeptide comprising amino acid residues 20-519 of SEQ ID NO:
- 111, wherein the soluble receptor polypeptide forms a heterodimeric or multimeric soluble receptor polypeptide with a second soluble receptor polypeptide comprising amino acid residues 28-739 of SEQ ID NO;
7; and
a pharmaceutically acceptable vehicle, wherein after administration the inflammation is reduced. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
- 111, wherein the soluble receptor polypeptide forms a heterodimeric or multimeric soluble receptor polypeptide with a second soluble receptor polypeptide comprising amino acid residues 28-739 of SEQ ID NO;
Specification