CYTOKINE RECEPTOR ZCYTOR17 MULTIMERS

• US 20070140963A1
• Filed: 10/26/2006
• Published: 06/21/2007
• Est. Priority Date: 01/18/2002
• Status: Abandoned Application

• Current Assignee: Zymogenetics Incorporated (Bristol-Myers Squibb Company)
• Original Assignee: Zymogenetics Incorporated (Bristol-Myers Squibb Company)
• Inventors: Gao, Zeren, Grant, Francis, Dasovich, Maria, Hammond, Angela, Kuijper, Joseph, Dillon, Stacey, Whitmore, Theodore, Gross, Jane, Presnell, Scott, Sprecher, Cindy, Novak, Julia
• Application Number:
  US11/553,219
• Publication Number:
  US 20070140963A1
• Time in Patent Office: Days
• US Class Current: 424/1.490
• CPC Class Codes: A01K 2217/05 Animals comprising random inserted nucleic acids (transgenic)
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61P 1/02 Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
• CPC Class Codes: A61P 1/04 for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
• CPC Class Codes: A61P 1/16 for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• CPC Class Codes: A61P 1/18 for pancreatic disorders, e.g. pancreatic enzymes
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 11/06 Antiasthmatics
• CPC Class Codes: A61P 13/08 of the prostate
• CPC Class Codes: A61P 15/00 Drugs for genital or sexual disorders for disorders of sex hormones A61P5/24; Contraceptives
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/04 Antipruritics
• CPC Class Codes: A61P 17/06 Antipsoriatics
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 37/00 Drugs for immunological or allergic disorders
• CPC Class Codes: A61P 37/06 Immunosuppressants, e.g. drugs for graft rejection
• CPC Class Codes: A61P 37/08 : Antiallergic agents antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14
• CPC Class Codes: A61P 39/02 : Antidotes
• CPC Class Codes: A61P 43/00 : Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C07K 14/52 : Cytokines; Lymphokines; Interferons
• CPC Class Codes: C07K 14/715 : for cytokines; for lymphokines; for interferons
• CPC Class Codes: C07K 16/2866 : against receptors for cytokines, lymphokines, interferons
• CPC Class Codes: C07K 2317/24 : containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
• CPC Class Codes: C07K 2317/76 : Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Abstract

Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.

Claims

1. A method of reducing zcytor17lig-induced inflammation in a mammal suffering from an inflammatory disease comprising administering to the mammal an effective amount of a composition comprising a soluble receptor polypeptide comprising amino acid residues 20-519 of SEQ ID NO:

111, wherein the soluble receptor polypeptide forms a heterodimeric or multimeric soluble receptor polypeptide with a second soluble receptor polypeptide comprising amino acid residues 28-739 of SEQ ID NO;

7; and

a pharmaceutically acceptable vehicle, wherein after administration the inflammation is reduced.

2. The method of claim 1 wherein the heterodimeric or multimeric soluble receptor polypeptide is fused to an immunoglobulin heavy chain constant region.

3. The method of claim 2 wherein the immunoglobulin heavy chain constant region is an F_c fragment.

4. The method of claim 1 wherein the inflammatory disease is a chronic inflammatory disease.

5. The method of claim 4 wherein the chronic inflammatory disease is selected from the group consisting of inflammatory bowel disease, ulcerative colitis, Crohn'"'"'s disease, atopic dermatitis, and eczema.

6. The method of claim 1 wherein the inflammatory disease is an acute inflammatory disease.

7. The method of claim 6 wherein the acute inflammatory disease is selected from the group consisting of endotoxemia, septicemia, and toxic shock syndrome.

8. The method of claim 1 wherein the heterodimeric or multimeric soluble receptor polypeptide further comprises a radionuclide, enzyme, substrate, cofactor, fluorescent marker, chemiluminescent marker, peptide tag, magnetic particle, drug, or toxin.