Neural stimulator to treat sleep disordered breathing

• US 20070150006A1
• Filed: 12/28/2005
• Published: 06/28/2007
• Est. Priority Date: 12/28/2005
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Kwok, Jonathan, Lee, Kent, Libbus, Imad, Caparso, Anthony, Pu, Yachuan, Brooke, M.
• Granted Patent: US 7,672,728 B2
• Time in Patent Office: Days
• US Class Current: 607/2
• CPC Class Codes: A61N 1/3611 Respiration control stimulating respiratory organs A61N1/3601
• CPC Class Codes: A61N 1/36185 Selection of the electrode configuration

Abstract

Various aspects relate to an implantable device. Various device embodiments include at least one sensor for use in detecting sleep disordered breathing, a pulse generator adapted to deliver a first electrical signal through at least one electrode to stimulate a neural target, and a controller adapted to communicate with the at least one sensor and with the pulse generator. The controller is adapted to detect sleep disordered breathing using the at least one sensor and provide a therapy for sleep disordered breathing in response to a detected apneic event. The therapy for sleep disordered breathing is adapted to deliver the first electrical signal through the at least one electrode to induce a cough reflex to terminate the apneic event. Various embodiments stimulate a superior laryngeal nerve, various embodiments stimulate a recurrent laryngeal nerve, and various embodiments stimulate a vagus nerve. Other aspects and embodiments are provided herein.

Claims

1. An implantable device, comprising:

at least one sensor for use in detecting sleep disordered breathing;

a pulse generator adapted to deliver a first electrical signal through at least one electrode to stimulate a neural target; and

a controller adapted to communicate with the at least one sensor and with the pulse generator, the controller being adapted to detect sleep disordered breathing using the at least one sensor and provide a therapy for sleep disordered breathing in response to a detected apneic event, the therapy for sleep disordered breathing being adapted to deliver the first electrical signal through the at least one electrode to induce a cough reflex to terminate the apneic event.

2. The device of claim 1, wherein the neural target includes an autonomic neural target.

3. The device of claim 2, wherein the autonomic neural target includes a superior laryngeal nerve.

4. The device of claim 2, wherein the autonomic neural target includes a recurrent laryngeal nerve.

5. The device of claim 2, wherein the autonomic neural target includes a vagus nerve.

6. The device of claim 1, wherein the at least one electrode includes at least one nerve cuff electrode.

7. The device of claim 6, wherein the at least one nerve cuff electrode includes a selective nerve stimulation electrode adapted to selectively stimulate some nerve fibres of a nerve trunk without stimulating other nerve fibres of the nerve trunk.

8. The device of claim 1, wherein the at least one electrode includes at least one electrode adapted to be intravascularly placed to transvascularly stimulate the neural target.

9. The device of claim 8, wherein the at least one electrode adapted to be intravascularly placed includes an electrode to selectively stimulate some nerve fibres of a nerve trunk without stimulating other nerve fibres of the nerve trunk.

10. The device of claim 1, wherein the pulse generator is adapted to deliver the first electrical signal through at least one electrode via a lead connecting the pulse generator to the at least one electrode.

11. The device of claim 1, wherein the pulse generator is adapted to wirelessly deliver the first electrical signal through at least one electrode.

12. The device of claim 1, further comprising at least one sleep input for use in determining when a patient is asleep, the controller being adapted to determine when the patient is sleeping using the at least one sleep input and initiate a process to detect sleep disordered breathing when the patient is asleep.

13. The device of claim 1, further comprising at least one cough sensor for use in detecting a cough level induced by the therapy for sleep disordered breathing, the controller being adapted to detect the cough level induced by the therapy for sleep disordered breathing using the at least one cough sensor, compare the detected cough level to a desired cough level, and adjust neural stimulation parameters associated with the therapy for sleep disordered breathing to induce a cough level closer to the desired cough level.

14. The device of claim 1, further comprising at least one input for use in determining whether the therapy for sleep disordered breathing has causes patient to awaken, the controller being adapted to adjust neural stimulation parameters associated with the therapy for sleep disordered breathing to prevent the stimulation for awakening the patient.

15. The device of claim 1, further comprising stopping the therapy for sleep disordered breathing when the controller and the at least one sensor for use in detecting sleep disordered breathing determines that the sleep disordered event has been terminated.

16. The device of claim 15, wherein the at least one sensor for use in detecting sleep disordered breathing includes a transthoracic sensor.

17. The device of claim 1, wherein the implantable device is incorporated in an advanced patient management (APM) system, the APM system including a portable external device adapted to communicate with the implantable device, wherein at least one of the implantable device and the portable external device is adapted to trend data associated with the implantable medical device.

18. The device of claim 1, further comprising circuitry to sense cardiac activity and deliver a second electrical signal through at least one cardiac rhythm management (CRM) electrode based on the sensed cardiac activity to provide CRM therapy.

19. The device of claim 18, wherein the CRM therapy includes a pacing therapy.

20. The device of claim 19, wherein the pacing therapy includes atrial overdrive pacing.

21. The device of claim 19, wherein the pacing therapy includes neural stimulation delivered to a neural target to regulate heart rate.

22. The device of claim 18, wherein the CRM therapy includes a defibrillation therapy.

23. The device of claim 18, wherein the CRM therapy includes a cardiac resynchronization therapy (CRT).

24. The device of claim 23, wherein the CRT therapy includes neural stimulation delivered to a baroreflex neural target for an anti-remodeling therapy (ART).

25. A device, comprising:

means for detecting a sleep disordered event; and

means for stimulating an autonomic neural target in response to a detected sleep disordered event to induce a cough to terminate the sleep disordered event.

26. The device of claim 25, comprising:

means for identifying a sleep event; and

means for initiating a process in response to the sleep event to detect the sleep disordered event.

27. The device of claim 25, further comprising:

means for detecting a cough level induced by the stimulation of the autonomic neural target; and

means for adjusting stimulation parameters for the autonomic neural target based on a detected cough level.

28. The device of claim 25, further comprising:

means for determining patient wakefulness; and

means for adjusting stimulation parameters for the autonomic neural target to prevent awakening the patient.

29. The device of claim 25, wherein the means for stimulating the autonomic neural target includes means for stimulating a superior laryngeal nerve.

30. The device of claim 25, wherein the means for stimulating the autonomic neural target includes means for stimulating a recurrent laryngeal nerve.

31. The device of claim 25, wherein the means for stimulating the autonomic neural target includes means for stimulating a vagus nerve.

32. The device of claim 25, wherein the means for stimulating an autonomic neural target includes means for selectively stimulating nerve fibres of a nerve trunk without stimulating other nerve fibres of the nerve trunk.

33. A method, comprising:

detecting a sleep disordered event; and

in response to a detected sleep disordered event, stimulating an autonomic neural target to induce a cough to terminate the sleep disordered event.

34. The method of claim 33, further comprising determining that the sleep disordered event terminated, and stopping stimulation of the neural target in response to the terminated sleep disordered event.

35. The method of claim 33, further comprising:

identifying a sleep event; and

in response to identifying the sleep event, initiating a process to detect the sleep disordered event.

36. The method of claim 33, further comprising:

detecting a cough level induced by the stimulation of the autonomic neural target; and

adjusting stimulation parameters for the autonomic neural target based on a detected cough level.

37. The method of claim 33, further comprising:

determining patient wakefulness; and

adjusting stimulation parameters for the neural target to prevent awakening the patient.

38. The method of claim 33, wherein the neural target includes a superior laryngeal nerve.

39. The method of claim 33, wherein the neural target includes a recurrent laryngeal nerve.

40. The method of claim 33, wherein the neural target includes a vagus nerve.

41. The method of claim 33, wherein the neural target includes an autonomic neural target.

42. The method of claim 33, wherein stimulating an autonomic neural target includes selectively stimulating nerve fibres of a nerve trunk without stimulating other nerve fibres of the nerve trunk.

43. The method of claim 33, wherein the method is a primary method used in conjunction with another method to treat sleep disorders.

44. The method of claim 33, wherein the method is a secondary method used in conjunction with another method to treat sleep disorders.