Ion Exchange Resin Treated to Control Swelling
First Claim
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1. A pharmaceutical composition made by the process comprising the steps of:
- loading one or more drugs in a solution onto one or more ion exchange resin particles to form a drug-loaded resin particle;
separating the drug-loaded resin particle from the solution;
drying the drug-loaded resin particle; and
recombining the drug-loaded resin particle with the solution, whereby more drugs load on the drug-loaded resin particle from the solution.
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Abstract
The present invention provides a method and composition for loading one or more drugs in a solution onto one or more ion exchange resin particles to form a drug-loaded resin particle. The drug-loaded resin particle is separated from the solution and dried before recombining the drug-loaded resin particle with the solution to load more drugs onto the drug-loaded resin particle from the solution.
62 Citations
24 Claims
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1. A pharmaceutical composition made by the process comprising the steps of:
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loading one or more drugs in a solution onto one or more ion exchange resin particles to form a drug-loaded resin particle;
separating the drug-loaded resin particle from the solution;
drying the drug-loaded resin particle; and
recombining the drug-loaded resin particle with the solution, whereby more drugs load on the drug-loaded resin particle from the solution. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method of preparing a drug-resin compound comprising the steps of:
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loading in a solution one or more drugs onto one or more ion exchange resin particles to form a drug-loaded resin particle;
separating the drug-loaded resin particle from the solution;
drying the drug-loaded resin particle; and
recombining the drug-loaded resin particle with the solution, whereby more drugs are loaded onto the drug-loaded resin particle from the solution. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. A method of making a pharmaceutical composition comprising the steps of:
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loading in a solution one or more substances onto one or more cationic exchange resin particles to form a loaded resin particle;
adding one or more sugar alcohols to the solution, wherein the one or more sugar alcohols comprise between about 0.01% to about 10% by weight;
separating the loaded resin particle from the solution;
drying the solid phase; and
recombining the solution with the drug-loaded resin particle, whereby more drugs are loaded onto the drug-loaded resin particle. - View Dependent Claims (24)
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Specification