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Thrombopoietic compounds

  • US 20070142295A1
  • Filed: 12/22/2006
  • Published: 06/21/2007
  • Est. Priority Date: 10/23/1998
  • Status: Abandoned Application
First Claim
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1. A TMP compound that binds to an mp1 receptor comprising the core structure:


  • X2

    X3

    X4

    X5

    X6

    X7

    X8

    X9

    X10, wherein, X2 is selected from the group consisting of Glu, Asp, Lys, and Val;

    X3 is selected from the group consisting of Gly and Ala;

    X4 is Pro;

    X5 is selected from the group consisting of Thr and Ser;

    X6 is selected from the group consisting of Leu, Ile, Val, Ala, and Phe;

    X7 is selected from the group consisting of Arg and Lys;

    X8 is selected from the group consisting of Gln, Asn, and Glu;

    X9 is selected from the group consisting of Trp, Tyr, Cys, Ala, and Phe;

    X10 is selected from the group consisting of Leu, Ile, Val, Ala, Phe, Met, and Lys; and

    wherein any of X2, X3, X4, X5, X6, X7, X8, X9, and X10 is a non-naturally occurring amino acid; and

    physiologically acceptable salts thereof.

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