Carbodiimide crosslinking of functionalized polyethylene glycols
First Claim
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1. A synthetic absorbable macromer composition comprising:
- an acid-functional polymer of formula (I);
where R1 can be the same or different at each location and is selected from the group consisting of hydrogen, polyalkylene oxides, polyethylene glycols having degradable linkages, and polyethylene oxide-polypropylene oxide copolymers;
an amine-functional polymer selected from the group consisting of polyalkylene oxides having at least one pendant amine group and polyamino acids having at least one pendant amine group; and
a coupling agent.
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Abstract
A synthetic composition is provided which includes an acid-functional polymer having at least one pendant acid group, an amine-functional polymer having at least one pendant amine group, and a coupling agent. The synthetic composition can be used in human and animal medical applications as an adhesive or sealant.
120 Citations
28 Claims
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1. A synthetic absorbable macromer composition comprising:
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an acid-functional polymer of formula (I);
where R1 can be the same or different at each location and is selected from the group consisting of hydrogen, polyalkylene oxides, polyethylene glycols having degradable linkages, and polyethylene oxide-polypropylene oxide copolymers;
an amine-functional polymer selected from the group consisting of polyalkylene oxides having at least one pendant amine group and polyamino acids having at least one pendant amine group; and
a coupling agent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. A synthetic absorbable macromer composition comprising:
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a polyamino acid having at least one pendant acid group selected from the group consisting of polyglutamic acid and polyaspartic acid;
an amine-functional polymer selected from the group consisting of polyalkylene oxides having at least one pendant amine group and polyamino acids having at least one pendant amine group; and
a coupling agent. - View Dependent Claims (28)
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Specification