Containment of a treatment agent in a body vessel

• US 20070148243A1
• Filed: 12/21/2006
• Published: 06/28/2007
• Est. Priority Date: 12/22/2005
• Status: Abandoned Application

• Current Assignee: Cook Incorporated (Cook Group Incorporated)
• Original Assignee: Cook Incorporated (Cook Group Incorporated)
• Inventors: Bates, Brian
• Application Number:
  US11/643,354
• Publication Number:
  US 20070148243A1
• Time in Patent Office: Days
• US Class Current: 424/484
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61L 2300/00 Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61L 31/18 Materials at least partially X-ray or laser opaque

Abstract

Medical devices useful for the containment of a treatment agent in a body vessel are described. The medical devices comprise a compressible plug having compressed and uncompressed diameters. Upon delivery to a treatment site in a body vessel, the compressible plug expands to engage the interior wall of the body vessel and provides a barrier that impedes fluid flow. The presence of the barrier facilitates containment of a treatment agent introduced into the body vessel at or near the point at which the medical device is deployed. Kits and methods are also described.

Claims

1. A medical device for containing a treatment agent at a treatment site within a body vessel, said medical device comprising a compressible plug formed of a bioremodellable material and having compressed and uncompressed diameters, the compressible plug adapted to engage an interior wall of said body vessel upon deployment at said treatment site.

2. The medical device according to claim 1, wherein the bioremodellable material comprises an extracellular matrix material.

3. The medical device according to claim 2, wherein the extracellular matrix material comprises small intestine submucosa.

4. The medical device according to claim 1, wherein the bioremodellable material includes open cells.

5. The medical device according to claim 1, further comprising at least one radiopaque marker associated with the compressible plug.

6. The medical device according to claim 1, wherein the compressible plug comprises at least one barb adapted to engage the interior wall of said body vessel.

7. The medical device according to claim 6, wherein the at least one barb is integrally formed by the compressible plug.

8. The medical device according to claim 6, wherein the at least one barb comprises a separate member associated with the compressible plug.

9. The medical device according to claim 6, wherein the at least one barb is rigid.

10. The medical device according to claim 6, wherein the barb is formed of bioremodellable material.

11. The medical device according to claim 6, wherein the barb is formed of stainless steel.

12. The medical device according to claim 6, wherein one portion of the at least one barb is disposed within the thickness of the compressible plug.

13. The medical device according to claim 1, wherein the compressible plug comprises a sheet having first and second ends folded into an overlapping configuration.

14. The medical device according to claim 13, wherein the sheet comprises at least one barb adapted to engage the interior wall of said body vessel.

15. The medical device according to claim 14, wherein a first portion of the at least one barb is substantially adjacent the sheet.

16. The medical device according to claim 15, wherein a second portion of the at least one barb defines a point adapted to engage the interior wall of said body vessel.

17. The medical device according to claim 1, further comprising a support frame disposed adjacent the compressible plug.

18. The medical device according to claim 17, wherein the support frame is disposed about the compressible plug.

19. The medical device according to claim 17, wherein the support frame comprises a stent.

20. The medical device according to claim 1, further comprising at least one radiopaque marker associated with at least one of the compressible plug and the support frame.

21. A kit for containing a treatment agent at a treatment site within a body vessel, comprising:

a plug formed of a bioremodellable material and having compressed and uncompressed diameters, the compressible plug adapted to engage an interior wall of said body vessel upon deployment at said treatment site;

a treatment agent adapted for injection adjacent the plug at said treatment site;

a delivery device adapted to deliver the plug to the treatment site.

22. A method for sclerosing a vein, comprising:

providing a medical device comprising a plug formed of a bioremodellable material;

delivering the medical device to a point of treatment in said vein;

exposing the medical device to a body fluid within said vein;

contacting the medical device to the body fluid;

allowing the medical device to expand and engage an interior wall of said body vessel;

introducing a sclerosing agent into said body vessel adjacent the medical device.