Noninvasive measurement of chemical substances

• US 20070142718A1
• Filed: 11/20/2006
• Published: 06/21/2007
• Est. Priority Date: 09/04/1996
• Status: Active Grant

• Current Assignee: Geelux Holdings, Ltd.
• Original Assignee: Marcio Abreu
• Inventors: Abreu, Marcio
• Granted Patent: US 7,654,957 B2
• Time in Patent Office: Days
• US Class Current: 600/323
• CPC Class Codes: A61B 2560/0214 of power generation or supply
• CPC Class Codes: A61B 2560/0219 of externally powered implanted units
• CPC Class Codes: A61B 2560/0252 using ambient temperature
• CPC Class Codes: A61B 2560/0418 Pen-shaped housings
• CPC Class Codes: A61B 2562/0238 Optical sensor arrangements for performing transmission measurements on body tissue
• CPC Class Codes: A61B 2562/12 Manufacturing methods specially adapted for producing sensors for in-vivo measurements
• CPC Class Codes: A61B 3/0025 characterised by electronic signal processing, e.g. eye models
• CPC Class Codes: A61B 3/0058 for multiple images
• CPC Class Codes: A61B 3/10 Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
• CPC Class Codes: A61B 3/1241 specially adapted for observation of ocular blood flow, e.g. by fluorescein angiography
• CPC Class Codes: A61B 3/14 Arrangements specially adapted for eye photography apparatus or arrangements for taking photographs per se G03B
• CPC Class Codes: A61B 3/16 for measuring intraocular pressure, e.g. tonometers
• CPC Class Codes: A61B 3/185 characterised by modular construction
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/01 Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/031 Intracranial pressure
• CPC Class Codes: A61B 5/14507 specially adapted for measuring characteristics of body fluids other than blood devices for taking samples of body liquids A61B10/0045
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14539 for measuring pH
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1455 : using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/14555 : specially adapted for the eye fundus
• CPC Class Codes: A61B 5/1486 : using enzyme electrodes, e.g. with immobilised oxidase
• CPC Class Codes: A61B 5/18 : for vehicle drivers or machine operators
• CPC Class Codes: A61B 5/412 : Detecting or monitoring sepsis
• CPC Class Codes: A61B 5/416 : the spleen
• CPC Class Codes: A61B 5/445 : Evaluating skin irritation or skin trauma, e.g. rash, eczema, wound, bed sore
• CPC Class Codes: A61B 5/4839 : combined with drug delivery
• CPC Class Codes: A61B 5/6814 : Head
• CPC Class Codes: A61B 8/06 : Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00
• CPC Class Codes: A61B 8/56 : Details of data transmission or power supply
• CPC Class Codes: A61F 9/0017 : implantable in, or in contact with, the eye, e.g. ocular inserts
• CPC Class Codes: A61F 9/0026 : Ophthalmic product dispenser attachments to facilitate positioning near the eye
• CPC Class Codes: A61P 27/02 : Ophthalmic agents
• CPC Class Codes: A61P 27/06 : Antiglaucoma agents or miotics
• CPC Class Codes: A61P 35/00 : Antineoplastic agents
• CPC Class Codes: A61P 9/00 : Drugs for disorders of the cardiovascular system
• CPC Class Codes: G02C 11/10 : Electronic devices other than hearing aids
• CPC Class Codes: G02C 7/04 : Contact lenses for the eyes disinfection or sterilisation of contact lenses A61L12/00
• CPC Class Codes: Y02A 90/10 : Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

Utilization of a contact device placed on the eye in order to detect physical and chemical parameters of the body as well as the non-invasive delivery of compounds according to these physical and chemical parameters, with signals being transmitted continuously as electromagnetic waves, radio waves, infrared and the like. One of the parameters to be detected includes non-invasive blood analysis utilizing chemical changes and chemical products that are found in the conjunctiva and in the tear film. A transensor mounted in the contact device laying on the cornea or the surface of the eye is capable of evaluating and measuring physical and chemical parameters in the eye including non-invasive blood analysis. The system utilizes eye lid motion and/or closure of the eye lid to activate a microminiature radio frequency sensitive transensor mounted in the contact device. The signal can be communicated by wires or radio telemetered to an externally placed receiver. The signal can then be processed, analyzed and stored. Several parameters can be detected including a complete non-invasive analysis of blood components, measurement of systemic and ocular blood flow, measurement of heart rate and respiratory rate, tracking operations, detection of ovulation, detection of radiation and drug effects, diagnosis of ocular and systemic disorders and the like.

Claims

1-58. -58. (canceled)

59. An ophthalmic system comprising:

a tonometer for measuring intraocular pressure;

a pachymetry apparatus for measuring corneal thickness;

an electrical device altering the measured intraocular pressure based upon the measured corneal thickness to produce a corrected intraocular pressure; and

a display identifying the corrected intraocular pressure.

60. The ophthalmic system according to claim 59, further comprising at least one of a keratometer for measuring corneal curvature, a biometer for measuring size of the eye and a device for measuring ocular rigidity.

61. The ophthalmic system according to claim 59, wherein the electrical device is a processor.

62. The ophthalmic system according to claim 59, further comprising a memory device.

63. An ophthalmic system comprising:

a tonometer for measuring intraocular pressure;

at least one of a keratometer for measuring corneal curvature, a biometer for measuring size of the eye and a device for measuring ocular rigidity;

an electrical device altering the measured intraocular pressure based upon the at least one of the measured cornered curvature, the measured size of the eye and the measured ocular rigidity to produce a corrected intraocular pressure; and

a display identifying the corrected intraocular pressure.

64. The ophthalmic system according to claim 63, further comprising a memory device.

65. The ophthalmic system according to claim 63, wherein the electrical device is a processor.

66. An ophthalmic system for determining an intraocular pressure correction signal or value comprising:

a pachymetry apparatus for measuring corneal thickness; and

an electrical device for calculating an intraocular pressure correction signal or value based on a deviation of said measured corneal thickness from a normal corneal thickness.

67. The ophthalmic system according to claim 66, further comprising a device for measuring intraocular pressure, the intraocular pressure correction signal or value is applied to the measured intraocular pressure to produce a corrected intraocular pressure.

68. The ophthalmic system according to claim 67, wherein the electrical device is a processor applying the intraocular pressure correction signal or value to the measured intraocular pressure.

69. The ophthalmic system according to claim 68, further comprising at least one of a memory device and a recording device.

70. The ophthalmic system according to claim 66, further comprising at least one of a keratometer for measuring corneal curvature, a biometer for measuring size of the eye and a device for measuring ocular rigidity.

71. The ophthalmic system according to claim 68, wherein the processor has access to lookup tables.

72. The ophthalmic system according to claim 66, further comprising a display identifying the intraocular correction signal.

73. An ophthalmic system for determining a corrected intraocular pressure value, said ophthalmic system comprising:

a device for measuring an intraocular pressure;

a pachymetry apparatus for measuring corneal thickness;

an electrical device for adjusting said intraocular pressure value based on said corneal thickness to generate said corrected intraocular pressure value; and

a display identifying the corrected intraocular pressure.

74. The ophthalmic system according to claim 73, wherein the electrical device is a processor.

75. The ophthalmic system according to claim 74, further comprising at least one of a memory device and a recording device.

76. The ophthalmic system according to claim 73, further comprising at least one of a keratometer for measuring corneal curvature, a biometer for measuring size of the eye and a device for measuring ocular rigidity.

77. The ophthalmic system according to claim 74, wherein the processor has access to lookup tables.

78. A method for determining an intraocular pressure correction value, said method comprising the steps of

measuring corneal thickness value with a pachymetry apparatus;

determining an intraocular pressure correction value using an electrical circuit based on a deviation of said measured corneal thickness value from normal corneal thickness; and

reporting said intraocular pressure correction value.

79. The method according to claim 78, further including the step of determining deviation from normal corneal thickness once the corneal thickness is measured by said pachymetry apparatus.

80. The method according to claim 78, further including the step of measuring at least one of corneal curvature, size of the eye and ocular rigidity.

81. The method according to claim 78, wherein said determining step further comprises using a processor.

82. The method according to claim 81, wherein the processor accesses lookup tables.

83. A method for determining a corrected intraocular pressure value, said method comprising the steps of

measuring an intraocular pressure value;

measuring a corneal thickness value;

adjusting said intraocular pressure value based on said corneal thickness value using an electrical circuit to generate said corrected intraocular pressure value; and

reporting said intraocular pressure correction value.

84. The method according to claim 83, further including the step of determining deviation from normal corneal thickness of said measured corneal thickness.

85. The method according to claim 83, wherein said determining step further comprises using a processor.

86. The method according to claim 83, further including the step of measuring at least one of corneal curvature, size of the eye and ocular rigidity.

87. The method according to claim 83, wherein the processor accesses lookup tables.

88. A method for determining an intraocular pressure correction value, said method comprising the steps of

measuring at least one of corneal thickness, corneal curvature, size of the eye and ocular rigidity;

determining an intraocular pressure correction value using an electrical circuit based on a deviation of said at least one of corneal thickness, corneal curvature, size of the eye and ocular rigidity from a normal value; and

reporting said intraocular pressure correction value.

89. A method for determining corrected intraocular pressure, said method comprising the steps of

measuring an intraocular pressure value;

measuring at least one of corneal thickness, corneal curvature, size of the eye and ocular rigidity;

adjusting said intraocular pressure value based on said at least one of corneal thickness, corneal curvature, size of the eye and ocular rigidity;

using an electrical circuit to generate said corrected intraocular pressure value; and

reporting said intraocular pressure correction value.