Method and Apparatus for Photostimulation Enhanced Analyte Property Estimation
First Claim
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1. A method for analyte property determination at a tissue sample site of a human subject, comprising the steps of:
- generating a calibration from samples collected from well perfused tissue;
enhancing perfusion at the sample site by photostimulation at or near the sample site with a first photon source;
noninvasively measuring a spectrum from the sample site, wherein said step of measuring uses a second photon source; and
estimating said analyte property using said calibration and said spectrum, wherein said calibration generated using samples collected from well perfused sample tissue applies to said spectrum.
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Abstract
A method and apparatus using photostimulation to treat or pretreat a sample site prior to analyte property estimation is presented. More particularly, photonic-stimulation at and/or near at least one sample site is used to enhance perfusion of the sample site leading to reduced errors associated with sampling. This allows an analyte property determination in well perfused regions of the body while sampling at a more convenient less well perfused region of the body.
136 Citations
31 Claims
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1. A method for analyte property determination at a tissue sample site of a human subject, comprising the steps of:
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generating a calibration from samples collected from well perfused tissue;
enhancing perfusion at the sample site by photostimulation at or near the sample site with a first photon source;
noninvasively measuring a spectrum from the sample site, wherein said step of measuring uses a second photon source; and
estimating said analyte property using said calibration and said spectrum, wherein said calibration generated using samples collected from well perfused sample tissue applies to said spectrum. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A method for analyte property determination at a sample site of a human subject, comprising the steps of:
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enhancing perfusion at the sample site by photostimulating about the sample site;
enhancing perfusion of the sample site with a second technique, wherein said second technique is used within four hours of said photostimulating step; and
determining said analyte property with either an invasive apparatus or a noninvasive apparatus after said steps of photostimulating. - View Dependent Claims (18, 19, 20, 21, 22)
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23. A method for analyte property determination at a sample site, of a human subject comprising the steps of:
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enhancing perfusion at the sample site by photostimulating a region about the sample site;
noninvasively determining said analyte property at the sample site, wherein said determining step is performed within a period of four hours following said photostimulating step, wherein said noninvasively determining step uses at least one wavelength of incident light not used in said photostimulating step.
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24. A method for analyte property determination at a sample site of a human subject, comprising the steps of:
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enhancing perfusion at the sample site by photostimulating with a light emitting diode at or about the sample site;
noninvasively determining said analyte property at said photostimulated sample site, wherein said determining step is performed using a photon source having a total spectral range in excess of 300 nm, wherein said determining step occurs within four hours of said photostimulating step.
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25. An apparatus for analyte property determination at a tissue sample site of a human subject comprising:
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a first photon source for photostimulation at or near the sample site to enhance perfusion at the sample site; and
an analyzer comprising a calibration generated using samples collected from well perfused tissue, said analyzer comprising a second photon source, means for measuring a spectrum from the sample site, and means for estimating said analyte property using said calibration and said spectrum, wherein samples collected from well perfused sample tissue are used to generate said calibration that is applied to said spectrum. - View Dependent Claims (26, 27, 28, 29, 30, 31)
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Specification