Monitoring of physiological analytes
First Claim
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1. A monitoring system for measuring an amount or concentration of an analyte present in one or more samples in a biological system, the monitoring system comprising:
- a sampling device for providing one or more samples comprising said analyte, wherein said sampling device comprises one or more microneedles or microfine cannulas;
a sensing device adapted to obtain a measurement signal from the analyte in each of said samples, said measurement signal specifically related to the analyte amount or concentration in the biological system; and
one or microprocessors in operative communication with said sensing device, wherein said one or more microprocessors comprise programming to control (i) operating said sensing device to provide said measurement signals, (ii) applying one or more processes for selectively favoring analyte-specific signal components over other signal components due to interfering species, said processes selected from the group consisting of (a) a differential signal process which subtracts non-analyte signal components from the measurement signal, (b) a selective detection process which is performed during sensing, (c) a purge step that is performed before and/or after said obtaining, wherein said purge step substantially removes residual signal components from the sensing device, and (d) any combinations thereof, and (iii) repeating steps (i) and (ii) at least once over time.
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Abstract
Methods and devices are provided for measuring the concentration of target chemical analytes present in a biological system. Device configuration and/or measurement techniques are employed in order to reduce the effect of interfering species on sensor sensitivity. One important application of the invention involves a method and device for monitoring blood glucose values.
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Citations
18 Claims
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1. A monitoring system for measuring an amount or concentration of an analyte present in one or more samples in a biological system, the monitoring system comprising:
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a sampling device for providing one or more samples comprising said analyte, wherein said sampling device comprises one or more microneedles or microfine cannulas;
a sensing device adapted to obtain a measurement signal from the analyte in each of said samples, said measurement signal specifically related to the analyte amount or concentration in the biological system; and
one or microprocessors in operative communication with said sensing device, wherein said one or more microprocessors comprise programming to control (i) operating said sensing device to provide said measurement signals, (ii) applying one or more processes for selectively favoring analyte-specific signal components over other signal components due to interfering species, said processes selected from the group consisting of (a) a differential signal process which subtracts non-analyte signal components from the measurement signal, (b) a selective detection process which is performed during sensing, (c) a purge step that is performed before and/or after said obtaining, wherein said purge step substantially removes residual signal components from the sensing device, and (d) any combinations thereof, and (iii) repeating steps (i) and (ii) at least once over time. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A monitoring system for measuring an amount or concentration of an analyte present in one or more samples in a biological system, the monitoring system comprising:
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a sampling device for providing one or more samples comprising said analyte, wherein said samples are provided using iontophoresis;
a sensing device adapted to obtain a measurement signal from the analyte in each of said samples, said measurement signal specifically related to the analyte amount or concentration in the biological system; and
one or microprocessors in operative communication with said sensing device, wherein said one or more microprocessors comprise programming to control (i) operating said sampling device (ii) operating said sensing device to provide said measurement signals, (iii) applying one or more processes for selectively favoring analyte-specific signal components over other signal components due to interfering species, said processes selected from the group consisting of (a) a differential signal process which subtracts non-analyte signal components from the measurement signal, (b) a selective detection process which is performed during sensing, (c) a purge step that is performed before and/or after said obtaining, wherein said purge step substantially removes residual signal components from the sensing device, and (d) any combinations thereof, and (iv) repeating steps (i) through (iii) at least once over time. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15)
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16. A method for measuring an amount or concentration of an analyte present in one or more samples in a biological system, the method comprising:
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pre-treating a sample site to enhance permeability of the sample site;
providing one or more samples comprising said analyte from the sample site, wherein said samples are provided using iontophoresis;
sensing each of said one or more samples with a sensor device;
obtaining respective measurement signals from the analyte in each of said samples based on said sensing, said measurement signals specifically related to the analyte amount or concentration in the biological system; and
providing one or microprocessors in operative communication with said sensor device, wherein said one or more microprocessors comprise programming to control (i) operating said sensing device to provide said measurement signals, (ii) applying one or more processes for selectively favoring analyte-specific signal components over other signal components due to interfering species, said processes selected from the group consisting of (a) a differential signal process which subtracts non-analyte signal components from the measurement signal, (b) a selective detection process which is performed during the sensing, (c) a purge performed before and/or after said obtaining, wherein said purge substantially removes residual signal components from the sensor device, and (d) any combinations thereof, and (iii) repeating steps (i) and (ii) at least once over time. - View Dependent Claims (17, 18)
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Specification