CANCER THERAPY
4 Assignments
0 Petitions
Accused Products
Abstract
The present invention relates, in general, to cancer therapy, and, in particular, to a method of preventing or treating cancer using low molecular weight antioxidants (e.g., mimetics of superoxide dismutase (SOD)) as the active agent or as a chemo- and/or radio-protectant. The invention also relates to compounds and compositions suitable for use in such a method.
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Citations
37 Claims
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1-10. -10. (canceled)
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11. A method of protecting normal tissue of a mammal from the toxic effects associated with radiotherapy comprising administering to a mammal in need thereof an amount of a mimetic of an enzymatic scavenger of reactive oxygen species sufficient to effect said treatment, said mimetic having the formula
or pharmaceutically acceptable salt thereof wherein: -
R1, R2, R3and R4 are, wherein each X is the same or different and is an alkyl, and Z is a counterion. - View Dependent Claims (14)
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12-13. -13. (canceled)
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18-32. -32. (canceled)
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33. A method of ameliorating radiation-induced normal tissue injury in a mammal comprising administering to a mammal in need thereof an amount of a mimetic of an enzymatic scavenger of reactive oxygen species sufficient to effect said ameliorating, said mimetic having the formula
or pharmaceutically acceptable salt thereof wherein: -
R1, R2, R3and R4 , are wherein each X is the same or different and is an alkyl, and Z is a counterion. - View Dependent Claims (34, 35, 36, 37)
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Specification