Diuretic Aerosols and Methods of Making and Using Them
First Claim
1. A condensation aerosol for delivery wherein the condensation aerosol is formed by heating a thin film containing a drug, to produce a vapor of the drug, and condensing the vapor to form a condensation aerosol characterized by less than 10% drug degradation products by weight, and an MMAD of less than 5 microns, and wherein the drug is selected from the group consisting of bumetanide, ethacrynic acid, furosemide, muzolimine, spironolactone, torsemide, triamterene, tripamide, BG 9928 and BG 9719.
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Abstract
Described herein are diuretic condensation aerosols and methods of making and using them. Kits for delivering a condensation aerosol are also described. The diuretic aerosols typically comprise diuretic condensation aerosol particles that comprise a diuretic compound. In some variations the diuretic compound is selected from the group consisting of bumetanide, ethacrynic acid, furosemide, muzolimine, spironolactone, torsemide, triamterene, tripamide, BG 9928, and BG 9719. Methods of treating edema using the described aerosols are also provided. In general, the methods typically comprise the step of administering a therapeutically effective amount of diuretic condensation aerosol to a person with edema. The diuretic condensation aerosol may be administered in a single inhalation, or may be administered in more than one inhalation. Methods of forming a diuretic condensation aerosol are also described. The methods typically comprise the steps of providing a diuretic composition, vaporizing the composition to form a vapor, and then condensing the diuretic composition vapor.
150 Citations
99 Claims
- 1. A condensation aerosol for delivery wherein the condensation aerosol is formed by heating a thin film containing a drug, to produce a vapor of the drug, and condensing the vapor to form a condensation aerosol characterized by less than 10% drug degradation products by weight, and an MMAD of less than 5 microns, and wherein the drug is selected from the group consisting of bumetanide, ethacrynic acid, furosemide, muzolimine, spironolactone, torsemide, triamterene, tripamide, BG 9928 and BG 9719.
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20. A method of producing a drug in an aerosol form, wherein the drug is selected from the group consisting of bumetanide, ethacrynic acid, furosemide, muzolimine, spironolactone, torsemide, triamterene, tripamide, BG 9928 and BG 9719, comprising:
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a. heating a thin film containing the drug to produce a vapor of the drug, and b. providing an air flow through the vapor to form a condensation aerosol characterized by less than 10% drug degradation products by weight, and an MMAD of less than 5 microns. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38)
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39. A method of treating edema in a patient comprising administering to the patient a therapeutic amount of a drug condensation aerosol by inhalation,
wherein the condensation aerosol is formed by heating a thin film containing the drug to produce a vapor of the drug, and condensing the vapor to form a condensation aerosol characterized by less than 10% drug degradation products by weight, and an MMAD of less than 5 microns, and wherein the drug is selected from the group consisting of bumetanide, ethacrynic acid, furosemide, muzolimine, spironolactone, torsemide, triamterene, tripamide, BG 9928 and BG 9719.
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52. A method of treating congestive heart failure in a patient comprising administering to the patient a therapeutic amount of a drug condensation aerosol by inhalation,
wherein the condensation aerosol is formed by heating a thin film containing the drug to produce a vapor of the drug, and condensing the vapor to form a condensation aerosol characterized by less than 10% drug degradation products by weight, and an MMAD of less than 5 microns, and wherein the drug is selected from the group consisting of bumetanide, ethacrynic acid, furosemide and torsemide.
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64. A method of administering to a patient by inhalation a drug condensation aerosol,
wherein the drug condensation aerosol is formed by heating a thin film containing the drug to produce a vapor of the drug, and condensing the vapor to form a condensation aerosol characterized by less than 10% drug degradation products by weight, and an MMAD of less than 5 microns, and wherein the drug is selected from the group consisting of bumetanide, ethacrynic acid, furosemide, muzolimine, spironolactone, torsemide, triamterene, tripamide, BG 9928 and BG 9719.
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75. A kit for delivering a drug condensation aerosol comprising:
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a. a thin film containing the drug, wherein the drug is selected from the group consisting of bumetanide, ethacrynic acid, furosemide, muzolimine, spironolactone, torsemide, triamterene, tripamide, BG 9928 and BG 9719, and b. a device for providing the condensation aerosol, wherein the condensation aerosol is formed by heating the thin film to produce a vapor of the drug, and condensing the vapor to form a condensation aerosol characterized by less than 10% drug degradation products by weight, and an MMAD of less than 5 microns. - View Dependent Claims (76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99)
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Specification