HYDROPHOBIC CORE CARRIER COMPOSITIONS FOR DELIVERY OF THERAPEUTIC AGENTS, METHODS OF MAKING AND USING THE SAME
First Claim
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1. A composition comprising (i) a carrier;
- (ii) a plurality of first hydrophobic groups, wherein the first hydrophobic group is covalently linked to the carrier, is capable of binding a load molecule, and has a molecular weight of less than about 1,000 Daltons independent of the carrier weight; and
(iii) a plurality of first protective side chains, wherein each first protective side chain is covalently linked to the carrier and has a molecular weight between about 400 and 20,000 Daltons independent of the carrier weight.
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Abstract
The present invention relates, in part, to a biocompatible hydrophobic-core carrier comprising a carrier, and a plurality of hydrophobic groups covalently linked to the polymeric carrier. The hydrophobic groups are capable of dissociably linking load molecules such as therapeutic agents. The hydrophobic-core carrier may also comprise protective side chains, orienting molecules, and targeting molecules.
114 Citations
90 Claims
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1. A composition comprising (i) a carrier;
- (ii) a plurality of first hydrophobic groups, wherein the first hydrophobic group is covalently linked to the carrier, is capable of binding a load molecule, and has a molecular weight of less than about 1,000 Daltons independent of the carrier weight; and
(iii) a plurality of first protective side chains, wherein each first protective side chain is covalently linked to the carrier and has a molecular weight between about 400 and 20,000 Daltons independent of the carrier weight. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90)
- (ii) a plurality of first hydrophobic groups, wherein the first hydrophobic group is covalently linked to the carrier, is capable of binding a load molecule, and has a molecular weight of less than about 1,000 Daltons independent of the carrier weight; and
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33. A composition, comprising:
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(i) a carrier; and
(ii) a plurality of first hydrophobic groups with a covalently linked protective side chain, wherein the first hydrophobic group has a first end that is covalently linked to the carrier and a second end that is covalently linked to the protective side chain;
wherein the first hydrophobic group has a molecular weight between 150 to 1000 Daltons independent of the carrier and protective side chain weights; and
wherein the protective side chain has a molecular weight between about 400 and 20,000 Daltons independent of the carrier and hydrophobic group weights. - View Dependent Claims (34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64)
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65. A composition comprising:
- (i) a polymeric carrier selected from the group consisting of polylysine, polyaspartic acid, polyglutamic acid, polyserine, polythreonine, polycysteine, polyglycerol, polyethyleneimines, natural saccharides, aminated polysaccharides, aminated oligosaccharides, polyamidoamine, polyacrylic acids, polyalcohols, sulfonated polysaccharides, sulfonated oligosaccharides, carboxylated polysaccharides, carboxylated oligosaccharides, aminocarboxylated polysaccharides, aminocarboxylated oligosaccharides, carboxymethylated polysaccharides, and carboxymethylated oligosaccharides; and
(ii) a plurality of hydrophobic groups capable of binding a load molecule and covalently linked to the carrier, wherein each hydrophobic group has a molecular weight of less than 1,000 Daltons independent of the carrier weight, and wherein each hydrophobic group is independently selected from the group consisting of a linear alkyl, branched alkyl, phenyl, naphthyl, cholesterol, vitamin D, and vitamin E. - View Dependent Claims (66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78)
- (i) a polymeric carrier selected from the group consisting of polylysine, polyaspartic acid, polyglutamic acid, polyserine, polythreonine, polycysteine, polyglycerol, polyethyleneimines, natural saccharides, aminated polysaccharides, aminated oligosaccharides, polyamidoamine, polyacrylic acids, polyalcohols, sulfonated polysaccharides, sulfonated oligosaccharides, carboxylated polysaccharides, carboxylated oligosaccharides, aminocarboxylated polysaccharides, aminocarboxylated oligosaccharides, carboxymethylated polysaccharides, and carboxymethylated oligosaccharides; and
Specification