PH modulated films for delivery of actives
First Claim
Patent Images
1. A composition comprising:
- (a) at least one component having a non-neutral pH when combined with water; and
(b) a pH modulated polymer system selected to reduce or prevent synerisis when combined with said non-neutral component in combination with water.
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Abstract
The invention relates to pH modulated films and methods of their preparation. The film compositions include at least one component having a non-neutral pH when combined with water; and a pH modulated polymer system selected to reduce or prevent synerisis when combined with the non-neutral component in combination with aqueous media. The films demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, extrusion process, or other process that maintains the required uniformity of the film.
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Citations
89 Claims
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1. A composition comprising:
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(a) at least one component having a non-neutral pH when combined with water; and
(b) a pH modulated polymer system selected to reduce or prevent synerisis when combined with said non-neutral component in combination with water. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. A composition comprising:
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(a) a component having an acidic pH when combined with water; and
(b) a polymer system comprising at least one neutral or acidic polymer. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37)
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38. A composition comprising:
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(a) a component having a basic pH when combined with water; and
(b) a polymer system comprising at least one basic polymer. - View Dependent Claims (39, 40, 41, 42, 43)
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44. A device comprising:
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(a) a film composition comprising (i) at least one component having a non-neutral pH when combined with water; and
(ii) a pH modulated polymer system selected to reduce or prevent synerisis when combined with said non-neutral component in combination with water; and
(b) a delivery substrate. - View Dependent Claims (45, 46, 47, 48)
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49. A method of preparing a film comprising:
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(a) providing a component having a non-neutral pH when combined with water;
(b) providing a pH modulated polymer system selected to reduce or prevent synerisis when combined with said non-neutral component in combination with an aqueous solvent;
(c) combining said non-neutral component and said polymer system with an aqueous solvent to produce a film-forming composition; and
(d) forming said film-forming composition into a film. - View Dependent Claims (50, 51, 52, 53, 54, 55, 56, 57, 58)
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59. A method of topical administration of an active comprising:
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(a) providing a pH modulated film composition comprising (i) a component having a non-neutral pH when combined with water; and
(ii) a pH modulated polymer system selected to reduce or prevent synerisis when combined with said non-neutral component in combination with water; and
(b) applying said pH modulated film composition to a body surface in the presence of an active. - View Dependent Claims (60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73)
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74. A system for applying an active, comprising:
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(a) a water soluble composition in the form of a first film, said composition comprising (i) at least one component having a non-neutral pH when combined with water; and
(ii) a pH modulated polymer system selected to reduce or prevent synerisis when combined with said non-neutral component in combination with aqueous media; and
(b) an aqueous solvent for dissolving said water soluble first film, said solvent being provided for direct contact with said first film to cause said non-neutral component to be dissolved or dispersed out of said first film in the presence of an active, whereby said active can be delivered to a surface area in need thereof. - View Dependent Claims (75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89)
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Specification