COMPOSITE MICROARRAY SLIDES
First Claim
1. A composite microarray slide, useful for carrying a microarray of biological polymers comprising:
- a microporous membrane formed by a phase inversion process;
a non-porous substrate; and
an attachment layer, the attachment layer comprising at least one anchor and at least one linker, the attachment layer being operatively positioned between the microporous membrane and the non-porous substrate, the attachment layer sufficiently bonding the non-porous substrate to the microporous membrane so that when the composite microarray slide is subjected to an organic solvent system for greater than about 6 hours, the microporous membrane does not delaminate significantly from the non-porous substrate.
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Accused Products
Abstract
Improved composite microarray slides for use in micro-analytical diagnostic applications are disclosed. Specifically, composite microarray slides useful for carrying a microarray of biological polymers on the surface thereof including composite microarray slides having a porous membrane formed by a phase inversion process effectively attached by covalent bonding through chemical agents that comprise anchor/linker moieties to a substrate that prepares the substrate to sufficiently bond to the porous membrane formed by a phase inversion process such that the combination produced thereby is useful in microarray applications and wherein the composite microarray slides are covalently bonded to a solid base member, such as, for example, a glass or Mylar microscope slide, such that the combination produced thereby is useful in microarray applications. Apparatus and methods for fabricating the composite microarray slides are also disclosed.
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Citations
18 Claims
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1. A composite microarray slide, useful for carrying a microarray of biological polymers comprising:
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a microporous membrane formed by a phase inversion process;
a non-porous substrate; and
an attachment layer, the attachment layer comprising at least one anchor and at least one linker, the attachment layer being operatively positioned between the microporous membrane and the non-porous substrate, the attachment layer sufficiently bonding the non-porous substrate to the microporous membrane so that when the composite microarray slide is subjected to an organic solvent system for greater than about 6 hours, the microporous membrane does not delaminate significantly from the non-porous substrate. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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Specification