Novel nanocomposites and their application as monolith columns
First Claim
1. A hybrid inorganic/organic material comprising a polymerized scaffolding nanocomposite (PSN), wherein the nanocomposite contains a scaffolding functionality capable of chemically interacting with a surface of a second material.
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Accused Products
Abstract
Novel materials for chromatographic separations, processes for their preparation, and separation devices containing the chromatographic materials. In particular, hybrid inorganic/organic monolith materials comprising a polymerized scaffolding nanocomposite (PSN), wherein the nanocomposite contains a scaffolding functionality capable of chemically interacting with a surface of a second material are described. The hybrid inorganic/organic materials have enhanced wall adhesion and increased resistance to shrinkage as compared to prior art monolith materials. The improved adhesion of the monoliths enable the preparation of capillary columns with an internal diameter (I.D.) ≧50 μm.
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Citations
251 Claims
- 1. A hybrid inorganic/organic material comprising a polymerized scaffolding nanocomposite (PSN), wherein the nanocomposite contains a scaffolding functionality capable of chemically interacting with a surface of a second material.
- 52. A hybrid inorganic/organic monolith comprising a polymerized scaffolding nanocomposite (PSN), wherein the nanocomposite contains a scaffolding functionality capable of chemically interacting with a surface of a second material.
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53-105. -105. (canceled)
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108-181. -181. (canceled)
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182. A separations device comprising
a) a surface capable of accepting a monolith material comprising a polymerized scaffolding nanocomposite (PSN) material, said surface comprising an anchoring functionality and b) a hybrid inorganic/organic monolith comprising a polymerized scaffolding nanocomposite (PSN), wherein the nanocomposite contains a scaffolding functionality capable of chemically interacting with the anchoring functionality on said surface, and wherein said hybrid organic/inorganic monolith is anchored to said surface by a chemical interaction between said scaffolding functionality and anchoring functionality.
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184-193. -193. (canceled)
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196-245. -245. (canceled)
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246. A method of in situ preparation of a hybrid inorganic/organic monolith in a fused-silica capillary column, said method comprising:
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forming an anchoring functionality on an interior surface of said capillary column; and
forming inside said capillary column a hybrid inorganic/organic monolith comprising a polymerized scaffolding nanocomposite (PSN), wherein the nanocomposite contains a scaffolding functionality capable of chemically interacting with the anchoring functionality on said surface, said monolith being formed by;
a) forming a sol-gel by the reaction of two or more monomers;
b) initiating a polymerization reaction; and
c) allowing the monomers to react through a polymerization sol-gel (PSG) reaction;
whereby said scaffolding functionality and said anchoring functionality chemically interact to thereby anchor said monolith to said surface, such that a hybrid inorganic/organic monolith is prepared in situ in the fused-silica capillary column. - View Dependent Claims (247)
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Specification