Composition and procedure for tissue creation, regeneration and repair by a cell-bearing biological implant enriched with platelet concentrate and supplements
First Claim
1. A method for biological tissue repair in a recipient, comprising the steps of:
- extracting an Extremely Platelet Rich Plasma (EPRP) from whole blood;
activating coagulation of the Extremely Platelet Rich Plasma (EPRP) by the addition of Calcium;
wherein the activation is carried out in an environment free of exogenous thrombin; and
placing at least a portion of the activated Extremely Platelet Rich Plasma (EPRP) at a biological site of the intended recipient.
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Accused Products
Abstract
A composition and method for enhancing tissue growth, regeneration, and repair includes a Biological Glue formed by extraction of an Extremely Platelet Rich Plasma (EPRP) derived from whole blood, and subsequent activation and clotting. The Biological Glue may be utilized alone to fill defects or may be used as an adhesive agent for other biological and non-biological materials. These materials may include processed thrombus derived from the activation of EPRP. Additionally, the Extremely Platelet Rich Plasma may be impregnated with directly harvested or cultured cells, including stem cells, or other materials, prior to activation, to form a Biological Implant that may be implanted in vivo. A Platelet Factor Enriched Serum (PFS) derived from the activation of the Extremely Platelet Rich Plasma (EPRP) may be added to the cell cultures in preparation of a Biological Implant, in order to provide additional growth factors that speed the development of the cell cultures.
41 Citations
53 Claims
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1. A method for biological tissue repair in a recipient, comprising the steps of:
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extracting an Extremely Platelet Rich Plasma (EPRP) from whole blood;
activating coagulation of the Extremely Platelet Rich Plasma (EPRP) by the addition of Calcium;
wherein the activation is carried out in an environment free of exogenous thrombin; and
placing at least a portion of the activated Extremely Platelet Rich Plasma (EPRP) at a biological site of the intended recipient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51)
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52. A method for biological tissue repair in a recipient, comprising the steps of:
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extracting an Extremely Platelet Rich Plasma (EPRP) from whole blood;
activating coagulation of the Extremely Platelet Rich Plasma (EPRP) to form a Biological Glue; and
placing at least a portion of the Biological Glue at a biological site of the intended recipient to adhere at least one material at the biological site of the intended implant recipient.
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53. A method for biological tissue repair in a recipient, comprising the steps of:
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extracting an Extremely Platelet Rich Plasma (EPRP) from whole blood;
adding a material to the Extremely Platelet Rich Plasma (EPRP) to substantially disperse the material throughout the Extremely Platelet Rich Plasma (EPRP);
activating coagulation of the Extremely Platelet Rich Plasma (EPRP) to form a Biological Implant; and
placing at least a portion of the Biological Implant at a biological site of the intended recipient to at least partially occupy a space.
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Specification