Apparatus and methods for mitigating the effects of foreign interferents on analyte measurements in spectroscopy
First Claim
1. ) A method for determining an analyte property in a biological subject, comprising:
- a) Determining a spectrum, comprising information related to the response of a portion of the subject to incident radiation;
b) Determining from the spectrum whether an interferent affected the spectrum (an “
interferent condition”
), and, if so, performing an interferent mitigation action;
c) Determining the analyte property in the biological subject after the interferent mitigation action.
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Accused Products
Abstract
The present invention includes apparatuses and methods for mitigating the effects of foreign interferents on analyte measurements. The present invention comprises several interferent mitigation steps. Examples include sample cleaning procedures, detection of the presence of interferents, determination of the identity of interferents, and modification or selection of a multivariate calibration model to mitigate the effects of one or more interferents on analyte measurements. The interferent mitigation steps of the present invention can be applied individually, and in some embodiments can be applied in combination. Some examples of relevant analyte measurements include the noninvasive determination of the presence or concentration of alcohol, glucose, urea, byproducts of alcohol metabolism, and substances of abuse.
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Citations
25 Claims
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1. ) A method for determining an analyte property in a biological subject, comprising:
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a) Determining a spectrum, comprising information related to the response of a portion of the subject to incident radiation;
b) Determining from the spectrum whether an interferent affected the spectrum (an “
interferent condition”
), and, if so, performing an interferent mitigation action;
c) Determining the analyte property in the biological subject after the interferent mitigation action. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. ) A method of determining an analyte property in a biological subject, comprising:
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a) Determining a spectrum of a portion of the subject, where the spectrum comprises information regarding the response at a plurality of wavelengths of the portion of the subject to incident radiation;
b) Determining from the spectrum whether an interferent is present, where an interferent is any substance or condition that unacceptably compromises the quality of the determination of the characteristic;
c) If there is no interferent present, then determining the analyte property from the spectrum. - View Dependent Claims (13, 14, 15, 16)
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17. ) A method of determining an analyte property in a biological subject, comprising:
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a) Determining a spectrum of a portion of the subject, where the spectrum comprises information regarding the response at a plurality of wavelengths of the portion of the subject to incident radiation;
b) Determining from the spectrum whether an interferent is present, where an interferent is any substance or condition that unacceptably compromises the quality of the determination of the property;
c) If an interferent is present, then classifying the interferent from the spectrum;
d) Selecting a method of determining the analyte property from the determination of the presence of an interferent and from the classification of the interferent;
e) Determining the analyte property from the spectrum and from the selected method. - View Dependent Claims (18, 19, 20, 23, 24, 25)
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- 21. ) A method as in claim 21, wherein the multivariate model resistant to the effect of the classified interferent comprises a multivariate model modified using orthogonal signal correction.
Specification